RecruitingPhase IIEN original

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This pilot trial assesses the effect of the combination of blinatumomab with dasatinib or imatinib and standard chemotherapy for treating patients with Philadelphia chromosome positive (Ph+) or ABL-class Philadelphia chromosome-like (Ph-like) B-Cell acute lymphoblastic leukemia (B-ALL). Blinatumomab is a bispecific antibody that binds to two different proteins-one on the surface of cancer cells and one on the surface of cells in the immune system. An antibody is a protein made by the immune system to help fight infections and other harmful processes/cells/molecules. Blinatumomab may bind to the cancer cell and a T cell (which plays a key role in the immune system's fighting response) at the same time. Blinatumomab may strengthen the immune system's ability to fight cancer cells by activating the body's own immune cells to destroy the tumor. Dasatinib and imatinib are in a class of medications called tyrosine kinase inhibitors. They work by blocking the action of an abnormal protein that signals cancer cells to multiply, which may help keep cancer cells from growing. Giving blinatumomab and dasatinib or imatinib in combination with standard chemotherapy may work better in treating patients with Ph+ or Ph-like ABL-class B-ALL than dasatinib or imatinib with chemotherapy.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Pacjent musi mieć od 1 do 45 lat (w zależności od centrum badawczego) w momencie rozpoczęcia badania.
  • Nowo zdiagnozowana ostra białaczka limfoblastyczna typu B (B-ALL) z określonymi mutacjami genetycznymi (Ph+ lub ABL-class Ph-like).
  • Badanie musi potwierdzić obecność tych mutacji przed rozpoczęciem leczenia.
  • Pacjenci z mutacją Ph+ B-ALL musieli rozpocząć leczenie początkowe (indukcja), ale nie dłużej niż 14 dni.
  • Pacjenci z mutacją ABL-class Ph-like B-ALL musieli ukończyć 4-5 tygodni leczenia początkowego.
  • Pacjenci mogli rozpocząć przyjmowanie leków dasatinib lub imatinib, ale nie dłużej niż przez 14 dni (dla Ph+) lub 35 dni (dla ABL-class Ph-like).

Simplified criteria — AI translation

Trial details

Minimum age
366 Days
Maximum age
46 Years
Last updated (source)
July 2, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (153)

Children's Hospital of Alabama

Birmingham, United States

Phoenix Childrens Hospital

Phoenix, United States

Banner University Medical Center - Tucson

Tucson, United States

Arkansas Children's Hospital

Little Rock, United States

Kaiser Permanente Downey Medical Center

Downey, United States

Loma Linda University Medical Center

Loma Linda, United States

Miller Children's and Women's Hospital Long Beach

Long Beach, United States

Children's Hospital Los Angeles

Los Angeles, United States

Valley Children's Hospital

Madera, United States

UCSF Benioff Children's Hospital Oakland

Oakland, United States

Kaiser Permanente-Oakland

Oakland, United States

Children's Hospital of Orange County

Orange, United States

Lucile Packard Children's Hospital Stanford University

Palo Alto, United States

University of California Davis Comprehensive Cancer Center

Sacramento, United States

Rady Children's Hospital - San Diego

San Diego, United States

UCSF Medical Center-Mission Bay

San Francisco, United States

Children's Hospital Colorado

Aurora, United States

Connecticut Children's Medical Center

Hartford, United States

Yale University

New Haven, United States

Alfred I duPont Hospital for Children

Wilmington, United States

MedStar Georgetown University Hospital

Washington D.C., United States

Children's National Medical Center

Washington D.C., United States

Golisano Children's Hospital of Southwest Florida

Fort Myers, United States

UF Health Cancer Institute - Gainesville

Gainesville, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, United States

Nemours Children's Clinic-Jacksonville

Jacksonville, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, United States

