A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation \[SC-CF\]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent musi mieć potwierdzonego raka płuca (niekomórkowego), który jest zaawansowany lub dał przerzuty i nie można go wyleczyć operacją lub chemioterapią z radioterapią.
- •Rak musi mieć specyficzną mutację: w grupach 1, 3, 3b, 5, 6, 7 mutację EGFR (tzw. delecję eksonu 19 lub mutację L858R w eksonie 21); w grupie 2 mutację EGFR Exon 20ins.
- •Pacjenci w grupach 1, 5, 6 nie mogli wcześniej przyjmować żadnych leków na zaawansowanego lub przerzutowego raka płuca.
- •Pacjenci w grupie 2 nie mogli wcześniej przyjmować żadnych leków na zaawansowanego lub przerzutowego raka płuca.
- •Pacjenci w grupach 3 i 3b musieli mieć progresję choroby po leczeniu lekiem osimertinib jako ostatnim terapii.
- •Pacjenci w grupie 4 muszą być obecnie leczeni lekiem amivantamab w zastrzyku co 2 tygodnie (w dawce 1050 mg lub 1400 mg w zależności od wagi) od co najmniej 8 tygodni, bez zmniejszenia dawki.
- •Pacjenci w grupie 7 musieli mieć progresję choroby po leczeniu skojarzonym lekami amivantamab i lazertinib jako ostatniej terapii.
✗ Disqualifies
- •Nie można włączyć pacjentów z rakiem płuca (niekomórkowym) o budowie płaskonabłonkowej do grup 2, 3, 3b i 7.
- •Mutacja EGFR musi zostać potwierdzona testem wykonanym w certyfikowanym laboratorium, badającym zarówno krew (krążące DNA nowotworowe), jak i tkankę guza.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (110)
University of California at San Diego
La Jolla, United States
University of California Irvine
Orange, United States
Stanford Cancer Institute
Stanford, United States
Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital
Washington D.C., United States
Baptist Lynn Cancer Institute
Boca Raton, United States
Mount Sinai Medical Center
Miami Beach, United States
AdventHealth
Orlando, United States
H. Lee Moffitt Cancer & Research Institute
Tampa, United States
University of Kansas Cancer Center
Westwood, United States
Sidney Kimmel Cancer Center - Bayview Campus
Baltimore, United States
Boston Medical Center
Boston, United States
Washington University School Of Medicine
St Louis, United States
Hackensack University Medical Center
Hackensack, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
Hematology-Oncology Associates of CNY
East Syracuse, United States
Novant Health 1
Charlotte, United States
Novant Health
Winston-Salem, United States
Cleveland Clinic 1
Cleveland, United States
Cleveland Clinic
Cleveland, United States
Cleveland Clinic 2
Mayfield Heights, United States
Cleveland Clinic 3
Warrensville Heights, United States
The Huntsman Cancer Institute
Salt Lake City, United States
Virginia Cancer Specialists
Fairfax, United States
Providence Regional Cancer Partnership
Everett, United States
Virginia Mason Medical Center
Seattle, United States
Swedish Cancer Institute
Seattle, United States
Fundacao Pio XII
Barretos, Brazil
PERSONAL Oncologia de Precisao e Personalizada
Belo Horizonte, Brazil
Instituto do Cancer de Londrina Hospital do Cancer de Londrina
Londrina, Brazil
Associacao Hospitalar Moinhos de Vento
Porto Alegre, Brazil
Instituto D Or de Pesquisa e Ensino IDOR
Rio de Janeiro, Brazil
Instituto D Or de Pesquisa e Ensino IDOR 1
Salvador, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, Brazil
Impar Servicos Hospitalares SA Hospital Nove de Julho
São Paulo, Brazil
Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, Brazil
Affiliated Hospital of Hebei University
Baoding, China
Jilin cancer hospital
