A Pilot Study of Monitoring Insulin Levels and Treating Hyperinsulinemia and Hyperglycemia With Pioglitazone in Patients Treated With Alpelisib for Metastatic Breast Cancer.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this study is to test whether monitoring insulin levels and using pioglitazone to treat hyperglycemia and hyperinsulinemia in patients treated with Alpelisib for metastatic breast cancer is feasible and safe, and to assess the rates of glycemic control, dose reductions and treatment discontinuation and the progression free survival of patients treated with this regimen.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak piersi z przerzutami, dodatni na receptor estrogenowy, ujemny na HER2, z mutacją PIK3CA, przygotowany do leczenia Alpelisibem i fulwestrantem
- •Wiek 18-85 lat
- •Ogólny stan zdrowia pozwalający na codzienne aktywności (stopień 0-2)
- •Zdolność do zrozumienia informacji i chęć podpisania zgody na udział w badaniu
✗ Disqualifies
- •Zaburzenia lub choroby przewodu pokarmowego mogące wpłynąć na wchłanianie leku
- •Niekontrolowana cukrzyca (HbA1c powyżej 8%)
- •Cukrzyca leczona insuliną
- •Inne niekontrolowane choroby, w tym aktywne infekcje, problemy sercowe lub poważne problemy psychiczne
- •Ciąża
- •Uczulenie na pioglitazon
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 85 Years
- Last updated (source)
- March 3, 2023
- Sex
- Female only
Therapies / drugs in trial
Locations (1)
Rambam Health Care Campus
Haifa, Israel
Trial contact
Ayelet Shai, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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