A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Researchers want to find out what effects, good and/or bad, adding nivolumab to chemotherapy has on patients with newly diagnosed NPC. In addition, they want to find out if children with NPC may be treated with less radiation therapy and whether this decreases the side effects of therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek do 21 lat w momencie włączenia do badania
- •Nowo rozpoznany rak gardła nosowego stadium II-IV
- •Potwierdzenie raka przez badanie histologiczne (mikroskopowe)
- •Ogólny stan zdrowia pozwalający na leczenie - wynik ≥60%
- •Wystarczająca liczba białych krwinek (ANC ≥1000/uL)
- •Wystarczająca liczba płytek krwi (≥100 000/uL)
- •Prawidłowa funkcja nerek (klirens kreatyniny ≥60 mL/min/1,73m²)
Simplified criteria — AI translation
Trial details
- Maximum age
- 21 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (85)
Children's Hospital of Alabama
Birmingham, United States
Phoenix Childrens Hospital
Phoenix, United States
Arkansas Children's Hospital
Little Rock, United States
Kaiser Permanente Downey Medical Center
Downey, United States
Loma Linda University Medical Center
Loma Linda, United States
Children's Hospital Los Angeles
Los Angeles, United States
Valley Children's Hospital
Madera, United States
UCSF Benioff Children's Hospital Oakland
Oakland, United States
Kaiser Permanente-Oakland
Oakland, United States
Rady Children's Hospital - San Diego
San Diego, United States
UCSF Medical Center-Mission Bay
San Francisco, United States
Children's Hospital Colorado
Aurora, United States
Connecticut Children's Medical Center
Hartford, United States
Alfred I duPont Hospital for Children
Wilmington, United States
Children's National Medical Center
Washington D.C., United States
UF Health Cancer Institute - Gainesville
Gainesville, United States
Nemours Children's Clinic-Jacksonville
Jacksonville, United States
Nicklaus Children's Hospital
Miami, United States
Arnold Palmer Hospital for Children
Orlando, United States
Nemours Children's Hospital
Orlando, United States
Nemours Children's Clinic - Pensacola
Pensacola, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, United States
Lurie Children's Hospital-Chicago
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Riley Hospital for Children
Indianapolis, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
Children's Hospital New Orleans
New Orleans, United States
Maine Children's Cancer Program
Scarborough, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, United States
Dana-Farber Cancer Institute
Boston, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, United States
Mayo Clinic in Rochester
Rochester, United States
University of Mississippi Medical Center
Jackson, United States
Children's Mercy Hospitals and Clinics
Kansas City, United States
Washington University School of Medicine
St Louis, United States
Children's Hospital and Medical Center of Omaha
Omaha, United States
University of Nebraska Medical Center
Omaha, United States
Hackensack University Medical Center
Hackensack, United States
Jersey Shore Medical Center
Neptune City, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, United States
Newark Beth Israel Medical Center
Newark, United States
Albany Medical Center
Albany, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
Duke University Medical Center
Durham, United States
East Carolina University
Greenville, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Sanford Broadway Medical Center
Fargo, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
Rainbow Babies and Childrens Hospital
Cleveland, United States
Nationwide Children's Hospital
Columbus, United States
Dayton Children's Hospital
Dayton, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Lehigh Valley Hospital-Cedar Crest
Allentown, United States
Penn State Children's Hospital
Hershey, United States
Children's Hospital of Philadelphia
Philadelphia, United States
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, United States
Prisma Health Richland Hospital
Columbia, United States
BI-LO Charities Children's Cancer Center
Greenville, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Saint Jude Children's Research Hospital
Memphis, United States
The Children's Hospital at TriStar Centennial
Nashville, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Dell Children's Medical Center of Central Texas
Austin, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
Cook Children's Medical Center
Fort Worth, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, United States
UT MD Anderson Cancer Center
Houston, United States
Children's Hospital of San Antonio
San Antonio, United States
University of Virginia Cancer Center
Charlottesville, United States
Children's Hospital of The King's Daughters
Norfolk, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Seattle Children's Hospital
Seattle, United States
Mary Bridge Children's Hospital and Health Center
Tacoma, United States
Children's Hospital of Wisconsin
Milwaukee, United States
Alberta Children's Hospital
Calgary, Canada
University of Alberta Hospital
Edmonton, Canada
Hospital for Sick Children
Toronto, Canada
The Montreal Children's Hospital of the MUHC
Montreal, Canada
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Canada
Starship Children's Hospital