Arnold Palmer Hospital for Children

Orlando, United States

Nemours Children's Hospital

Orlando, United States

Nemours Children's Clinic - Pensacola

Pensacola, United States

Johns Hopkins All Children's Hospital

St. Petersburg, United States

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, United States

Saint Mary's Medical Center

West Palm Beach, United States

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, United States

Augusta University Medical Center

Augusta, United States

Atrium Health Navicent

Macon, United States

Memorial Health University Medical Center

Savannah, United States

Kapiolani Medical Center for Women and Children

Honolulu, United States

Saint Luke's Cancer Institute - Boise

Boise, United States

Lurie Children's Hospital-Chicago

Chicago, United States

University of Illinois

Chicago, United States

University of Chicago Comprehensive Cancer Center

Chicago, United States

Advocate Children's Hospital-Oak Lawn

Oak Lawn, United States

Advocate Children's Hospital-Park Ridge

Park Ridge, United States

OSF Children's Hospital of Illinois

Peoria, United States

Southern Illinois University School of Medicine

Springfield, United States

Riley Hospital for Children

Indianapolis, United States

Blank Children's Hospital

Des Moines, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

Norton Children's Hospital

Louisville, United States

Children's Hospital New Orleans

New Orleans, United States

Ochsner Medical Center Jefferson

New Orleans, United States

Maine Children's Cancer Program

Scarborough, United States

Sinai Hospital of Baltimore

Baltimore, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, United States

Walter Reed National Military Medical Center

Bethesda, United States

Dana-Farber Cancer Institute

Boston, United States

UMass Memorial Medical Center - University Campus

Worcester, United States

C S Mott Children's Hospital

Ann Arbor, United States

Children's Hospital of Michigan

Detroit, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, United States

Bronson Methodist Hospital

Kalamazoo, United States

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, United States

University of Minnesota/Masonic Cancer Center

Minneapolis, United States

Mayo Clinic in Rochester

Rochester, United States

University of Mississippi Medical Center

Jackson, United States

Children's Mercy Hospitals and Clinics

Kansas City, United States

Washington University School of Medicine

St Louis, United States

Children's Hospital and Medical Center of Omaha

Omaha, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Hackensack University Medical Center

Hackensack, United States

Morristown Medical Center

Morristown, United States

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, United States

Saint Joseph's Regional Medical Center

Paterson, United States

Presbyterian Hospital

Albuquerque, United States

University of New Mexico Cancer Center

Albuquerque, United States

Albany Medical Center

Albany, United States

Roswell Park Cancer Institute

Buffalo, United States

NYU Langone Hospital - Long Island

Mineola, United States

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, United States

Memorial Sloan Kettering Cancer Center

New York, United States

NYP/Weill Cornell Medical Center

New York, United States

Stony Brook University Medical Center

Stony Brook, United States

State University of New York Upstate Medical University

Syracuse, United States

Montefiore Medical Center - Moses Campus

The Bronx, United States

New York Medical College

Valhalla, United States

Mission Hospital

Asheville, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, United States

Duke University Medical Center

Durham, United States

Wake Forest University Health Sciences

Winston-Salem, United States

Sanford Broadway Medical Center

Fargo, United States

Children's Hospital Medical Center of Akron

Akron, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, United States

Rainbow Babies and Childrens Hospital

Cleveland, United States

Nationwide Children's Hospital

Columbus, United States

Dayton Children's Hospital

Dayton, United States

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, United States

Penn State Children's Hospital

Hershey, United States

Children's Hospital of Philadelphia

Philadelphia, United States

Saint Christopher's Hospital for Children

Philadelphia, United States

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, United States

Rhode Island Hospital

Providence, United States

Prisma Health Richland Hospital

Columbia, United States

BI-LO Charities Children's Cancer Center

Greenville, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, United States

East Tennessee Childrens Hospital

Knoxville, United States

The Children's Hospital at TriStar Centennial

Nashville, United States

Vanderbilt University/Ingram Cancer Center

Nashville, United States

Dell Children's Medical Center of Central Texas

Austin, United States

Driscoll Children's Hospital

Corpus Christi, United States

Medical City Dallas Hospital

Dallas, United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, United States

