Predicting BReast cAncer Response to neoadjuVant Therapy by ctDNA Assessment
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a prospective and observational study, aiming to determine the detection rate and change of CtDNA in blood samples of cancer patients before, during and after neoadjuvant treatment. * Determine the rate of ctDNA positivity at the time before treatment, * Determine the rate of ctDNA positivity at the time during treatment, * Determine the rate of ctDNA positivity at the time after neoadjuvant therapy, whether there is a change in ctDNA expression of the study population during treatment. And aiming to investigate the relationship between ctDNA expression and MRI imaging with pCR response in neo-adjuvant therapy: * Correlation between ctDNA detection and pCR response. Determine the percentage of Positive Prediction Value - PPV, Negative Prediction Value - NPV of ctDNA, * Correlation between MRI imaging and pCR response. Determination of PPV, NPV of MRI * Combination of ctDNA detection and MRI imaging in the prognosis of pCR. Determination of PPV, NPV ratio of ctDNA combined with MRI.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobiety w wieku 18 lat i starsze.
- •Zdiagnozowany rak piersi HER2+/potrójnie negatywny w stopniu II-III, który kwalifikuje się do leczenia przedoperacyjnego.
- •Dostępna jest próbka tkanki raka z momentu diagnozy lub operacji.
✗ Disqualifies
- •Nawrót raka piersi.
- •Przerzuty innych nowotworów do piersi.
- •Pacjentki, które już były lub są leczone na inne nowotwory.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 23, 2025
- Sex
- Female only
Locations (3)
MRCCC Siloam Hospitals Semanggi
Jakarta, Indonesia
Medical Genetics Institute
Ho Chi Minh City, Vietnam
University Medical Center HCMC
Ho Chi Minh City, Vietnam
Trial contact
Lan NL Tu, PHD
Van T. Phan, MSc
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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