A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and activity of single-agent divarasib or combined with other anti-cancer therapies in participants with previously untreated, advanced or metastatic non-small cell lung cancer (NSCLC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzenie obecności mutacji KRAS G12C
- •Próbka tkanki guza z raportem patologicznym
- •Dobry ogólny stan zdrowia (ECOG 0-1)
- •Zaawansowany lub przerzutowy rak płuca, który nie kwalifikuje się do operacji
- •Brak wcześniejszego leczenia systemowego zaawansowanego raka płuca
- •Możliwość zmierzenia wielkości guza
- •Pacjenci z przerzutami mózgu bez objawów (wybrana grupa)
✗ Disqualifies
- •Obecność innego wariantu genetycznego nowotworu z dostępnym lekiem
- •Rak płuca typu niedrobiazgowy
- •Przerzuty do mózgu z objawami lub wymagające natychmiastowego leczenia
- •Wcześniejsze leczenie inhibitorami KRAS G12C
- •Alergja na składniki leku divarasib lub powiązane leki
- •Idiopatyczne włóknienie płuc lub inne choroby płuc
- •Inne nowotwory w ciągu ostatnich 5 lat
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 13, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (71)
City of Hope National Medical Center
Duarte, United States
City of Hope - Seacliff
Huntington Beach, United States
City of Hope at Irvine Lennar
Irvine, United States
UCSD Moores Cancer Center
La Jolla, United States
City of Hope - Long Beach Elm
Long Beach, United States
Yale Cancer Center
New Haven, United States
Florida Cancer Specialists - SOUTH - SCRI - PPDS
Fort Myers, United States
Florida Cancer Specialists - NORTH - SCRI - PPDS
St. Petersburg, United States
Florida Cancer Specialists - EAST - SCRI - PPDS
West Palm Beach, United States
NYU Langone Hospital - Long Island
Mineola, United States
NYU Cancer Center
New York, United States
Mount SInai Medical Center
New York, United States
Montefiore Medical Center - Montefiore Medical Park
The Bronx, United States
MD Anderson Cancer Center
Houston, United States
Oncology & Hematology Associates of Southwest Virginia, Inc
Blacksburg, United States
Virginia Oncology Associates
Norfolk, United States
Hospital Britanico
Buenos Aires, Argentina
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, Argentina
Centro Oncologico Riojano Integral (CORI)
La Rioja, Argentina
Concord Repatriation General Hospital
Concord, Australia
Peter MacCallum Cancer Centre
Melbourne, Australia
Alfred Health
Melbourne, Australia
Cliniques Universitaires St-Luc
Brussels, Belgium
Jessa Zkh (Campus Virga Jesse)
Hasselt, Belgium
Clinique Ste-Elisabeth
Namur, Belgium
AZ Delta (Campus Rumbeke)
Roeselare, Belgium
Hospital de Cancer de Barretos
Barretos, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, Brazil
Ottawa Hospital Regional Cancer Centre
Ottawa, Canada
Princess Margaret Cancer Center
Toronto, Canada
Jewish General Hospital
Montreal, Canada
Hunan Cancer Hospital
Changsha, China
Harbin Medical University Cancer Hospital
Harbin, China
Shanghai Pulmonary Hospital
Shanghai, China
Rambam Medical Center
Haifa, Israel
Rabin MC
Petah Tikva, Israel
Tel Aviv Sourasky Medical Ctr
Tel Aviv, Israel
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Italy
Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
Irccs Istituto Nazionale Dei Tumori (Int)
Milan, Italy
A.O. Universitaria S. Luigi Gonzaga
Orbassano, Italy
National Cancer Center Hospital East
Chiba, Japan
Kindai University Hospital
Osaka, Japan
National Cancer Center Hospital
Tokyo, Japan
The Cancer Institute Hospital of JFCR
Tokyo, Japan
Wakayama Medical University Hospital
Wakayama, Japan
NKI The Netherlands Cancer Institute
Amsterdam, Netherlands
UMC St Radboud
Nijmegen, Netherlands
Uniwersyteckie Centrum Kliniczne
Gda?sk, Poland
Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II
Krakow, Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, Poland
Pusan National University Hospital
Busan, South Korea
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
ICO Badalona-H.U. Germans Trias i Pujol
Badalona, Spain
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Virgen del Rocio
Seville, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
Sahlgrenska University Hospital
Gothenburg, Sweden
Universitätsspital Basel
Basel, Switzerland
Inselspital Bern
Bern, Switzerland
Taichung Veterans General Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan Uni Hospital
Taipei, Taiwan
Chang Gung Medical Foundation - Linkou
Taoyuan, Taiwan
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
Barts & London School of Med
London, United Kingdom
Trial contact
Reference Study ID Number: BO44426 https://forpatients.roche.com/ No attachments to email below.
Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.
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