Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is a prospective, open-label, randomized phase 3 clinical trial. It aims to investigate if the early introduction of intensified chemotherapy (3 months of modified FOLFIRINOX) improves the 3-year disease-free survival rate compared to standard treatment (FOLFOX/CAPOX for an additional three months to complete six months of standard adjuvant chemotherapy) in patients with stage 2-3 colon cancer in whom ctDNA MRD in the part 1 study remained positive during adjuvant FOLFOX/CAPOX chemotherapy
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci, którzy świadomie zgodzili się na udział w badaniu i podpisali formularz zgody.
- •Wiek od 19 do 75 lat.
- •Potwierdzony rak jelita grubego.
- •Rak jelita grubego w stadium II-III (wysokie ryzyko nawrotu dla stadium II).
- •Pacjenci, którzy zakończyli standardowe leczenie pooperacyjne (chemioterapię FOLFOX lub CAPOX).
- •Badanie wykazało obecność śladów DNA nowotworowego we krwi po operacji.
- •Ogólny stan zdrowia pozwala na uczestnictwo w badaniu (skala sprawności ECOG 0-1).
✗ Disqualifies
- •Kobiety w ciąży lub karmiące piersią.
- •Aktywne infekcje wirusowe, takie jak HIV.
- •Poważne problemy z sercem, które nie są stabilne.
- •Kobiety i mężczyźni w wieku rozrodczym, którzy nie chcą stosować antykoncepcji.
Simplified criteria — AI translation
Trial details
- Minimum age
- 19 Years
- Maximum age
- 75 Years
- Last updated (source)
- August 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (13)
Dong-A University Hospital
Busan, South Korea
Kyungpook National University Chilgok Hospital
Daegu, South Korea
National Cancer Center
Goyang, South Korea
Chonnam National University Hwasun Hospital
Hwasun, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Asan Medical Center
Seoul, South Korea
Chung-Ang University Hospital
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea
SMG-SNU Boramae Medical Center
Seoul, South Korea
Ajou University Hospital
Suwon, South Korea
Trial contact
Sae-Won Han, MD,PhD
Jinwon Kim, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/1/2026.
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