Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system. The goal of this discovery and exploratory study is to: * Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. * Identify risk factors for those who go on to develop side effects from immunotherapy. * Identify the molecular features associated with response and resistance to cancer therapies and immunotherapy using integrative genomic and immune repertoire characterization. * Capture and characterize systemic tumor burden by minimally invasive analyses of circulating tumor DNA. Participants may be asked to: * Donate samples of tumor, blood, lymph nodes, white blood cells, mouth cells (buccal smears) scraped from the inside of participant's cheek, urine, saliva, or other tissue samples. * Complete questionnaires about immunotherapy side effects at baseline and with follow-up appointments. * Undergo knee x-rays. * Allow the use of demographic and clinical information.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony lub podejrzewany nowotwór górnych dróg pokarmowych (głowa, szyja, płuca, gardło)
- •Kandydat do leczenia wpływającego na układ odpornościowy
- •Zdolność do zrozumienia i podpisania zgody na udział w badaniu
✗ Disqualifies
- •Zbyt niski poziom hemoglobiny w krwi uniemożliwiający pobranie krwi
- •Poważne zaburzenia krzepnięcia uniemożliwiające pobranie próbek tkanek
- •Poważne problemy z drogami oddechowymi lub sercem uniemożliwiające badanie bronchoskopowe
- •Brak możliwości czytania instrukcji w języku angielskim i wypełniania formularzy
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Johns Hopkins University
Baltimore, United States
Trial contact
Valsamo Anagnostou, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/7/2026.
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