Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares total ablative therapy and usual systemic therapy to usual systemic therapy alone in treating patients with colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (IV) (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. Ablative means that the intention of the local treatment is to eliminate the cancer at that metastatic site. The ablative local therapy will consist of very focused, intensive radiotherapy called stereotactic ablative radiotherapy (SABR) with or without surgical resection and/or microwave ablation, which is a procedure where a needle is temporarily inserted in the tumor and heat is used to destroy the cancer cells. SABR, surgical resection, and microwave ablation have been tested for safety, but it is not scientifically proven that the addition of these treatments are beneficial for your stage of cancer. The addition of ablative local therapy to all known metastatic sites to the usual approach of systemic therapy could shrink or remove the tumor(s) or prevent the tumor(s) from returning.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak jelita grubego z potwierdzonymi przerzutami.
- •Brak stwierdzonych pewnych cech genetycznych guza (MSI, BRAF V600E).
- •Możliwe leczenie glejaków w mózgu, jeśli nie postępują.
- •Guz pierwotny jest już usunięty lub można go usunąć chirurgicznie.
- •Maksymalnie 4 miejsca z przerzutami widoczne na badaniach obrazowych.
- •Przerzuty muszą być widoczne na obrazach, nie trzeba potwierdzać ich pobraniem tkanki.
- •Jeśli są przerzuty do wątroby, muszą być też przerzuty w innym miejscu ciała.
- •Przerzuty muszą nadawać się do leczenia chirurgicznego, mikrofalami lub zaawansowaną radioterapią (SABR).
✗ Disqualifies
- •Są przerzuty do otrzewnej lub sieci, jeśli badania wskazują na ich obecność, a nie potwierdzono ich braku podczas operacji.
- •Guz pierwotny jest nieoperacyjny.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (186)
Kingman Regional Medical Center
Kingman, United States
Mayo Clinic Hospital in Arizona
Phoenix, United States
Tower Cancer Research Foundation
Beverly Hills, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
Cedars-Sinai Medical Center
Los Angeles, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
Beebe Medical Center
Lewes, United States
Beebe South Coastal Health Campus
Millville, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
Christiana Care Health System-Christiana Hospital
Newark, United States
Beebe Health Campus
Rehoboth Beach, United States
Christiana Care Health System-Wilmington Hospital
Wilmington, United States
Sibley Memorial Hospital
Washington D.C., United States
George Washington University Medical Center
Washington D.C., United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
UM Sylvester Comprehensive Cancer Center at Doral
Doral, United States
UF Health Cancer Institute - Gainesville
Gainesville, United States
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, United States
Jupiter Medical Center
Jupiter, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
Miami Cancer Institute
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
Grady Health System
Atlanta, United States
Emory Proton Therapy Center
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Saint Luke's Cancer Institute - Boise
Boise, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, United States
Saint Luke's Cancer Institute - Meridian
Meridian, United States
Saint Luke's Cancer Institute - Nampa
Nampa, United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, United States
University of Illinois
Chicago, United States
Baptist Health Floyd
New Albany, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, United States
Mercy Cancer Center-West Lakes
Clive, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Greater Regional Medical Center
Creston, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
Mercy Medical Center-West Lakes
West Des Moines, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
Baptist Health Louisville
Louisville, United States
University Medical Center New Orleans
New Orleans, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, United States
Boston Medical Center
Boston, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health Medical Center - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health Medical Center - Canton
Canton, United States
Chelsea Hospital
Chelsea, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, United States
Corewell Health Dearborn Hospital
Dearborn, United States
Henry Ford Hospital
Detroit, United States
Corewell Health Farmington Hills Hospital
Farmington Hills, United States
Genesys Hurley Cancer Institute
Flint, United States
Hurley Medical Center
Flint, United States
Allegiance Health
Jackson, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Henry Ford Health Providence Novi Hospital
Novi, United States
Corewell Health William Beaumont University Hospital
Royal Oak, United States
Henry Ford Health Providence Southfield Hospital
Southfield, United States
Corewell Health Beaumont Troy Hospital
Troy, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Regions Hospital
Saint Paul, United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, United States
Baptist Cancer Center-Grenada
