MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
In this first-in human, phase I/IIa study, the safety and efficacy of \[212Pb\]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with nivolumab in subjects with unresectable and metastatic melanoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Diagnoza zaawansowanego czerniaaka, który nie poddaje się operacji chirurgicznej (stadium III lub IV) z przerzutami
- •Wcześniejszy brak skuteczności co najmniej jednego standardowego leczenia dla czerniaaka zaawansowanego
- •Potwierdzenie obecności celu dla nowego leku (MC1R) w guzach za pomocą badania obrazowego (PET lub SPECT)
- •Obecność mierzalnych guzów potwierdzonych badaniem obrazowym w ciągu ostatnich 45 dni
- •Zdolność do leżenia nieruchomo przez do 2 godzin podczas badań obrazowych
- •Dla kobiet w wieku rozrodczym: zgoda na stosowanie skutecznej antykoncepcji przez 6 miesięcy po zakończeniu leczenia
- •Dla mężczyzn w wieku rozrodczym: zgoda na stosowanie prezerwatyw przez 6 miesięcy po zakończeniu leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 90 Years
- Last updated (source)
- October 13, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (16)
University of California Irvine
Orange, United States
Mayo Clinic
Jacksonville, United States
University of Miami
Miami, United States
Sarasota Memorial Hospital
Sarasota, United States
University of Iowa
Iowa City, United States
University of Kentucky
Lexington, United States
M Health Fairview University of Minnesota Medical Center
Minneapolis, United States
Mayo Clinic Rochester
Rochester, United States
Saint Louis University Hospital
St Louis, United States
Washington University of St. Louis
St Louis, United States
Nebraska Cancer Specialists
Omaha, United States
UNC Hospitals, The University of North Carolina at Chapel Hill
Chapel Hill, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
Fox Chase Cancer Center
Philadelphia, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
University of Wisconsin Carbone Cancer Center
Madison, United States
Trial contact
ClinicalTrials at Perspectivetherapeutics
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/14/2026.
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