Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directly into the liver. HAI is already approved by the Food and Drug Administration (FDA) for use in metastatic colorectal cancer to the liver, but it is only available at a small number of hospitals, and most of the time it is not used until standard chemotherapy stops working. Standard chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Adding HAI to standard chemotherapy may be effective in shrinking or stabilizing unresectable colorectal liver metastases.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rak jelita grubego z przerzutami tylko w wątrobie, których nie można usunąć chirurgicznie
- •Brak widocznych przerzutów poza wątrobą
- •Poprzednio received 3-6 miesięcy chemioterapii pierwszej linii
- •Choroba stabilna lub reagująca na chemioterapię pierwszej linii
- •Spełnione technicze kryteria uznania raka za nieoperacyjny
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (60)
University of Alabama at Birmingham Cancer Center
Birmingham, United States
Banner MD Anderson Cancer Center
Gilbert, United States
Banner-University Medical Center Phoenix
Phoenix, United States
Banner Boswell Medical Center
Sun City, United States
UCHealth University of Colorado Hospital
Aurora, United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Northwestern University
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Memorial Hospital East
Shiloh, United States
IU Health North Hospital
Carmel, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
Mayo Clinic in Rochester
Rochester, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Roswell Park Cancer Institute
Buffalo, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
East White Plains, United States
Mount Sinai Hospital
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Duke University Medical Center
Durham, United States
Duke Cancer Center Raleigh
Raleigh, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Case Western Reserve University
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Saint Elizabeth Youngstown Hospital
Youngstown, United States
Oregon Health and Science University
Portland, United States
Lehigh Valley Hospital-Cedar Crest
Allentown, United States
Saint Vincent Hospital
Erie, United States
Jefferson Hospital
Jefferson Hills, United States
Forbes Hospital
Monroeville, United States
Fox Chase Cancer Center
Philadelphia, United States
Allegheny General Hospital
Pittsburgh, United States
West Penn Hospital
Pittsburgh, United States
Wexford Health and Wellness Pavilion
Wexford, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Parkland Memorial Hospital
Dallas, United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Trial contact
Site Public Contact
Rajesh Ramanathan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Alexis D. Leal
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jashodeep Datta
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Olumide B. Gbolahan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Shishir K. Maithel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ryan Merkow
PRINCIPAL_INVESTIGATOR
Site Public Contact
Patrick Grierson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Anita Turk
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael J. Cavnar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Benjamin D. Ferguson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kathleen Y. Butler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Cornelius A. Thiels
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Andrea Cercek
PRINCIPAL_INVESTIGATOR
Site Public Contact
Anuradha Krishnamurthy
PRINCIPAL_INVESTIGATOR
Site Public Contact
James O. Park
PRINCIPAL_INVESTIGATOR
Site Public Contact
Hope E. Uronis
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Perry Shen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alex B. Blair
PRINCIPAL_INVESTIGATOR
Site Public Contact
Howard M. Gross
PRINCIPAL_INVESTIGATOR
Site Public Contact
Skye C. Mayo
PRINCIPAL_INVESTIGATOR
Site Public Contact
Tareq Al baghdadi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Patrick L. Wagner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Vanessa Wookey
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Chandrasekhar Padmanabhan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Adam C. Yopp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Patrick Varley
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/24/2026.
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