Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Background: Bruton s tyrosine kinase inhibitors (BTKi) are used to treat a form of leukemia. But taking BTKi can also increase a person s risk of developing an abnormal heart rhythm. This can cause sudden death. In this natural history study, researchers want to learn how BTKi affects the heart. Objective: To identify and monitor the effects of BTKi on the heart. Eligibility: People aged 18 and older currently receiving or planning to receive BTKi or venetoclax. Design: Participants who have not yet started BTKi will have 2 required clinic visits: 1 before they start taking BTKi, and 1 about 6 months later. Participants who are already taking BTKi will have 1 required visit. Participants will undergo multiple tests: A physical exam, including collection of blood and saliva. A test that measures heart activity via stickers placed on the chest. A test that uses sound waves to capture images of the heart. An exercise stress test that monitors heart activity and blood pressure while the participant works on a treadmill or stationary bike. Sound wave images of the heart may also be taken while the participant exercises. Stress magnetic resonance imaging (MRI) may be done in place of an exercise test. Participants will lie on a table that slides into a tube. They will be given drugs to stress the heart while images are taken. Participants may wear a device to monitor their heart at home. Participants may have repeat visits if they develop heart symptoms or if they need to stop taking BTKi. They will have follow-up phone calls each year for up to 3 years.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Masz 18 lat lub więcej.
- •Obecnie leczysz się lub planujesz zacząć leczenie lekami BTKi lub Wenetoklaks.
- •Zgadzasz się wziąć udział we wszystkich zaplanowanych wizytach i badaniach.
- •Rozumiesz zasady badania i zgadzasz się na podpisanie formularza zgody.
✗ Disqualifies
- •Miałeś poważne problemy z sercem (zawał, niewydolność serca) w ciągu ostatnich 3 miesięcy.
- •Jesteś w ciąży lub karmisz piersią (leki BTKi są przeciwwskazane w tych przypadkach).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 110 Years
- Last updated (source)
- July 17, 2026
- Sex
- No restrictions
Locations (1)
National Institutes of Health Clinical Center
Bethesda, United States
Trial contact
Ingrid C Frey
Christine E Gruessner, M.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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