Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The Study is a Phase 3, randomized, three-arm, double-blind, placebo-controlled, multi-regional clinical research study to evaluate the safety and efficacy use of toripalimab alone or in combination with tifcemalimab as consolidation therapy in patients with limited-stage small cell lung cancer without disease progression following chemoradiotherapy. Tifcemalimab is a monoclonal antibody against B and T lymphocyte attenuator (BTLA). Toripalimab is a monoclonal antibody against programmed death protein-1 (PD-1). Neither drug is approved for treatment of This combination regimen is investigational in limited stage-small cell lung cancer in any country.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rak płuc małokomórkowy w ograniczonym stopniu zaawansowania
- •Otrzymanie chemioterapii i radioterapii (co najmniej 4 cykle chemioterapii i dawka promieniowania 60-66 Gy)
- •Brak pogorszenia się choroby po chemioterapii i radioterapii
- •Dobry ogólny stan zdrowia (wynik 0-1 w skali ECOG)
- •Prawidłowe funkcjonowanie organów wewnętrznych
- •Chęć uczestnictwa i podpisanie zgody na badanie
✗ Disqualifies
- •Mieszany typ raka płuc (małokomórkowy i inny)
- •Poprzednia sekwencyjna chemioterapia i radioterapia
- •Brak wyzdrowienia z powikłań poprzedniej terapii
- •Aktywna choroba autoimmunologiczna lub historia choroby autoimmunologicznej
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (76)
Harbin Medical University Cancer Hospital
Harbin, China
Xiangya Hospital Central South University
Changsha, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
The First Hospital of China Medical University
Shenyang, China
Shandong Cancer Hospital & Institute
Jinan, China
Anyang Tumor Hospital
Anyang, China
Beijing Cancer Hospital
Beijing, China
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China
Jilin Cancer Hospital
Changchun, China
Hunan Cancer Hospital
Changsha, China
Sichuan cancer hospital
Chengdu, China
Chongqing University Cancer Hospital
Chongqing, China
Peking University Shenzhen Hospital
Guangdong, China
Sun Yat-sen University Cancer Center
Guangzhou, China
No. 1 Bandong Road, Gongshu District, Hangzhou
Hangzhou, China
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, China
The First Affiliated Hospital of Ustc
Hefei, China
Henan Cancer Hospital
Henan, China
Affiliated Hospital of Jining Medical University
Jining, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Fudan University Shanghai Cancer Center
Shanghai, China
Liaoning cancer hospital
Shenyang, China
Shanxi Cancer hospital
Taiyuan, China
Taizhou Hospital of Zhejiang Province
Taizhou, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Hubei Cancer Hospital (Hubei Cancer Research Institute)
Wuhan, China
Zhongnan Hospital of Wuhan University
Wuhan, China
The First Affiliated Hospital of Xiamen University
Xiamen, China
General Hospital of Ningxia Medical University
Yinchuan, China
ISR-GEO Med Res Clin Healthycore
Tbilisi, Georgia
Ltd New Hospitals
Tbilisi, Georgia
Multprofil Clinic Consilium Medulla
Tbilisi, Georgia
Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic
Tbilisi, Georgia
"TIM - Tbilisi Institute of Medicine" LTD
Tbilisi, Georgia
ICO-Institute of Clinical Oncology - Hospital
Tbilisi, Georgia
LTD "Israel-Georgian Medical Research Clinic Healthycore"
Tbilisi, Georgia
LTD "New Hospitals"
Tbilisi, Georgia
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
Rijnstate Ziekenhuis
Arnhem, Netherlands
Erasmus Medisch Centrum
Rotterdam, Netherlands
Isala Klinieken Zwolle
Zwolle, Netherlands
Complexo Hospitalario Universitario A Coruña
A Coruña, Spain
Hospital Universitari Dexeus Grupo Quironsalud
Barcelona, Spain
Complejo Hospitalario de Jaén
Jaén, Spain
Fundacion Jimenez Diaz
Madrid, Spain
Hospital Clínico San Carlos
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Donostia
San Sebastián, Spain
H.C.U.Lozano Blesa
Zaragoza, Spain
Hospital Unviersitario Miguel Servet
Zaragoza, Spain
Taipei Veterans General Hospital
Taipei City, Taiwan
No.123,DAPI Rd. Niaosong Dist, Kaohsiung City 83301 Taiwan, R.O.C.
Kaohsiung City, Taiwan
China Medical University Hospital - Internal Medicine - Taichung
Taichung, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
Chi Mei Hospital, Liouying - Department of Oncology
Tainan, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital - Internal Medicine
Taipei, Taiwan
Taipei Medical University - Shuang Ho Hospital
Taipei, Taiwan
Taipei Medical University - Taipei Medical University Hospital
Taipei, Taiwan
Taipei Medical University - WanFang Hospital - Hematology and Oncology
Taipei, Taiwan
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital
Taoyuan, Taiwan
Ankara City Hospital
Ankara, Turkey (Türkiye)
Ankara Liv Hospital
Ankara, Turkey (Türkiye)
Gulhane Training and Research Hospital - Medical Oncology
Ankara, Turkey (Türkiye)
Memorial Ankara Hospital
Ankara, Turkey (Türkiye)
Trakya University Medical Faculty
Edirne, Turkey (Türkiye)
Bakirköy Dr. Sadi Konuk Eğitim ve Araştirma Hastanesi - Oncology
Istanbul, Turkey (Türkiye)
Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital - Medical Oncology
Istanbul, Turkey (Türkiye)
Ege University Medical Faculty - Pulmonary
Izmir, Turkey (Türkiye)
İzmir Ekonomi Üniversitesi Medical Point İzmir Hastanesi
Izmir, Turkey (Türkiye)
Katip Celebi University Ataturk Research and Training Hospit
Izmir, Turkey (Türkiye)
Kocaeli University Research and Practice Hospital
Kocaeli, Turkey (Türkiye)
Necmettin Erbakan University Meram
Konya, Turkey (Türkiye)
Inonu University Turgut Ozal Medical Center
Malatya, Turkey (Türkiye)
Trial contact
kui zhang, Project Directer
Kinga Kovacs, Senior Project Leader
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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