Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a first-in-human, Phase 1/2, open-label, dose escalation and dose expansion and combination study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Spevatamig (PT886). Patients with the following tumor types will be eligible for screening: unresectable or metastatic gastric adenocarcinoma, gastroesophageal junction (GEJ) adenocarcinoma, biliary tract carcinoma (BTC) and pancreatic ductal adenocarcinoma (PDAC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej i zdolność do wyrażenia świadomej zgody
- •Potwierdzony rozpoznaniem nowotworu (raka żołądka, połączenia przełyku i żołądka, dróg żółciowych lub trzustki)
- •Nowotwór zaawansowany lub z przerzutami, którego nie można operować
- •Wcześniej leczony na nowotwór zaawansowany lub leczenie nie przyniosło rezultatu
- •Możliwość pobrania próbki nowotworu do badań laboratoryjnych
- •Ogólny stan zdrowia pacjenta pozwalający na uczestnictwo w badaniu
- •Prawidłowe funkcjonowanie głównych narządów
✗ Disqualifies
- •Ciąża lub karmienie piersią
- •Kobiety w wieku rozrodczym nie stosujące skutecznej antykoncepcji
- •Aktywna choroba autoimmunologiczna wymagająca leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (11)
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, United States
USC Norris Comprehensive Cancer Center
Los Angeles, United States
Sarah Cannon Research Institute (SCRI)
Denver, United States
University of Iowa
Iowa City, United States
Norton Cancer Institute
Louisville, United States
Dana-Farber Cancer Institute (DFCI)
Boston, United States
Duke Cancer Center
Durham, United States
University of Pittsburgh Medical Center (UPMC)
Pittsburgh, United States
MD Anderson Cancer Center, GI Medical Oncology Dept
Houston, United States
NEXT Oncology
Fairfax, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Trial contact
Phanes Therapeutics
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/10/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.