Grenada, United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, United States
Parkland Health Center - Farmington
Farmington, United States
Heartland Regional Medical Center
Saint Joseph, United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, United States
Mercy Hospital Springfield
Springfield, United States
Mercy Hospital South
St Louis, United States
Missouri Baptist Medical Center
St Louis, United States
Mercy Hospital Saint Louis
St Louis, United States
Missouri Baptist Sullivan Hospital
Sullivan, United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, United States
Billings Clinic Cancer Center
Billings, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Nebraska Medicine-Bellevue
Bellevue, United States
Nebraska Medicine-Village Pointe
Omaha, United States
University of Nebraska Medical Center
Omaha, United States
Renown Regional Medical Center
Reno, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Englewood Hospital and Medical Center
Englewood, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
University of New Mexico Cancer Center
Albuquerque, United States
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, United States
Memorial Sloan Kettering Commack
Commack, United States
The New York Hospital Medical Center of Queens
Flushing, United States
Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills, United States
Northwell Health Cancer Institute at Huntington
Greenlawn, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
Northern Westchester Hospital
Mount Kisco, United States
Mount Sinai West
New York, United States
Mount Sinai Hospital
New York, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Manhattan Eye Ear and Throat Hospital
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
NYP/Weill Cornell Medical Center
New York, United States
Lenox Hill Hospital
New York, United States
Queens Cancer Center
Rego Park, United States
University of Rochester
Rochester, United States
Phelps Memorial Hospital Center
Sleepy Hollow, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Westchester Medical Center
Valhalla, United States
Wilmot Cancer Institute at Webster
Webster, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
Atrium Health Cabarrus/LCI-Concord
Concord, United States
East Carolina University
Greenville, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Sanford Bismarck Medical Center
Bismarck, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Dayton Physicians LLC-Miami Valley South
Centerville, United States
Miami Valley Hospital South
Centerville, United States
MetroHealth Medical Center
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Miami Valley Hospital
Dayton, United States
Premier Blood and Cancer Center
Dayton, United States
Dayton Physician LLC - Englewood
Dayton, United States
Miami Valley Hospital North
Dayton, United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, United States
Dayton Physicians LLC-Atrium
Franklin, United States
Miami Valley Cancer Care and Infusion
Greenville, United States
Upper Valley Medical Center
Troy, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Oregon Health and Science University
Portland, United States
Christiana Care Health System-Concord Health Center
Chadds Ford, United States
Geisinger Medical Center
Danville, United States
Penn State Milton S Hershey Medical Center
Hershey, United States
Lancaster General Ann B Barshinger Cancer Institute
Lancaster, United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, United States
Allegheny General Hospital
Pittsburgh, United States
West Penn Hospital
Pittsburgh, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
University of Texas Health Science Center at San Antonio
San Antonio, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
Bon Secours Memorial Regional Medical Center
Mechanicsville, United States
Bon Secours Saint Francis Medical Center
Midlothian, United States
Bon Secours Saint Mary's Hospital
Richmond, United States
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, United States
Valley Medical Center
Renton, United States
Edwards Comprehensive Cancer Center
Huntington, United States
Aspirus Cancer Care-Antigo-Volm Cancer Center
Antigo, United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
Appleton, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
Brookfield, United States
Ascension Calumet Hospital-Chilton
Chilton, United States
Ascension Southeast Wisconsin Hospital - Franklin
Franklin, United States
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
Mequon, United States
Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
Milwaukee, United States
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
Milwaukee, United States
Medical College of Wisconsin
Milwaukee, United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
Oshkosh, United States
Ascension All Saints Hospital-Spring Street-Racine
Racine, United States
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
Rhinelander, United States
Aspirus Cancer Care - Stevens Point
Stevens Point, United States
Aspirus Cancer Care-Wausau
Wausau, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
Wauwatosa, United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, United States
Arthur J E Child Comprehensive Cancer Centre
Calgary, Canada
Trial contact
Eric D. Miller, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.