A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF altered (BRAF V600E or BRAF fusions) locally advanced or metastatic solid tumors, or recurrent or progressive primary central nervous system (CNS) tumors, including rare BRAF V600E-mutated solid tumors, including anaplastic thyroid, ovarian, cholangiocarcinoma or other rare cancers.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 8 lat, waga co najmniej 25 kg
- •Potwierdzony nowotwór litty lub guz mózgu pierwotny
- •Wykrycie mutacji lub fuzji genu BRAF w biopsji nowotworu lub we krwi
- •Dostępna próbka tkanki archiwalna do badań
- •Zgoda na badania obrazowe (tomografia) przed i podczas leczenia
- •Wcześniejsze leczenie standardowe lub nietolerancja dostępnych terapii
- •Ustąpienie lub zmniejszenie efektów ubocznych z poprzednich terapii
Simplified criteria — AI translation
Trial details
- Minimum age
- 8 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (70)
Precision NextGen Oncology & Research Center
Beverly Hills, United States
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, United States
University of California Los Angeles Rheumatology
Westwood, Los Angeles, United States
Norwalk Hospital
Norwalk, United States
University of Miami Hospital and Clinics
Miami, United States
The John Hopkins Hospital
Baltimore, United States
Maryland Oncology Hematology- Columbia
Rockville, United States
Tufts Medical Center
Boston, United States
Massachusetts General Hospital
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
St. Luke's Hospital
Duluth, United States
Mosaic Life Care at Saint Joseph - Medical Center
Saint Joseph, United States
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy
Omaha, United States
Overlook Medical Center
Summit, United States
Columbia University Irving Medical Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Atrium Health Wake Forest Baptist - Comprehensive Cancer Center
Winston-Salem, United States
Nationwide Children's Hospital
Colombus, United States
The Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute
Columbus, United States
Taylor Cancer Research Center
Maumee, United States
Toledo Clinic Cancer Center
Toledo, United States
Thomas Jefferson University
Philadelphia, United States
Lifespan Cancer Institute - Rhode Island Hospital
Providence, United States
SCRI - TriStar Medical Group Children's Specialists
Nashville, United States
SCRI Oncology Partners
Nashville, United States
Baylor Scott & White Research Institute
Dallas, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Baylor Scott & White Medical Center
Temple, United States
University of Washington School of Medicine
Seattle, United States
West Virginia University Health Sciences Campus
Morgantown, United States
Newcastle Private Hospital
New Lambton Heights, Australia
Orange Health Service
Orange, Australia
Sydney Children's Hospital Network - Randwick
Randwick, Australia
Flinders Medical Centre
Bedford Park, Australia
The Alfred
Melbourne, Australia
Sunny brook Health Sciences Centre- Bayview Campus
Toronto, Canada
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Canada
Institut Bergonie
Bordeaux, France
Hôpital Nord de Marseille
Marseille, France
Hôpital Morvan
Brest, France
Institut de Cancerologie de l'Ouest- Angers
Angers, France
Gustave Roussy
Villejuif, France
Institut Universitaire du Cancer de Toulouse Oncopole
Toulouse, France
Hôpital Universitaire Pitié Salpêtrière
Paris, France
Universitätsklinikum Heidelberg
Heidelberg, Germany
Krankenhaus Nordwest
Frankfurt am Main, Germany
Charité - Universitätsmedizin Berlin
Berlin, Germany
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
Meldola, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Naples, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
Milan, Italy
Istituto Europeo di Oncologia
Milan, Italy
Erasmus Medisch Centrum
Rotterdam, Netherlands
Haukeland Univeritetssjukehus
Bergen, Norway
Oslo Universitetssykehus-Radiumhospitalet
Oslo, Norway
Catholic University of Korea Saint Vincent's Hospital
Suwon, South Korea
Seoul National University Hospital
Suwon, South Korea
Dong-A University Hospital
Pusan, South Korea
Chonnam National University Hwasun Hospital
Hwasun, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea
Hospital Clinico Universitarlo de Santiago
Santiago de Compostela, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Infantil Universitario Niño Jesús
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen del Rocío
Seville, Spain
Hospital Clinico Universitarlo de Valencia
Valencia, Spain
Skånes Universitetssjukhus
Lund, Sweden
Karolinska Universitetssjukhuset
Solna, Sweden
The Christie NHS Foundation Trust
Manchester, United Kingdom
Sarah Cannon Research Institute
London, United Kingdom
Trial contact
Jessica Rine
Geri Bardelli
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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