RecruitingPhase I/IIEN originalLymphoma

A Study to Assess BMS-986458 Alone and in Combination With Anti-lymphoma Agents in Relapsed/Refractory Non-Hodgkin Lymphomas

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary biological and clinical activity of BMS-986458, a bifunctional cereblon-dependent ligand-directed degrader of B-cell lymphoma 6 (BCL6), as a single agent and in combination with anti-lymphoma agents in participants with relapsed/refractory non-Hodgkin Lymphoma.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek co najmniej 18 lat
  • Chłoniak nieziarniczy, który powrócił lub nie reaguje na wcześniejsze leczenie
  • Widoczne guzy dające się zmierzyć w badaniach obrazowych
  • Zgoda na stosowanie antykoncepcji podczas badania

✗ Disqualifies

  • Zły stan ogólny pacjenta uniemożliwiający uczestnictwo
  • Niezdolność do przestrzegania zasad badania
  • Wcześniejsze leczenie poprzez specjalne komórki CAR-T lub napromienianie w ciągu ostatnich 4 tygodni
  • Przeszczep szpiku kostnego lub narządu w ciągu ostatnich 3-6 miesięcy
  • Zajęcie mózgu przez nowotwór
  • Aktywna lub niekontrolowana infekcja

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 18, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (73)

Mayo Clinic in Arizona - Phoenix

Phoenix, United States

City of Hope Comprehensive Cancer Center

Duarte, United States

Local Institution - 0068

Jacksonville, United States

Moffitt Cancer Center

Tampa, United States

Dana-Farber Cancer Institute

Boston, United States

Mayo Clinic in Rochester, Minnesota

Rochester, United States

Local Institution - 0124

Omaha, United States

Local Institution - 0047

Lake Success, United States

Local Institution - 0037

New York, United States

Memorial Sloan Kettering Cancer Center

New York, United States

Local Institution - 0045

Providence, United States

Local Institution - 0118

Antofagasta, Chile

Local Institution - 0105

Santiago, Chile

Local Institution - 0109

Santiago, Chile

Beijing Cancer hospital

Beijing, China

Local Institution - 0084

Guangzhou, China

Local Institution - 0087

Zhengzhou, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

Local Institution - 0130

Nanchang, China

Local Institution - 0131

Shanghai, China

Local Institution - 0128

Hangzhou, China

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux, France

Local Institution - 0125

Lyon, France

Hopital Claude Huriez - CHU de Lille

Lille, France

Gustave Roussy

Villejuif, France

Henri Mondor Hospital

Créteil, France

CHU SAINT ELOI - Departement Hematologie Clinique

Montpellier, France

Hôpital Saint-Louis

Paris, France

Institut Claudius Regaud

Toulouse, France

Universitätsklinikum Münster - Albert Schweitzer Campus

Münster, Germany

Universitaetsklinikum des Saarlandes

Homburg, Germany

Universitätsklinikum Leipzig

Leipzig, Germany

Helios Klinikum Berlin-Buch

Berlin, Germany

Universitaetsklinikum Essen

Essen, Germany

Local Institution - 0103

Pátrai, Greece

Local Institution - 0107

Athens, Greece

Local Institution - 0102

Athens, Greece

Local Institution - 0119

Hong Kong, Hong Kong

Local Institution - 0094

Bologna, Italy

Local Institution - 0116

Brescia, Italy

Local Institution - 0098

Milan, Italy

Local Institution - 0113

Milan, Italy

Local Institution - 0112

Pisa, Italy

Local Institution - 0111

Ravenna, Italy

Local Institution - 0115

Roma, Italy

Local Institution - 0110

Roma, Italy

Local Institution - 0097

Verona, Italy

Local Institution - 0090

Nagoya, Japan

Local Institution - 0091

Chuo-ku, Japan

University of Yamanashi Hospital

Chūō, Japan

Local Institution - 0092

Fukuoka, Japan

Maastricht UMC+

Maastricht, Netherlands

Local Institution - 0121

Amsterdam, Netherlands

University Medical Center Groningen

Groningen, Netherlands

Local Institution - 0077

Seoul, South Korea

Local Institution - 0123

Seoul, South Korea

Local Institution - 0078

Seoul, South Korea

Hospital Universitario Virgen de la Victoria

Málaga, Spain

Hospital Universitari Vall d'Hebron

Barcelona, Spain

Hospital General Universitario Gregorio Marañon

Madrid, Spain

Clinica Universidad de Navarra

Pamplona, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Spain

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

Salamanca, Spain

Ospedale Regionale Bellinzona e Valli

Bellinzona, Switzerland

University Hospital Basel

Basel, Switzerland

Hopitaux Universitaires de Geneve (HUG)

Geneva, Switzerland

Local Institution - 0096

Ankara, Turkey (Türkiye)

Local Institution - 0101

Ankara, Turkey (Türkiye)

Local Institution - 0099

Istanbul, Turkey (Türkiye)

Local Institution - 0122

Istanbul, Turkey (Türkiye)

Local Institution - 0071

Southampton, United Kingdom

Local Institution - 0081

Manchester, United Kingdom

Local Institution - 0072

Edinburgh, United Kingdom

Trial contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

First line of the email MUST contain NCT # and Site #.

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.

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