Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial evaluates apalutamide in combination with image-guided stereotactic body radiation therapy (SBRT) for the treatment of patients with prostate cancer. Prostate cancer usually needs the hormone testosterone to grow. Apalutamide is a hormone therapy that blocks the effect of testosterone on prostate tumor cells. This may help stop the growth of tumor cells that need testosterone to grow. Image-guided SBRT is a standard treatment for some types of prostate cancer. This treatment combines imaging of cancer within the body, with the delivery of therapeutic radiation doses produced on a linear accelerator machine. SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Combining apalutamide with image-guided SBRT may increase a prostate cancer patient's chances of achieving an extremely low prostate specific antigen response, which is an early predictor of disease cure.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnoza raka gruczołu krokowego (prostatowego)
- •Wiek 18 lat lub więcej
- •Rak prostaty zaklasyfikowany jako niekorzystny pośredni (wraz z określonymi parametrami PSA, stadium i градацией komórek)
- •Obecność głównego ogniska nowotworu widocznego na rezonansie magnetycznym
- •Wykonane badanie PET/CT z markerem PSMA
- •Poziom testosteronu powyżej 150 ng/dL
- •Wystarczająca ogólna wydolność organizmu do tolerowania leczenia
- •Prawidłowe wyniki badań krwi (hemoglobina, płytki krwi, funkcja wątroby i nerek)
✗ Disqualifies
- •Objawy uciśnięcia rdzenia kręgowego
- •Wcześniejszy nowotwór w okolicy miednicy
- •Wcześniejsza radioterapia pelviczna
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 17, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (1)
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, United States
Trial contact
Christy Palodichuk
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/18/2026.
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