A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is researching an experimental drug called odronextamab, referred to as study drug. The study is focused on participants with previously untreated follicular lymphoma (a type of non-Hodgkin lymphoma or NHL). This study will be made up of two parts: Part 1 (non-randomized) and Part 2 (randomized - controlled). The aim of Part 1 of the study is to see how safe and tolerable the study drug is when given alone. The aim of Part 2 of the study is to see how the study drug works compared to rituximab (called the "comparator drug") and chemotherapy (the current standard of care for NHL). Standard of care means the usual medication expected and used when receiving treatment for a condition. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) * How the study drug affects quality of life and ability to complete routine daily activities.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie chłoniaka folikularnego CD20+ stopnia 1-3a, w stadium II (powiększone węzły) lub III/IV
- •Potrzeba rozpoczęcia leczenia
- •Widoczne zmiany chorobowe w badaniach obrazowych (CT lub MRI)
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu
- •Prawidłowe funkcjonowanie szpiku kostnego i wątroby
✗ Disqualifies
- •Chłoniak w mózgu lub błonach mózgu
- •Transformacja do bardziej agresywnego rodzaju chłoniaka
- •Inne typy chłoniaków lub białaczka
- •Poprzednie leczenie przeciwko chłoniakowi
- •Aktywne infekcje lub uczulenie na badany lek
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (190)
University of Arizona Cancer Center
Tucson, United States
David Geffen School of Medicine at UCLA
Los Angeles, United States
UC Irvine Health
Orange, United States
Investigative Clinical Research of Indiana
Noblesville, United States
Beth Israel Deaconess Medical Center
Boston, United States
Karmanos Cancer Institute
Detroit, United States
Hattiesburg Clinic
Hattiesburg, United States
Icahn School of Medicine at Mt Sinai
New York, United States
Stony Brook University Hospital
Stony Brook, United States
Clinical Research Alliance Inc
Westbury, United States
University of North Carolina
Chapel Hill, United States
Levine Cancer Institute
Charlotte, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
Vanderbilt University Medical Center
Nashville, United States
Center for Oncology and Blood Disorders
Houston, United States
HOPE Cancer Center of East Texas
Tyler, United States
Huntsman Cancer Institute - Oncology Division
Salt Lake City, United States
University of Virginia
Charlottesville, United States
Virginia Commonwealth University
Richmond, United States
Prohealth Care Inc
Waukesha, United States
Ingham Institute
Liverpool, Australia
Icon Cancer Centre - Wesley
Auchenflower, Australia
Flinders Medical Centre
Bedford Park, Australia
Monash Health
Clayton, Australia
Epworth Freemasons
East Melbourne, Australia
St Vincent's Hospital - Melbourne
Fitzroy, Australia
Alfred Hospital and Monash University
Melbourne, Australia
Ordensklinikum Linz
Linz, Austria
Ordensklinikum Linz Gmbh, Elisabethinen
Linz, Austria
Uniklinikum Salzburg (LKH) Universitatsklinik fur Innere Medizin III
Salzburg, Austria
Medical University of Vienna
Vienna, Austria
Hanusch Krankenhaus
Vienna, Austria
AZ St.-Elisabeth Herentals vzw
Herentals, Belgium
Hopital De Jolimont
La Louvière, Belgium
Universitair Ziekenhuis (UZ) Gent/ Ghent University Hospital
Ghent, Belgium
Ziekenhuis Netwerk Antwerpen Stuivenberg
Antwerp, Belgium
Institut Jules Bordet
Brussels, Belgium
Ensino e Terapia de Inovacao Clinica Amo (Etica)
Salvador, Brazil
Instituto Mario Pena de Ensino Pesquisa e Inovacao
Belo Horizonte, Brazil
Liga Norte Riograndense Contra o Cancer
Natal, Brazil
Instituto do Cancer em Hospital Sao Vicente de Paulo
Passo Fundo, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Brazil
Centro de Hematologia e Oncologia
Joinville, Brazil
Animi Unidade de Tratamento Oncologico Ltda
Lages, Brazil
