Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will evaluate the safety and efficacy of trastuzumab deruxtecan (T-DXd) in participants with human epidermal growth factor receptor 2 (HER2)-low or HER2 immunohistochemistry (IHC) 0 (who are both hormone receptor \[HR\]-negative and HR-positive) unresectable and/or metastatic breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent wyraża zgodę na udział w badaniu i podpisuje formularz.
- •Dostarczenie próbki guza raka piersi do badań (nowej lub archiwalnej).
- •Rak piersi: nieoperacyjny lub z przerzutami.
- •Rak piersi: niski poziom HER2 (IHC 1+ lub IHC 2+/ISH-) lub brak HER2 (IHC 0).
- •Rak piersi: nigdy nie był zdiagnozowany jako HER2-pozytywny (IHC 3+ lub IHC 2+/ISH+).
- •Rak piersi: nieleczony lekami anty-HER2 w leczeniu przerzutów.
- •Pacjent otrzymał dotychczas od jednej do dwóch linii leczenia przerzutów.
- •Obecność co najmniej jednej widocznej zmiany (nowotworowej) na badaniach obrazowych.
✗ Disqualifies
- •Pacjent był wcześniej leczony terapią anty-HER2 w przypadku przerzutów.
- •Pacjent miał guzy raka piersi z wysokim poziomem HER2 (IHC 3+ lub IHC 2+/ISH+).
- •Pacjent ma zmiany przerzutowe w mózgu, które wymagają pilnego leczenia lub nie są stabilne.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 12, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (88)
Mount Sinai Medical Center
Miami Beach, United States
USF College of Medicine
Tampa, United States
Dana-Farber Cancer Institute
Boston, United States
Beth Israel Lahey Health
Burlington, United States
Overlook Medical Center
Summit, United States
Mater Hospital Sydney
North Sydney, Australia
Monash Medical Centre Moorabbin
East Bentleigh, Australia
GenesisCare St Andrews Hospital
Adelaide, Australia
Fiona Stanley Hospital
Murdoch, Australia
Institut Jules Bordet
Anderlecht, Belgium
GZA Ziekenhuizen
Antwerp, Belgium
Universitair Ziekenhuis Brussel
Brussels, Belgium
Cliniques Universitaires Saint-Luc
Brussels, Belgium
UZ Leuven
Leuven, Belgium
Centre Hospitalier Universitaire de Liege Sart-Tilman
Liège, Belgium
GZA Ziekenhuizen
Wilrijk, Belgium
Centro de Oncologia - Unidade Brasília - Hospital Sírio Libanês
Brasília, Brazil
CIONC-Centro Integrado de Oncologia de Curitiba
Curitiba, Brazil
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer
Curitiba, Brazil
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina
Florianópolis, Brazil
Oncosite - Centro de Pesquisa Clinica e Oncologia
Ijuí, Brazil
Fundação Doutor Amaral Carvalho
Jaú, Brazil
Instituto de Cancer de Londrina
Londrina, Brazil
Hospital das Clínicas FMRP-USP
Riberão Preto, Brazil
Hospital Nossa Senhora da Conceicao
Rio Grande, Brazil
Ensino e Terapia de Inovação Clínica AMO-ETICA
Salvador, Brazil
Catarina Pesquisa Clinica
Santa Catarina, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
Santo André, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
São José do Rio Preto, Brazil
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira
São Paulo, Brazil
Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda
São Paulo, Brazil
Beijing Hospital
Beijing, China
307 Hospital of PLA
Beijing, China
Fujian Cancer Hospital
Fujian, China
Sun Yat sen University Cancer Center
Guangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
Anhui Provincial Cancer Hospital
Hefei, China
Shandong Cancer Hospital
Jinan, China
Yunnan Cancer Hospital
Kunming, China
Nanchang People's Hospital
Nanchang, China
Jiangxi Cancer Hospital
Nanchang, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Fudan University Shanghai Cancer Center
Shanghai, China
Xijing Hospital (The First Affiliated Hospital of the Air Force Medical University)
Xi'an, China
Henan Cancer Hospital
Zhengzhou, China
Cork University Hospital
Cork, Ireland
St Vincent's University Hospital
Dublin, Ireland
St James Hospital
Dublin, Ireland
Beaumont Hospital
Dublin, Ireland
Galway University Hospital
Galway, Ireland
Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari
Bari, Italy
Azienda Ospedaliera Universitaria Policlinico Sant Orsola Malpighi IRCCS
Bologna, Italy
Istituto Nazionale per la Ricerca sul Cancro di Genova
Genova, Italy
Ospedale San Raffaele
Milan, Italy
Humanitas Istituto Clinico Catanese
Misterbianco, Italy
Istituto Nazionale Tumori Fondazione G Pascale
Naples, Italy
IOV - Istituto Oncologico Veneto IRCCS
Padova, Italy
Nuovo Ospedale di Prato
Prato, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
Rome, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
Ospedale Santa Chiara
Trento, Italy
Amsterdam UMC, Locatie VUMC
Amsterdam, Netherlands
Amphia Ziekenhuis Molengracht
Breda, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, Netherlands
Alrijne Ziekenhuis Leiden
Leiden, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Haga Ziekenhuis
The Hague, Netherlands
Elisabeth TweeSteden Ziekenhuis
Tilburg, Netherlands
Bernhoven Uden
Uden, Netherlands
Hospital de Braga
Braga, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE
Lisbon, Portugal
Fundação Champalimaud
Lisbon, Portugal
Centro Hospitalar de Lisboa Norte E P E Hospital de Santa Maria
Lisbon, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
Porto, Portugal
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
ICO l'Hospitalet - Hospital Duran i Reynals
Barcelona, Spain
Hospital Universitario Donostia
Donostia / San Sebastian, Spain
Hospital Universitario Virgen de las Nieves
Granada, Spain
Complejo Hospitalario Universitario Insular Materno-Infantil
Las Palmas de Gran Canaria, Spain
Hospital Beata Maria Ana
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain
Hospital General Universitario Morales Meseguer
Murcia, Spain
Clinica Universidad de Navarra
Pamplona, Spain
Complejo Hospitalario Universitario de Santiago
Santiago de Compostela, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
Hospital Arnau de Vilanova de Valencia
Valencia, Spain
Trial contact
(US Sites) Daiichi Sankyo Contact for Clinical Trial Information
(Asia Sites) Daiichi Sankyo Contact for Clinical Trial Information
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.