Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Brain tumor treatment is hampered by the blood-brain barrier (BBB). This barrier prevents drugs carried in the bloodstream from getting into the brain. If the BBB can be opened, making it temporarily more permeable, drugs may able to better reach the brain tumor. In this trial we will implant a novel device with 9 ultrasound emitters, allowing temporary and reversible opening of the BBB to maximize brain penetration of drugs that modulate the immune system. The device will be implanted after radiation is completed. Immune modulating drugs will be given every 3 weeks in conjunction with activation of the device to open the BBB. The objectives of this trial are to establish whether it is safe and feasible to administer immune modulating drugs in this manner, and identify whether the treatment is effective in treating glioblastoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowo zdiagnozowany glejak mózgu (potwierdzony badaniem histologicznym)
- •Wiek 18 lat lub więcej
- •Zakończona standardowa radioterapia
- •Możliwość wykonania rezonansu magnetycznego z kontrastem
- •Guz umiejscowiony i rozmiarami dostępny dla ultradźwięków
- •Brak poprzedniej immunoterapii na tego guza
- •Dobra funkcja narządów wewnętrznych
- •Zgoda na uczestnictwo w badaniu
✗ Disqualifies
- •Wieloogniskowy nowotwór mózgu lub guz w tylnym dole czaszki
- •Niekontrolowana epilepsja
- •Historia alergii na leki podobne do tych w badaniu
- •Historia chorób autoimmunologicznych
- •Inne nowotwory w ciągu ostatnich 12 miesięcy
- •Ciąża lub karmienie piersią
- •Niekontrolowane poważne choroby
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 14, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Northwestern University
Chicago, United States
Trial contact
Neurological Surgery
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/15/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.