A Phase I Intravesical PPM Therapy for NMIBC
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This clinical trial is to determine the safety and effectiveness of an investigational bladder cancer drug named "PLZ4-coated paclitaxel-loaded nanoscale micelle (PPM)." PPM is tiny particles that contain the chemotherapy drug paclitaxel. PLZ4 is a molecule that can possibly guide PPM to specifically target and deliver paclitaxel into and kill bladder cancer cells. In this trial, PPM will be instilled into the bladder cavity to treat bladder cancer that does not invade into the muscle layer of the bladder and that has failed the treatment of another drug Bacillus Calmette-Guérin (BCG). Up to 29 patients will be enrolled into the trial. The main goal of this trial is to determine the dose of PPM for future clinical trials, assess the toxicity and obtain preliminary data regarding its effectiveness.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie rak pęcherza moczowego, który nie wnika w głębokie warstwy pęcherza
- •Biopsja wykonana w ciągu 3 miesięcy przed włączeniem do badania
- •Rak oporny na leczenie BCG lub brak tolerancji na to leczenie
- •Pacjent odmawia operacji usunięcia pęcherza lub jej nie toleruje
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu
- •Spodziewana długość życia ponad 24 miesiące
- •Brak równoczesnego leczenia chemią, radioterapią lub immunoterapią
- •Wyzdrowiał z objawów ubocznych poprzedniego leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, United States
Trial contact
Chong-Xian Pan, MD PhD
Lori Lerner, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.
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