A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Esophageal cancer, which has a low 5-year overall survival rate (\<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a significant number of esophageal cancers. Itraconazole, a widely used anti-fungal medication, effectively inhibits these pathways. In this multi-site phase II trial, the investigators will evaluate the effect of itraconazole as a neoadjuvant therapy added to standard of care chemoradiation or chemoimmunotherapy and surgery in the the treatment of locoregional esophageal and gastroesophageal junction cancers.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zdolność do wyrażenia świadomej zgody na udział w badaniu
- •Potwierdzony rozpoznanie raka przełyku lub raka połączenia przełyku ze żołądkiem, który można operacyjnie usunąć
- •Dobra ogólna kondycja fizyczna (ocena 0-2 w skali WHO)
- •Prawidłowa funkcja nerek i wątroby
✗ Disqualifies
- •Niewydolność serca w zaawansowanym stadium (klasa III-IV)
- •Poważnie nieprawidłowe wyniki badań wątroby
- •Uczulenie na itrakonazol
- •Dodatni test ciążowy
- •Zaburzenia rytmu serca (wydłużony QTc)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, United States
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, United States
Durham VA Medical Center, Durham, NC
Durham, United States
VA Portland Health Care System, Portland, OR
Portland, United States
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
Dallas, United States
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, United States
Trial contact
David H Wang, MD PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/10/2026.
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