Fundacao Pio XII Hospital de Amor
Barretos, Brazil
Amaral Carvalho Hospital
Jaú, Brazil
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo
Ribeirão Preto, Brazil
Instituto DOr de Pesquisa e Ensino Df Star
Brasília, Brazil
Instituto Nacional de Cancer Jose Alencar Gomes da Silva
Rio de Janeiro, Brazil
Instituto Americas
Rio de Janeiro, Brazil
Hospital Alemao Oswaldo Cruz
São Paulo, Brazil
AC Camargo Cancer Center
São Paulo, Brazil
Clinical Hospital of Medicine School at Sao Paulo University
São Paulo, Brazil
Casa de Saude Santa Marcelina
São Paulo, Brazil
Tom Baker Cancer Center
Calgary, Canada
Saint John Regional Hospital
Saint John, Canada
Centre Integre de Sante et de Services Sociaux (CISSS) de la Monteregie-Centre
Greenfield Park, Canada
CHU de Quebec - Universite Laval
Québec, Canada
Ciusss de Lestrie - Centre Hospitalier Universitaire de Sherbrooke (CHUS)
Sherbrooke, Canada
Fundacion Arturo Lopez Perez
Santiago, Chile
Centro Oncologia de Precision Universidad Mayor
Santiago, Chile
Inmunocel
Santiago, Chile
Clinica Alemana de Santiago
Santiago, Chile
University Hospital Hradec Kralove
Hradec Králové, Czechia
University Hospital Kralovske Vinohrady
Prague, Czechia
Vseobecna Fakultni Nemocnice
Prague, Czechia
Centre Hospitalier Universitaire (CHU) Rennes
Rennes, France
Centre Hospitalier Regional Universitaire de Tours
Tours, France
Nantes University Hospital
Nantes, France
Hopital de la Conception
Marseille, France
Centre Hospitalier Universitaire (CHU) de Poitiers
Poitiers, France
Centre Hospitalier Universitaire Angers
Angers, France
Institut Paoli Calmettes
Marseille, France
Hopital Saint Louis
Paris, France
Hopital Saint-Antoine
Paris, France
Institut de Cancerologie Strasbourg Europe (ICANS)
Strasbourg, France
Hopital Victor Dupouy Argenteuil
Argenteuil, France
Gustave Roussy
Villejuif, France
Robert-Bosch-Krankenhaus
Stuttgart, Germany
University Hospital Wurzburg
Würzburg, Germany
Kliniken Ostalb Stauferklinikum Schwab Gmund
Mutlangen, Germany
Clinic Frankfurt (Oder)
Frankfurt am Main, Germany
Universitatsmedizin der Johannes-Gutenberg Universitat Mainz
Mainz, Germany
Hematological Praxis Dresden
Dresden, Germany
Charite Universitatsmedizin Berlin Campus Benjamin Franklin
Berlin, Germany
University Hospital Carl Gustav Carus
Dresden, Germany
Stadtisches Krankenhaus Kiel
Kiel, Germany
Samson Assuta Ashdod University Hospital
Ashdod, Israel
Bnai Zion Medical Center
Haifa, Israel
Hadassah Medical Center
Jerusalem, Israel
Galilee Medical Center
Nahariya, Israel
Rabin Medical Center
Petah Tikva, Israel
Chaim Sheba Medical Center
Ramat Gan, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Istituto Romagnolo Per Lo Studio Dei Tumori
Meldola, Italy
Pia Fondazione Panico
Tricase, Italy
IRCCS Ospedale Policlinico San Martino
Genoa, Italy
Candiolo Cancer Institute, FPO, IRCCS
Candiolo, Italy
UOC Ematologia e Terapia Cellulare - PO Mazzoni AST Ascoli Piceno
Ascoli Piceno, Italy
Irccs Aou Di Bologna - Policlinico Di Sant'orsola Malpighi
Bologna, Italy
Azienda Ospedaliera Spedali Civili di Brescia
Brescia, Italy
Istituto Europeo di Oncologia
Milan, Italy
Federico II University
Naples, Italy
AOU Maggiore della Carita-SCDU Ematologia
Novara, Italy
UO Ematologia Ravenna
Ravenna, Italy
Santa Maria della Misericordia
Udine, Italy
Ospedale dell'Angelo - Varese
Varese, Italy
Specjalistyczny Szpital im A. Sokolowskiego w Walbrzychu
Wałbrzych, Poland
Uniwersytecki Szpital Kliniczny
Wroclaw, Poland
Pratia MCM Krakow
Krakow, Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Aidport
Skorzewo, Poland
Cm Pratia Poznan
Skorzewo, Poland
Pratia Onkologia Katowice
Katowice, Poland
Copernicus Memorial Hospital
Lodz, Poland
Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Lublin, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Warszawa
Warsaw, Poland
Center for Hematologic Malignancy
Goyang-si, South Korea
St. Vincents Hospital - The Catholic University of Korea
