A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek pacjenta od 1 miesiąca do 21 lat
- •Potwierdzony rozpoznaniem białaczki JMML według międzynarodowych standardów
- •Prawidłowa praca nerek (oczyszczanie kreatyniny co najmniej 70 ml/min/1.73m2 lub prawidłowy poziom kreatyniny)
- •Wystarczająca ogólna kondycja zdrowotna do tolerowania leczenia (wynik Karnofsky'ego lub Lansky'ego powyżej 50%)
- •Mutacja genetyczna charakterystyczna dla JMML (w genach PTPN11, KRAS, NRAS, RRAS, RRAS2, NF1 lub CBL)
✗ Disqualifies
- •Wcześniejsze leczenie białaczki (z wyjątkiem przedoperacyjnego zmniejszenia komórek białaczki hydroksyureą lub 6-merkaptopu ryną)
- •Przeszczep szpiku kostnego wykonany wcześniej
- •Zaburzenia czynności nerek poniżej wymaganego progu
Simplified criteria — AI translation
Trial details
- Minimum age
- 1 Month
- Maximum age
- 21 Years
- Last updated (source)
- September 4, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (21)
Phoenix Children's Hospital
Phoenix, United States
Children's Hospital Los Angeles
Los Angeles, United States
University of California San Francisco
San Francisco, United States
Children's Hospital of Colorado
Denver, United States
Children's National Medical Center
Washington D.C., United States
University of Miami
Miami, United States
Children's Hospital of Atlanta
Atlanta, United States
Lurie Children's Hospital of Chicago
Chicago, United States
Indiana University/Riley Hospital for Children
Indianapolis, United States
Sidney Kimmel Cancer Center at Johns Hopkins
Baltimore, United States
C.S. Mott Children's Hospital
Ann Arbor, United States
Children's Mercy Hospital
Kansas City, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Levine Children's Hospital at Carolinas
Charlotte, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
Oregon Health & Science University
Portland, United States
Children's Hospital of Philadelphia
Philadelphia, United States
St. Jude Children's Research Hospital Memphis
Memphis, United States
Children's Medical Center
Dallas, United States
Primary Children's Hospital
Salt Lake City, United States
Seattle Children's Hospital
Seattle, United States
Trial contact
Ellynore Florendo
Suganya Rajendran
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/5/2026.
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