RecruitingPhase IIEN original

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The purpose of this study is to assess the safety of atezolizumab and bevacizumab, or atezolizumab alone, as first-line treatment in participants with unresectable, locally advanced or metastatic hepatocellular carcinoma (HCC) with Child-pugh B7 or B8 cirrhosis.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Rak wątroby w zaawansowanym stadium, którego nie można leczyć operacyjnie ani innymi miejscowymi terapiami.
  • Brak wcześniejszego leczenia ogólnego (w tym eksperymentalnymi lekami) na raka wątroby w zaawansowanym stadium.
  • Rak wątroby widoczny na badaniach obrazowych (przynajmniej jedna zmiana docelowa, która nie była leczona).
  • Stan ogólny pacjenta pozwala na udział w badaniu (zgodnie ze skalą ECOG 0-2).
  • Marskość wątroby typu Child-Pugh B7 lub B8.
  • Odpowiednia liczba komórek krwi i prawidłowe funkcjonowanie narządów.
  • Przewidywana długość życia co najmniej 12 tygodni.
  • Kobiety w wieku rozrodczym muszą zgadzać się na unikanie ciąży i oddawania komórek jajowych.

✗ Disqualifies

  • Ciąża lub karmienie piersią.
  • Wcześniejsze leczenie lekami wpływającymi na układ odpornościowy (np. agonisty CD137 lub terapie blokujące punkty kontrolne).
  • Przyjmowanie jakichkolwiek innych leków eksperymentalnych w ciągu ostatnich 28 dni.
  • Przeszłe leczenie wątroby metodami miejscowymi (np. wstrzyknięcia, embolizacja) w ciągu ostatnich 28 dni.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
June 30, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (62)

University of Arizona Cancer Center

Tucson, United States

UC San Diego Moores Cancer Center

La Jolla, United States

University of Southern California-Keck School of Medicine -1975 Zonal Ave

Los Angeles, United States

University of Southern California

Newport Beach, United States

University of California Irvine Medical Center

Orange, United States

California Liver Research Institute

Pasadena, United States

University of California Davis Medical Center

Sacramento, United States

Stanford Health Care

Stanford, United States

Harbor UCLA Medical Center

Torrance, United States

Cedars Sinai Comprehensive Transplant Center

West Hollywood, United States

Rocky Mountain Cancer Centers (Williams) - USOR

Denver, United States

Hartford Healthcare Cancer Institute at Hartford Hospital

Hartford, United States

George Washington University- Medical Faculty Associates

Washington D.C., United States

Washington DC VA Medical Center

Washington D.C., United States

Orlando Health Inc.

Orlando, United States

Northwestern University

Chicago, United States

University of Illinois Health Outpatient Care Center

Chicago, United States

The Duchossois Center for Advanced Medicine

Chicago, United States

University of Kentucky - Markey Cancer Center

Lexington, United States

LSU Health Baton Rouge

Baton Rouge, United States

Our Lady of the Lake Cancer Institute

Baton Rouge, United States

Tufts Medical Center

Boston, United States

Beth Israel Deaconess Medical Center

Boston, United States

Veterans Affairs Ann Arbor Healthcare System

Ann Arbor, United States

Barbara Ann Karmanos Cancer Institute

Detroit, United States

Henry Ford Health System

Detroit, United States

Saint Luke?s Hospital of Kansas City

Kansas City, United States

MorristownMedicalCenter

Morristown, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, United States

Rutgers Cancer Institute of New Jersey at University Hospital

Newark, United States

NYU Langone Hospital - Long Island

Mineola, United States

R.J. Zuckerberg Cancer Hospital/Northwell Health - BRANY - PPDS

New Hyde Park, United States

NYU Langone Medical Center

New York, United States

Icahn School of Medicine at Mount Sinai

New York, United States

Montefiore Medical Center

The Bronx, United States

James J Peters Veterans Administration Medical Center - NAVREF

The Bronx, United States

Levine Cancer Institute

Charlotte, United States

University Hospitals Cleveland Medical Center

Cleveland, United States

Dayton VA Medical Center - NAVREF - PPDS

Dayton, United States

The University of Oklahoma Health Sciences Center

Oklahoma City, United States

Kaiser Permanente Westside Medical Center

Hillsboro, United States

OHSU Knight Cancer Institute Hematology Oncology

Portland, United States

Jefferson Health Honickman Center

Philadelphia, United States

Veterans Affairs Pittsburgh Healthcare System - NAVREF - PPDS

Pittsburgh, United States

The West Clinic (East Campus)

Germantown, United States

Nashville General Hospital at Meharry

Nashville, United States

Liver Institute at Methodist Dallas

Dallas, United States

Moody Outpatient Center ? Parkland Health

Dallas, United States

Texas Oncology (Worth) - USOR

Dallas, United States

University of Texas Southwestern Medical Center

Dallas, United States

Texas Oncology - Denison Cancer Center

Denison, United States

Kelsey Research Foundation

Houston, United States

Michael E Debakey VA Medical Center - NAVREF - PPDS

Houston, United States

Houston Methodist Hospital

Houston, United States

Intermountain Healthcare

Murray, United States

Intermountain Cancer Center

St. George, United States

Inova Schar Cancer Institute

Falls Church, United States

Maryview Hospital, Inc.

Newport News, United States

Bon Secours St. Mary's Hospital

Richmond, United States

VCU Medical Center North Hospital

Richmond, United States

Virginia Mason Medical Center

Seattle, United States

Pan American Center for Oncology Trials, LLC

Rio Piedras, Puerto Rico

Trial contact

Reference Study ID Number: ML44719 https://forpatients.roche.com/

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.