A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid Leukemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a phase 2 study to test the hypothesis that venetoclax in combination with standard chemotherapy will be tolerable and active in pediatric patients with newly diagnosed acute myeloid leukemia (AML). Primary Objectives: * Establish the tolerability adding venetoclax to standard chemotherapy in pediatric patients with AML * Estimate the proportion of patients who become minimal residual disease (MRD) negative by flow cytometry after one course of venetoclax-based induction therapy Secondary Objectives: \- Estimate the rates of complete remission (CR), event-free survival (EFS), and overall survival (OS) in pediatric patients who receive venetoclax-based chemotherapy
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie ostrej białaczki szpikowej potwierdzające kryteria WHO
- •Wiek powyżej 28 dni i poniżej 22 lat
- •Bez poprzedniej chemioterapii (z pewnymi wyjątkami)
- •U dziewczynek w wieku prokreacyjnym: ujemny test ciążowy
- •Dziewczęta i chłopcy w wieku rozrodczym: zgoda na antykoncepcję przez leczenie i 6 miesięcy po
- •Pisemna zgoda pacjenta i rodziców lub opiekunów prawnych
- •Prawidłowe wyniki badań wątroby
✗ Disqualifies
- •Białaczka wywołana wcześniejszym leczeniem lub zespoły genetyczne związane z brakiem szpiku
- •Zakaźnie lub poważne inne choroby zagrażające bezpieczeństwu
- •Poprzednia ekspozycja na antracykliny
- •Stosowanie silnych leków wpływających na metabolizm venetoclaxu
Simplified criteria — AI translation
Trial details
- Minimum age
- 29 Days
- Maximum age
- 21 Years
- Last updated (source)
- September 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Valley Children's Hospital
Madera, United States
Children's Hospital of Orange County
Orange, United States
Rady Children's Hospital-San Diego
San Diego, United States
Children's National Medical Center
Washington D.C., United States
Ann & Robert H. Lurie Children's Hospital
Chicago, United States
Dana-Farber Cancer Institute
Boston, United States
Novant Health Presbyterian Medical Center
Charlotte, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
St. Jude Children's Research Hospital
Memphis, United States
Cook Children's Medical Center
Fort Worth, United States
Trial contact
Hiroto Inaba, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/18/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.