Suwon, South Korea
Ajou University Hospital
Suwon, South Korea
Jeonbuk National University Hospital
Jeonju, South Korea
Dong-A University Hospital
Busan, South Korea
Pusan National University Hospital
Busan, South Korea
Kyungpook National University Chilgok Hospital
Daegu, South Korea
Seoul St. Mary's Hospital
Seoul, South Korea
University Hospital of Santiago de Compostela
Santiago de Compostela, Spain
Hospital Universitario Virgen De La Victoria Malaga
Málaga, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Son Espases University Hospital
Palma, Spain
Cruces University Hospital (Hospital Universitario Cruces)
Barakaldo, Spain
Hospital Universitario Marques de Valdecilla
Santander, Spain
Complejo Hospitalario Universitario de a Coruna
A Coruña, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain
Hospital Clinico Universitario Virgen De La Arrixaca
El Palmar, Spain
Hospital Universitario de Navarra
Pamplona, Spain
Hospital Universitario Central de Asturias
Oviedo, Spain
University Hospital Vall d'Hebron
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Virgen De Las Nieves De Granada
Granada, Spain
Gregorio Maranon
Madrid, Spain
Clinica Universidad de Navarra
Madrid, Spain
Clinica Universidad de Navarra
Madrid, Spain
Fundacion Jimenez Diaz University Hospital
Madrid, Spain
University Hospital & Research Institute
Madrid, Spain
Hospital Universitario HM Sanchinarro, Servicio de Hematologia
Madrid, Spain
Morales Meseguer Hospital
Murcia, Spain
Complexo Hospitalario Universitario de Ourense
Ourense, Spain
Hospital Universitario de Salamanca
Salamanca, Spain
University Hospital Virgen del Rocio
Seville, Spain
Hospital Universitario Virgen de Valme
Seville, Spain
Hospital General Universitario de Toledo
Toledo, Spain
Hospital Clinico Universitario Valencia
Valencia, Spain
Hospital Universitari and Politecnic La Fe
Valencia, Spain
Hospital Clinico Lozano Blesa
Zaragoza, Spain
Kantonsspital Baden
Baden, Switzerland
Cantonal Hospital St Gallen
Sankt Gallen, Switzerland
Kantonsspital Winterthur Medical Oncology
Winterthur, Switzerland
University Hospital Basel
Basel, Switzerland
Inselspital Bern University Hospital
Bern, Switzerland
Chang Gung Medical Foundation Chia Yi Branch
Buzi, Taiwan
Chang Gung Memorial Hospital Linkou
Taoyuan City, Taiwan
Changhua Christian Hospital
Changhua, Taiwan
Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Taipei Medical University-Shuang Ho Hospital
New Taipei City, Taiwan
Taichung General Veterans Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Tri-Service General Hospital
Taipei, Taiwan
Taipei Municipal Wan Fang Hospital
Taipei, Taiwan
Ankara University Faculty of Medicine
Mamak, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
Yenimahalle, Turkey (Türkiye)
Gazi University
Ankara, Turkey (Türkiye)
VM Medical Park Mersin Hospital
Mezitli, Turkey (Türkiye)
Tekirdag Namik Kemal University Hospital
Tekirdağ, Turkey (Türkiye)
Liv Hospital Ankara
Ankara, Turkey (Türkiye)
VKV American Hopital
Istanbul, Turkey (Türkiye)
Istanbul University Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye)
Ege University
Izmir, Turkey (Türkiye)
Erci̇yes Uni̇versi̇ty
Kayseri, Turkey (Türkiye)
Sakarya University Medical Faculty
Sakarya, Turkey (Türkiye)
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun, Turkey (Türkiye)
Zonguldak Bulent Ecevit University
Zonguldak, Turkey (Türkiye)
Royal Cornwall Hospitals NHS Trust, Royal Cornwall Hospital
Truro, United Kingdom
Derriford Hospital and the Royal Eye Infirmary
Plymouth, United Kingdom
University Hospitals Dorset
Bournemouth, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
Norfolk and Norwich University Hospital
Norwich, United Kingdom
Barking, Havering and Redbridge University Hospitals NHS Trust
Romford, United Kingdom
Trial contact
Clinical Trials Administrator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/11/2026.
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