The goal of this randomized, double-blind, multi-regional phase 3 study of cadonilimab combined with chemotherapy versus chemotherapy in combination with or without nivolumab for the first-line treatment of participants with HER2-negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma trial is to compare OS between cadonilimab combined with chemotherapy and chemotherapy in combination with or without nivolumab in the ITT population.
A Study of TQB2102 for Injection in Patients With Recurrent/Metastatic Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
This trial is no longer recruiting — here are similar active trials
Matched by cancer type/biomarker, currently recruiting.
Metastatic colorectal cancer or mCRC is a cancer that starts in the parts of the large intestine (the colon or rectum) and has already spread to other parts of the body. This cancer can be hard to treat because it can behave differently from one person to another. Over time, treatments may stop working, and side effects can build up. In later treatment stages, there are only a few standard medicine options available. Because of this, studies often look at both how long people live and how treatment affects quality of life. The main aim of this study is to see how long adults in Poland with mCRC live without their cancer getting worse (progression-free survival or PFS) when they receive fruquintinib after at least two previous treatments. Fruquintinib (TAK 113) is a medicine taken by mouth that is designed to slow tumor growth. Other aim is to find out how long adults in Poland with mCRC live while being treated with fruquintinib (overall survival or OS). The study also wants to record how fruquintinib is used in routine care in adults with mCRC in Poland (for example when treatment starts, changes in doses, and how long treatment continues). Another aim is to learn about people with mCRC, such as their medical history and past treatment as well as their quality of life while they are in the study. The study will look at data already existing in the participants' medical charts.
The goal of this clinical trial is to determine the most effective dose of EIK1005 that a person can take safely. Additionally, this study will test how well EIK1005 is tolerated alone and in combination with pembrolizumab in treating patients with advanced cancer.
The purpose of this study is to evaluate the safety and efficacy of Navlimetostat (BMS-986504) monotherapy or in combination with Izalontamab Brengitecan in participants with advanced or metastatic Non-small Cell Lung Cancer (NSCLC) with homozygous MTAP deletion or MTAP loss after progression on prior therapies.
About the trial
TQB2102 is an antibody-drug conjugate comprised of a humanised antibody against Human Epidermal Growth Factor Receptor 2 (HER2), an enzyme-cleavable linker, and a topoisomerase I inhibitor payload, which combine the ability of antibodies to specifically target tumour cells with the highly potent killing activity of drugs with payloads too toxic for systemic administration. This is a Phase 1/Phase 2 study to evaluate the effectiveness, safety, pharmacokinetics (PK) and anti-drug antibody (ADA) of TQB2102 for injection in subjects with HER2-expressing relapsed/metastatic breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent świadomie zgadza się na udział i podpisuje formularz zgody.
- •Wiek od 18 do 75 lat.
- •Rak piersi z obecnością cechy HER2, który powrócił lub dał przerzuty.
- •Stan ogólny pozwalający na udział w badaniu (punktacja ECOG 0-1).
- •Szacowany czas przeżycia co najmniej 3 miesiące.
- •Choroba postępująca lub nietolerancja poprzedniego leczenia.
- •Główne narządy pracują prawidłowo.
- •Kobiety w wieku rozrodczym i mężczyźni muszą stosować skuteczną antykoncepcję podczas badania i 6 miesięcy po jego zakończeniu.
✗ Disqualifies
- •Inny nowotwór zdiagnozowany lub leczony w ciągu ostatnich 3 lat.
- •Nieustępujące poważne skutki uboczne poprzedniego leczenia (poza wypadaniem włosów).
- •Duża operacja, biopsja nacięciowa lub poważny uraz w ciągu ostatnich 28 dni.
- •Nieleczone rany lub złamania.
- •Przebyta choroba płuc wymagająca leczenia sterydami lub podejrzenie takiej choroby.
- •Zakrzepica żył lub tętnic.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- July 8, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (20)
Anhui Pronvincial Cancer Hospital
Hefei, China
Lu'an People's Hospital
Lu'an, China
Cancer Hospital Chinese Academy of Medical Science
Beijing, China
Chongqing University Cancer Hospital
Chongqing, China
Sun Yat-Sen University Cancer Center
Guangzhou, China
Jiangmen Central Hospital
Jiangmen, China
Guangxi Medical University Cancer Hospital
Nanning, China
Harbin Medical University Cancer Hospital
Harbin, China
Hunan Cancer Hospital
Changsha, China
Ganzhou People's Hospital
Ganzhou, China
Jilin Cancer Hospital
Changchun, China
Liaoning Cancer Hospital & Institute
Shenyang, China
The First Hospital of China Medical University
Shenyang, China
Cancer Hospital Affiliated to Shandong First Medical University
Jinan, China
Linyi Cancer Hospital
Linyi, China
The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine
Xi'an, China
Shanxi Cancer Hospital
Taiyuan, China
Suining Central Hospital
Suining, China
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
Zhejiang Cancer Hospital
Hangzhou, China
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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