Grafton, New Zealand
Christchurch Hospital
Christchurch, New Zealand
University Pediatric Hospital
San Juan, Puerto Rico
Trial contact
Site Public Contact
Jamie M. Aye
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alok K. Kothari
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael W. Bishop
PRINCIPAL_INVESTIGATOR
Site Public Contact
Robert M. Cooper
PRINCIPAL_INVESTIGATOR
Site Public Contact
Albert Kheradpour
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rachana Shah
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ruetima Titapiwatanakun
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jennifer G. Michlitsch
PRINCIPAL_INVESTIGATOR
Site Public Contact
Aarati V. Rao
PRINCIPAL_INVESTIGATOR
Site Public Contact
William D. Roberts
PRINCIPAL_INVESTIGATOR
Site Public Contact
Arun A. Rangaswami
PRINCIPAL_INVESTIGATOR
Site Public Contact
Navin R. Pinto
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael S. Isakoff
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sridhi Patel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jeffrey S. Dome
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brian Stover
PRINCIPAL_INVESTIGATOR
Site Public Contact
Maggie E. Fader
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jaime M. Libes-Bander
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jeffrey H. Schwartz
PRINCIPAL_INVESTIGATOR
Site Public Contact
Don E. Eslin
PRINCIPAL_INVESTIGATOR
Site Public Contact
Amy L. Walz
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lorraine E. Canham
PRINCIPAL_INVESTIGATOR
Site Public Contact
Marissa Just
PRINCIPAL_INVESTIGATOR
Site Public Contact
James T. Badgett
PRINCIPAL_INVESTIGATOR
Site Public Contact
Maria C. Velez-Yanguas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Aaron R. Weiss
PRINCIPAL_INVESTIGATOR
Site Public Contact
Robyn D. Gartrell
PRINCIPAL_INVESTIGATOR
Site Public Contact
Allison F. O'Neill
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kathleen Y. Butler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Peter Schoettler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Amanda Strobel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Keith J. August
PRINCIPAL_INVESTIGATOR
Site Public Contact
Frederick S. Huang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jill C. Beck
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Katharine Offer
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Scott Moerdler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Teena Bhatla
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lauren R. Weintraub
PRINCIPAL_INVESTIGATOR
Site Public Contact
Alice Lee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joel A. Kaplan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jessica M. Sun
PRINCIPAL_INVESTIGATOR
Site Public Contact
Andrea R. Whitfield
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sarah Supples
PRINCIPAL_INVESTIGATOR
Site Public Contact
Samuel J. Milanovich
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brian K. Turpin
PRINCIPAL_INVESTIGATOR
Site Public Contact
Duncan S. Stearns
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mark A. Ranalli
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jordan M. Wright
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rene Y. McNall-Knapp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jacob A. Troutman
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lisa M. McGregor
PRINCIPAL_INVESTIGATOR
Site Public Contact
Theodore W. Laetsch
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brittani K. Seynnaeve
PRINCIPAL_INVESTIGATOR
Site Public Contact
Stuart L. Cramer
PRINCIPAL_INVESTIGATOR
Aniket Saha
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kayelyn J. Wagner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Catherine G. Lam
PRINCIPAL_INVESTIGATOR
Site Public Contact
Clinton M. Carroll
PRINCIPAL_INVESTIGATOR
Site Public Contact
Scott C. Borinstein
PRINCIPAL_INVESTIGATOR
Site Public Contact
Shannon M. Cohn
PRINCIPAL_INVESTIGATOR
Site Public Contact
Avanthi T. Shah
PRINCIPAL_INVESTIGATOR
Site Public Contact
Chelsee Greer
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mehmet F. Okcu
PRINCIPAL_INVESTIGATOR
Site Public Contact
Najat C. Daw
PRINCIPAL_INVESTIGATOR
Site Public Contact
Julie Voeller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brian C. Belyea
PRINCIPAL_INVESTIGATOR
Site Public Contact
Melissa S. Mark
PRINCIPAL_INVESTIGATOR
Site Public Contact
Madhu S. Gowda
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sarah E. Leary
PRINCIPAL_INVESTIGATOR
Site Public Contact
Robert G. Irwin
PRINCIPAL_INVESTIGATOR
Site Public Contact
Angela Steineck
PRINCIPAL_INVESTIGATOR
Site Public Contact
Victor A. Lewis
PRINCIPAL_INVESTIGATOR
Site Public Contact
Sarah J. McKillop
PRINCIPAL_INVESTIGATOR
Site Public Contact
Avram E. Denburg
PRINCIPAL_INVESTIGATOR
Site Public Contact
Stephanie Mourad
PRINCIPAL_INVESTIGATOR
Site Public Contact
Monia Marzouki
PRINCIPAL_INVESTIGATOR
Site Public Contact
Josee Brossard
PRINCIPAL_INVESTIGATOR
Site Public Contact
Leander D. Timothy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Tristan Pettit
PRINCIPAL_INVESTIGATOR
Site Public Contact
Maria E. Echevarria
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/10/2026.
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