RecruitingPhase IIIEN originalBreast cancerMetastatic / advanced

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a multicenter randomized, open label study to evaluate overall survival with the Bria-IMT regimen in combination with Checkpoint Inhibitor \[Retifanlimab\], versus Treatment of Patients'/Physicians' Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with no approved alternative therapies available.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek co najmniej 18 lat
  • Podpisana świadoma zgoda na udział w badaniu
  • Potwierdzone histologicznie raka piersi z przerzutami lub nawrotem miejscowym, który nie poddaje się leczeniu lokalnym, oraz wcześniejsze niepowodzenie leczenia
  • Oczekiwana przeżywalność co najmniej 4 miesiące
  • Stan ogólny według skali ECOG: 0, 1 lub 2

✗ Disqualifies

  • Chemioterapia, immunoterapia lub duża operacja w ciągu 21 dni przed pierwszą dawką leku
  • Radioterapia w ciągu 14 dni przed pierwszą dawką leku
  • Niepowrócone efekty uboczne wcześniejszego leczenia (z wyjątkiem wypadania włosów i niedokrwistości niezagrażającej życiu)
  • Ciężkie działania niepożądane (stopień 3 lub wyższy) z poprzedniej immunoterapii, chyba że zostały pomyślnie leczone
  • Niepowrócone działania niepożądane z poprzedniej immunoterapii do stopnia 1 lub niżej

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
April 7, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (79)

Mayo Clinic-Comprehensive Cancer Center-Breast Clinic

Phoenix, United States

University of Arizona-Cancer Center

Tucson, United States

Los Angeles cancer Network_Anaheim

Anaheim, United States

Comprehensive Blood and Cancer Center

Bakersfield, United States

Cedars-Sinai Cancer Beverly Hills

Beverly Hills, United States

Los Angeles Cancer Network_Corona

Corona, United States

Los Angeles cancer Network_Fountain Vallley

Fountain Valley, United States

Los Angeles Cancer Network_Glendale

Glendale, United States

Hoag Hospital Center

Irvine, United States

Hoag Hospital Irvine

Irvine, United States

Los Angeles Cancer Network

Los Angeles, United States

Cedars-Sinai Cancer at Cedars-Sinai Medical Facility

Los Angeles, United States

Los Angeles Cancer Network_Century City

Los Angeles, United States

UCLA-Hematology/Oncology Medical Plaza

Los Angeles, United States

UCLA-Hematology/Oncology_LA 2

Los Angeles, United States

UCLA-Hematology/Oncology_LA

Los Angeles, United States

Los Angeles Cancer Network_Pasadena

Pasadena, United States

Los Angeles cancer Network_Riverside

Riverside, United States

UC San Diego

San Diego, United States

St. John's Cancer Center

Santa Monica, United States

UCLA-Department of Medicine Hematology/Oncology-Parkside

Santa Monica, United States

UCLA-Hetamtology/Oncology_S Monica

Santa Monica, United States

Torrance Memorial Cancer Center

Torrance, United States

Los Angeles Cancer Network_Valley Pres

Van Nuys, United States

Cedars-Sinai Breast Health Services Building

West Hollywood, United States

Smilow Cancer Hospital at Yale New Haven

New Haven, United States

University of Miami _SCCC - Aventura

Aventura, United States

University of Miami-SCCC-Lennar

Coral Gables, United States

University of Miami_SCCC-Coral Springs

Coral Springs, United States

University of Miami Hospital and Clinics - Deerfield Beach

Deerfield Beach, United States

University of Miami_SCCC-Hollywood

Hollywood, United States

Mayo Clinic Florida-Comprehensive Cancer Center

Jacksonville, United States

University Of Miami-SCCC-Miami

Miami, United States

University of Miami_SCCC - Kendall

Miami, United States

Advent Health - Orlando

Orlando, United States

University of Miami-SCCC-Plantation

Plantation, United States

Winship Cancer Institute of Emory University

Atlanta, United States

Northwestern University

Chicago, United States

Southern Illinois University-Simmons

Springfield, United States

Carle Foundation Cancer Institute-Urbana

Urbana, United States

Northwest Cancer Center

Dyer, United States

AMR Kansas City Oncology

Kansas City, United States

Care Access-Marrero

Marrero, United States

The Center for Cancer and Blood Disorders a division of American Oncology Partners, P.A.

Bethesda, United States

Mayo Clinic-Comprehensive Cancer Center-Breast Clinic

Rochester, United States

Nebraska Cancer Specialists

Omaha, United States

Dartmouth Hitchcock Medical Center

Lebanon, United States

Hunterdon Medical Center

Flemington, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C. (Babylon)

Babylon, United States

NYU Langone's Perlmutter Cancer Center

Manhattan, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C.(New Hyde Park)

New Hyde Park, United States

Manhattan Hematology /Oncology Associates

New York, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C (NY)

New York, United States

New York Cancers & Blood Specialists_North Shore Hematology Oncology Assocaites P.C (Patchogue)

Patchogue, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C. (Port Jefferson Station2)

Port Jefferson Station, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C.(Port Jefferson Station1)

Port Jefferson Station, United States

New York Cancers & Blood Specialists

Port Jefferson Station, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C. (Riverhead)

Riverhead, United States

New York Cancer and Blood Specialists_North Shore Hematology Oncology Assocaites P.C (Brox)

The Bronx, United States

Regional Medical Oncology Center_Wlson

Wilson, United States

Gabrail Cancer & Research Center

Canton, United States

Cleveland Clinic

Cleveland, United States

Texas Oncology-Baylor Charles A. Sammons Cancer Center

Dallas, United States

Mary Crowley Cancer Research

Dallas, United States

DHR Health Oncology Institute

Edinburg, United States

Texas Oncology - Fredericksburg

Fredericksburg, United States

Texas Oncology - Harlingen

Harlingen, United States

Texas Oncology McAllen

McAllen, United States

Texas Oncology, New Braunfels

New Braunfels, United States

Texas Oncology-San Antonio Cancer Care

San Antonio, United States

Texas Oncology - San Antonio Northeast

San Antonio, United States

Texas Oncology - San Antonio Stone Oak

San Antonio, United States

Tranquil Clinical Research

Webster, United States

Texas Oncology - Weslaco

Weslaco, United States

Hematology-Oncology Associates of Fredericksburg, Inc

Fredericksburg, United States

Cancer Care Northwest-1 (601 S. Sherman)

Spokane, United States

Cancer Care Northwest_2 (605 E. Holland)

Spokane, United States

Cancer Care Northwest

Spokane Valley, United States

Sheboygan Cancer & Blood Specialists

Sheboygan, United States

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.

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