A Study of Avutometinib and Defactinib in People With Thyroid Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The researchers are doing this study to find out if the combination of avutometinib and defactinib is an effective treatment for RAF dimer-driven radioiodine-refractory differentiated thyroid cancer or anaplastic thyroid cancer. The researchers will also test whether avutometinib and defactinib is a safe treatment that causes few or mild side effects. Funding Source- FDA OOPD.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Diagnoza raka tarczycy z potwierdzeniem genetycznym (mutacja RAS, NF1, RET, NTRK, ALK lub BRAF)
- •Wiek od 18 lat
- •Rak tarczycy w stadium przerzutów lub nawrotu, niemożliwy do operacji lub radioterapii
- •Brak ostatnich terapii - co najmniej 6 miesięcy od ostatniej terapii jodem radioaktywnym
- •Mierzalne ogniska nowotworowe widoczne w badaniach obrazowych
- •Dobry ogólny stan zdrowia (ECOG 0-1)
- •Możliwość przyjęcia dowolnej liczby poprzednich terapii
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Cancer Center Suffolk - Commack (Limited Protocol Activities)
Commack, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Rockville Centre, United States
Trial contact
Alan Ho, MD, PhD
Eric Sherman, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/16/2026.
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