Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Tumor hypoxia is one of the physiological factors for treatment resistance and likely contributes to poor overall survival among patients with head and neck cancer (HNC). Identifying hypoxic features of HNC may allow the personalizing treatment plan. The investigators propose multiparametric Hypoxia MR (HMR) imaging using diffusion, perfusion, and oxygenation as non-invasive, in-vivo imaging components of a hypoxia phenotype. Assessing the hypoxia phenotypes' expression will be critically important for characterizing and predicting CRT response among patients with advanced HNC. A prospective cohort study will be conducted used multiparametric MR (MPMR) imaging correlated with treatment response assessed by 3 months fluorodeoxyglucose-positron emission tomography (FDG-PET). The image analysis approach will be developed to incorporate FDG-PET and quantitative MRI characteristics of tumor (ADC, oxygen-enhanced T1 and T2\* maps, and volume transfer constant (Ktrans) to facilitate 3D visualization of multiparametric information. This proposed study's overarching goal is to develop and validate multiparametric HMR imaging using 18F - (fluoromisonidazole) FMISO-PET and immunohistochemistry (IHC) as the standard of references.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowo rozpoznany rak płasko nabłonkowy głowy i szyi (potwierdzony biopsją lub pobraniem igle)
- •Guz znajdujący się w jamie ustnej, krtani, gardła dolnego, nosogardła lub gardła
- •Pacjent ma być leczony chemioradioterapią lub planowana operacja
- •Zdolność do podpisania świadomej zgody na udział w badaniu
✗ Disqualifies
- •Ciąża
- •Klaustrofobia (lęk przed zamkniętymi przestrzeniami)
- •Rozrusznik serca, stymulator rdzenia kręgowego, implanty uszne lub inne metalowe implanty w ciele
- •Wcześniejsze leczenie raka głowy i szyi (operacja, radioterapia lub chemioterapia)
- •Rak tarczycy, skóry, zatok lub gruczołów ślinowych
- •Poważne problemy z funkcją nerek
- •Niekontrolowana cukrzyca
- •Wykonane wcześniej badanie PET/CT poza naszym ośrodkiem
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
University of Utah
Salt Lake City, United States
Trial contact
Olivia Pratt
Nousheen Alasti
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/6/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.