Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I/II trial studies the side effects and best dose of temozolomide and M1774 and how well they works in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) and may have spread to nearby tissue, lymph nodes, or distant parts of the body (advanced). Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill tumor cells and slow down or stop tumor growth. M1774 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Adding M1774 to temozolomide may shrink or stabilize cancer for longer than temozolomide alone.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnoza zaawansowanego raka, który rozprzestrzenił się na inne części ciała
- •Brak wcześniejszego leczenia temozolomidem lub lekami hamującymi ATR
- •Wcześniejsze leczenie nie przyniosło poprawy lub pacjent nie toleruje standardowych leków
- •W fazie drugiej badania: rak jelita grubego ze zmianami genetycznymi MGMT w archiwalnych próbkach tkanek
✗ Disqualifies
- •Wcześniejsza ciężka alergiczna reakcja na jeden z leków chemicznych stosowanych w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (23)
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UC San Diego Moores Cancer Center
La Jolla, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Yale University
New Haven, United States
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, United States
Memorial Hospital East
Shiloh, United States
University of Kansas Clinical Research Center
Fairway, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
National Cancer Institute Developmental Therapeutics Clinic
Bethesda, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Trial contact
Site Public Contact
Farshid Dayyani
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael Cecchini
PRINCIPAL_INVESTIGATOR
Site Public Contact
Raed Al-Rajabi
PRINCIPAL_INVESTIGATOR
Site Public Contact
A P. Chen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Abdul Rafeh Naqash
PRINCIPAL_INVESTIGATOR
Site Public Contact
Janie Y. Zhang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Elizabeth J. Davis
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/17/2026.
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