Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests the combination of nivolumab and ipilimumab with sirolimus and prednisone for the treatment of skin (cutaneous) cancer that cannot be removed by surgery (unresectable) or that has spread from where it first started to other places in the body (metastatic) in kidney transplant recipients. Immunotherapy with nivolumab and ipilimumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Sirolimus and prednisone are immunosuppressants that are given to keep the body from rejecting the transplanted kidney. Giving nivolumab and ipilimumab in combination with sirolimus and prednisone may kill more cancer cells, while also keeping the transplanted kidney healthy, in patients with unresectable or metastatic cutaneous cancer who have received a kidney transplant.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci po przeszczepie nerki, która działa prawidłowo i nie wymagają dializ.
- •Pacjenci mający ukończone 18 lat.
- •Potwierdzony rak skóry (czerniak nie-swoisty dla błony naczyniowej oka, rak podstawnokomórkowy, rak z komórek Merkla lub rak płaskonabłonkowy skóry), którego nie można leczyć standardowo.
- •Choroba jest mierzalna w badaniach obrazowych (np. CT, MRI).
- •Stan ogólny pacjenta pozwala na udział w badaniu (podobnie jak w przypadku zdolności do pracy w 60% lub więcej).
✗ Disqualifies
- •Pacjenci, którzy otrzymali wcześniej określone terapie przeciwnowotworowe, takie jak inhibitory BRAF/MEK dla czerniaka lub inhibitory szlaku jeżozwierza dla raka podstawnokomórkowego, jeśli mają odpowiednie mutacje.
- •Pacjenci z rakiem skóry, który może być skutecznie leczony operacyjnie, radioterapią lub chemioterapią.
- •Pacjenci przyjmujący inne leki, które mogą wpływać na wyniki badania.
- •Pacjenci z innymi chorobami nowotworowymi, które nie są związane z rakiem skóry.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 31, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (26)
UC San Diego Moores Cancer Center
La Jolla, United States
Keck Medicine of USC Koreatown
Los Angeles, United States
Los Angeles General Medical Center
Los Angeles, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
Sibley Memorial Hospital
Washington D.C., United States
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Northwestern University
Chicago, United States
Memorial Hospital East
Shiloh, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
NYU Langone Hospital - Long Island
Mineola, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
Trial contact
Site Public Contact
Soo Park
PRINCIPAL_INVESTIGATOR
Site Public Contact
Gino K. In
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Evan J. Lipson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jose Lutzky
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Sunandana Chandra
PRINCIPAL_INVESTIGATOR
Site Public Contact
George Ansstas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ruta Arays
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Maya Dimitrova
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Diwakar Davar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kathleen C. Kerrigan
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/1/2026.
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