A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to learn about how an investigational drug intervention completed before doing prostate surgery (specifically, radical prostatectomy with lymph node dissection) may help in treatment of high risk localized prostate cancers that are most resistant to standard treatments. This is a phase II research study. For this study, capivasertib, the study drug, will be taken with intensified androgen deprivation drugs (iADT; abiraterone and leuprolide) prior to radical prostatectomy. This study drug treatment will be evaluated to see if it is effective in shrinking and destroying prostate cancer tumors prior to surgery and to further evaluate its safety prior to prostate cancer surgery.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Podpisana zgoda na uczestnictwo w badaniu
- •Rak gruczołu krokowego potwierdzony badaniem mikroskopowym, bez przerzutów na odległe
- •Wysokie ryzyko raka prostaty: wysoki stopień złośliwości Gleasona (>7), zaawansowana faza lokalnie (T3) lub wysoki poziom PSA (>20)
- •Brak śladów raka w kościach lub węzłach chłonnych
- •Planowana operacyjna usunięcie prostaty jako główne leczenie
- •Pacjent wybrał operację po rozmowie o innych opcjach (radioterapia)
- •Gotowość do pobrania próbki tkanki do badań
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 25, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (9)
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, United States
Jesse Brown VA Medical Center, Chicago, IL
Chicago, United States
St. Louis VA Medical Center John Cochran Division, St. Louis, MO
St Louis, United States
James J. Peters VA Medical Center, Bronx, NY
The Bronx, United States
VA Portland Health Care System, Portland, OR
Portland, United States
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, United States
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, United States
South Texas Health Care System, San Antonio, TX
San Antonio, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, United States
Trial contact
Ryan P Kopp, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/26/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.