A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) harboring EGFR ex20ins mutations and other mutations.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony zaawansowany rak płuca niedrobnokomórkowy z mutacją EGFR ex20ins
- •Zgoda pacjenta na uczestnictwo w badaniu (Grupa A i B)
- •Grupa A: Choroba postępiła pomimo wcześniejszego leczenia innymi lekami na tę mutację (np. amivantamab, sunvozertinib, BLU451)
- •Grupa B: Pacjent nie otrzymywał jeszcze leczenia zaawansowanego raka i nie jest kandydatem do standardowej chemioterapii
- •Jeśli są przerzuty do mózgu, muszą być stabilne i bez pogorszenia przez co najmniej 4 tygodnie
✗ Disqualifies
- •Niekontrolowane napady padacze w historii choroby
- •Rozległa choroba oponowo-móżdżkowa
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (80)
University of Alabama at Birmingham
Birmingham, United States
City of Hope - Duarte
Duarte, United States
Beth Israel Deaconess Medical Center
Boston, United States
Comprehensive Cancer Centers of Nevada - Central Valley - Twain
Las Vegas, United States
Memorial Sloan Kettering Cancer Center - Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Cancer Center - Monmouth
Middletown, United States
Memorial Sloan Kettering Cancer Center - Bergen
Montvale, United States
Memorial Sloan Kettering Cancer Center - Commack
Commack, United States
Memorial Sloan Kettering Cancer Center - Westchester
Harrison, United States
MSK Cancer Center
Long Island City, United States
Memorial Sloan Kettering Cancer Center - Nassau
Uniondale, United States
Gabrail Cancer and Research Center
Canton, United States
Zangmeister Cancer Center
Columbus, United States
The Toledo Clinic Cancer Center
Toledo, United States
SCRI Oncology Partners
Nashville, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Virginia Cancer Specialists
Fairfax, United States
IDS Pharmacy
Milwaukee, United States
Bankstown-Lidcombe Hospital
Bankstown, Australia
Genesis Care North Shore
Saint Leonards, Australia
Joondalup Hospital Pharmacy
Joondalup, Australia
William Osler Health System - Brampton Civic Hospital
Brampton, Canada
Nouvel Hôpital Civil
Strasbourg, France
Centre Leon Berard
Lyon, France
CHU Caen Normandie
Caen, France
Centre Hospitalier Universitaire Limoges
Limoges, France
Hopital Haut Leveque
Pessac, France
Hôpital Nord de Marseille
Marseille, France
Hopital Nord Laennec
Saint-Herblain, France
Hopital Ambroise Pare
Boulogne-Billancourt, France
Institut Curie
Paris, France
Gesundheit Nordhessen Holding AG
Kassel, Germany
Uniklinik Dresden
Dresden, Germany
UKGM Studienzentrale
Giessen, Germany
UKR Innere Med II Pneumologie
Regensburg, Germany
Queen Mary Hospital
Pok Fu Lam, Hong Kong
Azienda Ospedaliero - Universitaria Careggi
Florence, Italy
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
Meldola, Italy
Azienda Socio-Sanitaria Territoriale di Cremona
Cremona, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
Milan, Italy
Azienda Ospedaliero-Universitaria di Parma
Parma, Italy
Ospedale S. Maria delle Croci
Ravenna, Italy
Aichi Cancer Center
Nagoya, Japan
National Cancer Center Hospital East
Kashiwa-shi, Japan
NHO Kyushu Cancer Center
Fukuoka, Japan
Sendai Kousei Hospital
Sendai, Japan
Niigata Cancer Center Hospital
Niigata, Japan
Kindai University Hospital
Sayama, Japan
Shizuoka Cancer Center
Sunto-gun, Japan
National Cancer Center Hospital
Chuo Ku, Japan
Cancer Institute Hospital of JFCR
Koto-ku, Japan
Okayama University Hospital
Okayama, Japan
National Cancer Center - Korea
Goyang-si, South Korea
Saint Vincent's Hospital
Suwon, South Korea
Ajou University Hospital
Suwon, South Korea
Gyeongsang National University Hospital
Jinju, South Korea
Inha University Hospital
Incheon, South Korea
Chonnam National University Hwasun Hospital
Hwasun-gun, South Korea
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Seoul St. Mary's Hospital
Soeul, South Korea
Hospital Regional Universitario de Málaga - Hospital General
Málaga, Spain
UOMi Clinica Mi Tres Torres
Barcelona, Spain
Hospital Quirónsalud Barcelona
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Complejo Hospitalario de Jaen
Jaén, Spain
MD Anderson Cancer Center Madrid
Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital La Paz
Madrid, Spain
Istinye Üniversite Hastanesi Liv Hospital Bahcesehir
Esenyurt, Turkey (Türkiye)
Medical Park Seyhan Hastanesi
Adana, Turkey (Türkiye)
Trakya Üniversitesi Saglik Arastirma ve Uygulama Merkezi
Edirne, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi
Istanbul, Turkey (Türkiye)
Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, Turkey (Türkiye)
The Royal Free Hospital NHS Foundation Trust
Barnet, United Kingdom
Royal Free London NHS Foundation Trust
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Trial contact
Taiho Oncology, INC
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/2/2026.
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