RecruitingPhase IEN original

Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The purpose of this first in-human study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary clinical activity of M9140 in advanced solid tumors. This study contains 2 parts: Dose escalation (Part 1) and dose expansion (Part 2) Study details include: * Study Duration per participant: Approximately 4 months for Part 1 and 8 months for Part 2 * M9140 is not available through an expanded access program

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Osoby z rakiem jelita grubego (w zaawansowanym lub rozsianym stadium), które nie tolerują lub nie reagują na dotychczasowe leczenie.
  • Osoby w dobrym stanie ogólnym (zdolne do normalnej aktywności)
  • Osoby z odpowiednimi wynikami badań krwi, wątroby i nerek.

✗ Disqualifies

  • Osoby z innymi nowotworami w ciągu ostatnich 3 lat (z pewnymi wyjątkami, np. rak skóry).
  • Osoby z przerzutami do mózgu, które nie zostały wcześniej skutecznie wyleczone i nie są stabilne.
  • Osoby z aktywnymi chorobami zapalnymi jelit lub niedrożnością jelit.
  • Osoby z problemami kardiologicznymi (np. po zawale serca, z niewydolnością serca) w ciągu ostatnich 6 miesięcy.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 2, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (35)

California Cancer Associates for Research & Excellence, Inc.

Encinitas, United States

California Cancer Associates for Research & Excellence, Inc.

Fresno, United States

Rhode Island Hospital

Providence, United States

Mary Crowley Cancer Research

Dallas, United States

MD Anderson Cancer Center - Oncology

Houston, United States

NEXT Oncology

San Antonio, United States

The Ottawa Hospital Cancer Centre

Ottawa, Canada

University Health Network - Princess Margaret Cancer Centre

Toronto, Canada

National Cancer Center Hospital - Dept of Gastroenterology

Chūōku, Japan

National Cancer Center Hospital East

Kashiwa-shi, Japan

Saitama Cancer Center

Kitaadachi-gun, Japan

Cancer Institute Hospital of JFCR

Kōtoku, Japan

Aichi Cancer Center Hospital

Nagoya, Japan

Kindai University Hospital

Osakasayama-shi, Japan

Shizuoka Cancer Center

Sunto-gun, Japan

Kanagawa Cancer Center

Yokohama, Japan

Kyungpook National University Chilgok Hospital

Daegu, South Korea

National Cancer Center

Goyang-si, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Hospital Clinic de Barcelona

Barcelona, Spain

Hospital del Mar

Barcelona, Spain

Hospital HM Nou Delfos

Barcelona, Spain

Hospital Universitari Vall d'Hebron - VHIR

Barcelona, Spain

Hospital Universitario Reina Sofia

Córdoba, Spain

ICO l'Hospitalet - Hospital Duran i Reynals

L'Hospitalet de Llobregat, Spain

Centro Integral Oncologico Clara Campal

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario Fundacion Jimenez Diaz

Madrid, Spain

Hospital Universitario Quironsalud Madrid - NEXT Oncology

Madrid, Spain

Complejo Hospitalario Universitario de Santiago

Santiago de Compostela, Spain

Hospital Universitario Virgen del Rocio

Seville, Spain

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.