Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests whether mosunetuzumab and/or polatuzumab vedotin helps benefit patients who have received chemotherapy (fludarabine and cyclophosphamide) followed by chimeric antigen receptor (CAR) T-cell therapy (tisagenlecleucel, axicabtagene ciloleucel, or lisocabtagene maraleucel) for diffuse large B-cell lymphoma that has come back (recurrent) or that does not respond to treatment (refractory) or grade IIIb follicular lymphoma. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Polatuzumab vedotin is a monoclonal antibody, called polatuzumab, linked to a drug called vedotin. Polatuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, and delivers vedotin to kill them. Chemotherapy drugs, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. CAR T-cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient's blood. Then the gene for a special receptor that binds to a certain protein on the patient's cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor. Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers. Giving mosunetuzumab and/or polatuzumab vedotin after chemotherapy and CAR T-cell therapy may be more effective at controlling or shrinking the cancer than not giving them.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rozpoznanie chłoniaka B-oponowego, chłoniaka pęcherzykowego stopnia 3b lub pierwotnego chłoniaka śródpiersia
- •Widoczne zmiany nowotworu o wymiarze ponad 1,5 cm do zmierzenia
- •Pacjent kwalifikuje się do standardowej terapii CAR T-cell zatwierdzonej przez FDA
- •Podpisana zgoda na pobór komórek T do terapii CAR T-cell
- •Jeśli chłoniak rozszerzył się na mózg, musi być bez objawów z tej lokalizacji
✗ Disqualifies
- •Wcześniejsze stosowanie polatuzumab vedotin lub mosunetuzumab w terapii pośredniej (miedzy poborem komórek a rozpoczęciem leczenia)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (95)
Banner University Medical Center - Tucson
Tucson, United States
University of Arizona Cancer Center-North Campus
Tucson, United States
Highlands Oncology Group - Fayetteville
Fayetteville, United States
University of Arkansas for Medical Sciences
Little Rock, United States
Highlands Oncology Group - Rogers
Rogers, United States
Highlands Oncology Group
Springdale, United States
UC Irvine Health Cancer Center-Newport
Costa Mesa, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UCI Health Laguna Hills
Laguna Hills, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
UCSF Medical Center-Parnassus
San Francisco, United States
UF Health Cancer Institute - Gainesville
Gainesville, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Saint Luke's Cancer Institute - Boise
Boise, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, United States
Saint Luke's Cancer Institute - Meridian
Meridian, United States
Saint Luke's Cancer Institute - Nampa
Nampa, United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, United States
University of Illinois
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Loyola University Medical Center
Maywood, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
LSU Health Baton Rouge-North Clinic
Baton Rouge, United States
Our Lady of the Lake Physician Group
Baton Rouge, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, United States
Bronson Battle Creek
Battle Creek, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, United States
Henry Ford Medical Center-Fairlane
Dearborn, United States
Wayne State University/Karmanos Cancer Institute
Detroit, United States
Henry Ford Hospital
Detroit, United States
Weisberg Cancer Treatment Center
Farmington Hills, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
Trinity Health Grand Rapids Hospital
Grand Rapids, United States
Allegiance Health
Jackson, United States
Bronson Methodist Hospital
Kalamazoo, United States
West Michigan Cancer Center
Kalamazoo, United States
Beacon Kalamazoo Cancer Center
Kalamazoo, United States
Trinity Health Muskegon Hospital
Muskegon, United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, United States
Henry Ford Medical Center-Columbus
Novi, United States
Corewell Health Reed City Hospital
Reed City, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, United States
Henry Ford Health Providence Southfield Hospital
Southfield, United States
Munson Medical Center
Traverse City, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Henry Ford Wyandotte Hospital
Wyandotte, United States
University of Michigan Health - West
Wyoming, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
University of New Mexico Cancer Center
Albuquerque, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
NYP/Weill Cornell Medical Center
New York, United States
University of Rochester
Rochester, United States
Wilmot Cancer Institute at Webster
Webster, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
Atrium Health Cabarrus/LCI-Concord
Concord, United States
Duke University Medical Center
Durham, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Case Western Reserve University
Cleveland, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Providence Newberg Medical Center
Newberg, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Oregon Health and Science University
Portland, United States
Geisinger Medical Center
Danville, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, United States
Medical University of South Carolina
Charleston, United States
Prisma Health Cancer Institute - Easley
Easley, United States
Prisma Health Cancer Institute - Butternut
Greenville, United States
Prisma Health Cancer Institute - Faris
Greenville, United States
Prisma Health Cancer Institute - Eastside
Greenville, United States
Prisma Health Cancer Institute - Greer
Greer, United States
Prisma Health Cancer Institute - Seneca
Seneca, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
University of Vermont Medical Center
Burlington, United States
University of Vermont and State Agricultural College
Burlington, United States
Dartmouth Cancer Center - North
Saint Johnsbury, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Medical Center-First Hill
Seattle, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Medical College of Wisconsin
Milwaukee, United States
Froedtert and MCW Moorland Reserve Health Center
New Berlin, United States
Trial contact
Erin Rogers
Dana Sparks
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/16/2026.
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