Changchun, China
Sichuan Cancer Hospital
Chengdu, China
West China Hospital Sichuan University
Chengdu, China
The First Affiliated Hospital of PLA Army Medical University
Chongqing, China
The First Affiliated Hospital Sun Yat sen University
Guangzhou, China
The First Affiliated Hospital Zhejiang University College of Medicine
Hangzhou, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, China
Harbin medical university cancer hospital
Harbin, China
Huizhou Municipal Central Hospital
Huizhou, China
Liuzhou people's Hospital
Liuzhou, China
Fudan University Shanghai Cancer Center
Shanghai, China
Tianjin Medical University General Hospital
Tianjin, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
Hospital of Jiangnan University
Wuxi, China
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, China
Yantai Yuhuangding Hospital
Yantai, China
Centre Francois Baclesse
Caen, France
Centre Georges-François Leclerc
Dijon, France
Institut de Cancérologie du Gard
Nîmes, France
Institut Curie
Paris, France
Institut de cancerologie de l'ouest
Saint-Herblain, France
Gustave Roussy
Villejuif, France
Evangelische Lungenklinik Berlin
Berlin, Germany
Universitaetsklinikum Koeln
Cologne, Germany
LungenClinic Grosshansdorf GmbH
Grosshandorf, Germany
Lungenfachklinik Immenhausen
Immenhausen, Germany
Klinikum Würzburg Mitte gGmbH Standort Missioklinik
Würzburg, Germany
Rambam Medical Center
Haifa, Israel
Shaare Zedek Medical Center
Jerusalem, Israel
Meir Medical Center
Kfar Saba, Israel
Rabin Medical Center
Petah Tikva, Israel
Sheba Medical Center
Ramat Gan, Israel
Policlinico Hospital San Martino- IRCCS for Oncology
Genova, Italy
Ospedale San Raffaele
Milan, Italy
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
Azienda Ospedaliera San Gerardo
Monza, Italy
Azienda Ospedaliera Specialistica dei Colli
Naples, Italy
National Hospital Organization Himeji Medical Center
Himeji, Japan
Saiseikai Matsusaka Municipal Hospital
Matsusaka, Japan
Niigata Cancer Center Hospital
Niigata, Japan
Shizuoka Cancer Center
Shizuoka, Japan
The Cancer Institute Hospital of JFCR
Tokyo, Japan
Wakayama Medical University Hospital
Wakayama, Japan
University Malaya Medical Centre
Kuala Lumpur, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, Malaysia
Hospital Umum Sarawak
Kuching, Malaysia
Beacon Hospital Sdn Bhd
Petaling Jaya, Malaysia
National Cancer Center
Goyang-si, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Hosp Univ A Coruna
A Coruña, Spain
General University Hospital of Alicantet
Alicante, Spain
Hosp. Del Mar
Barcelona, Spain
Hosp. de La Santa Creu I Sant Pau
Barcelona, Spain
Hosp Univ Vall D Hebron
Barcelona, Spain
Inst. Cat. Doncologia-H Duran I Reynals
Barcelona, Spain
Hosp. Gral. Univ. Gregorio Maranon
Madrid, Spain
Hosp. Univ. Ramon Y Cajal
Madrid, Spain
Hosp. Univ. 12 de Octubre
Madrid, Spain
Hosp. Univ. La Paz
Madrid, Spain
Hosp Regional Univ de Malaga
Málaga, Spain
Hosp. Virgen Macarena
Seville, Spain
Hosp. Clinico Univ. de Valencia
Valencia, Spain
Hosp. Gral. Univ. Valencia
Valencia, Spain
Cheltenham General Hospital
Cheltenham, United Kingdom
Torbay Hospital-Devon
Devon, United Kingdom
Edinburgh Cancer Centre Western General
Edinburgh, United Kingdom
Leicester Royal Infirmary
Leicester, United Kingdom
University College London Hospitals
London, United Kingdom
Nottingham City Hospital
Nottingham, United Kingdom
Queen Alexandra Hospital
Portsmouth, United Kingdom
Trial contact
Study Contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
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