SBRT Alone or Followed by Niraparib for Oligometastases or Oligoprogression in Ovarian Cancer Following PARPi Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
SOPRANO is a multi-centre phase II trial designed to assess the impact of SBRT with or without continuing treatment with a PARP inhibitor (PARPi) for patients with oligometastatic or oligoprogressive ovarian, fallopian tube and primary peritoneal carcinoma. SOPRANO will also establish the feasibility and acceptability of delivering SBRT in this setting.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony histologicznie rak jajnika, jajowodu lub otrzewnej
- •Progresja choroby podczas lub po leczeniu inhibitorem PARP, który był ostatnim lekiem systemowym
- •Minimum 6 miesięcy leczenia inhibitorem PARP wcześniej
- •Maksymalnie 3 ogniska choroby do napromieniania
- •Każde ognisko poniżej 4 cm średnicy i możliwe do napromieniania
- •Ogólny stan zdrowia pozwalający na leczenie (ECOG 0 lub 1)
- •Przewidywana przeżywalność co najmniej 6 miesięcy
✗ Disqualifies
- •Brak mierzalnej choroby (z wyjątkiem powiększonych węzłów chłonnych ≥10 mm potwierdzonej badaniami)
- •Przeciwwskazania do ponownego rozpoczęcia leczenia inhibitorem PARP
- •Planowana chirurgia z powodu nawrotu choroby
- •Dodatni test ciążowy u kobiet w wieku rozrodczym
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 13, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (7)
St James's University Hospital
Leeds, United Kingdom
Leicester Royal Infirmary
Leicester, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Western General Hospital
Edinburgh, United Kingdom
The Royal Marsden NHS Foundation Trust
Sutton, United Kingdom
University College London Hospitals
London, United Kingdom
The Royal Marsden NHS Foundation Trust
London, United Kingdom
Trial contact
Jessica Russell
Laura Moretti
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.