El Paso Children's Hospital

El Paso, United States

Cook Children's Medical Center

Fort Worth, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, United States

Covenant Children's Hospital

Lubbock, United States

UMC Cancer Center / UMC Health System

Lubbock, United States

Children's Hospital of San Antonio

San Antonio, United States

Methodist Children's Hospital of South Texas

San Antonio, United States

University of Texas Health Science Center at San Antonio

San Antonio, United States

Primary Children's Hospital

Salt Lake City, United States

University of Vermont and State Agricultural College

Burlington, United States

University of Virginia Cancer Center

Charlottesville, United States

Inova Fairfax Hospital

Falls Church, United States

Children's Hospital of The King's Daughters

Norfolk, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

Carilion Children's

Roanoke, United States

Seattle Children's Hospital

Seattle, United States

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, United States

Mary Bridge Children's Hospital and Health Center

Tacoma, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Children's Hospital of Wisconsin

Milwaukee, United States

Queensland Children's Hospital

South Brisbane, Australia

Perth Children's Hospital

Perth, Australia

Alberta Children's Hospital

Calgary, Canada

British Columbia Children's Hospital

Vancouver, Canada

CancerCare Manitoba

Winnipeg, Canada

IWK Health Centre

Halifax, Canada

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Canada

Hospital for Sick Children

Toronto, Canada

The Montreal Children's Hospital of the MUHC

Montreal, Canada

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Canada

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, Canada

University Pediatric Hospital

San Juan, Puerto Rico

Trial contact

Matthew A. Kutny

PRINCIPAL_INVESTIGATOR

Site Public Contact

Dana B. Salzberg

PRINCIPAL_INVESTIGATOR

Site Public Contact

Monica M. Davini

PRINCIPAL_INVESTIGATOR

Site Public Contact

Michael W. Bishop

PRINCIPAL_INVESTIGATOR

Site Public Contact

Robert M. Cooper

PRINCIPAL_INVESTIGATOR

Site Public Contact

Albert Kheradpour

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jacqueline N. Casillas

PRINCIPAL_INVESTIGATOR

Site Public Contact

Andrew Doan

PRINCIPAL_INVESTIGATOR

Ruetima Titapiwatanakun

PRINCIPAL_INVESTIGATOR

Karen R. Rabin

PRINCIPAL_INVESTIGATOR

Site Public Contact

Aarati V. Rao

PRINCIPAL_INVESTIGATOR

Elyssa M. Rubin

PRINCIPAL_INVESTIGATOR

Jay Michael S. Balagtas

PRINCIPAL_INVESTIGATOR

Site Public Contact

Marcio H. Malogolowkin

PRINCIPAL_INVESTIGATOR

Site Public Contact

William D. Roberts

PRINCIPAL_INVESTIGATOR

Kelly W. Maloney

PRINCIPAL_INVESTIGATOR

Site Public Contact

Michael S. Isakoff

PRINCIPAL_INVESTIGATOR

Farzana Pashankar

PRINCIPAL_INVESTIGATOR

Emi H. Caywood

PRINCIPAL_INVESTIGATOR

Site Public Contact

Caileigh Pudela

PRINCIPAL_INVESTIGATOR

Jeffrey S. Dome

PRINCIPAL_INVESTIGATOR

Emad K. Salman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Brian Stover

PRINCIPAL_INVESTIGATOR

Site Public Contact

Iftikhar Hanif

PRINCIPAL_INVESTIGATOR

Site Public Contact

Julio C. Barredo

PRINCIPAL_INVESTIGATOR

Jaime M. Libes-Bander

PRINCIPAL_INVESTIGATOR

Jeffrey H. Schwartz

PRINCIPAL_INVESTIGATOR

Jennifer B. Dean

PRINCIPAL_INVESTIGATOR

Don E. Eslin

PRINCIPAL_INVESTIGATOR

Site Public Contact

Matthew D. Ramirez

PRINCIPAL_INVESTIGATOR

Lauren Raney

PRINCIPAL_INVESTIGATOR

Colleen H. McDonough

PRINCIPAL_INVESTIGATOR

Sushmita Nair

PRINCIPAL_INVESTIGATOR

Andrew L. Pendleton

PRINCIPAL_INVESTIGATOR

Site Public Contact

Wade T. Kyono

PRINCIPAL_INVESTIGATOR

Martha M. Pacheco

PRINCIPAL_INVESTIGATOR

Site Public Contact

Loretta S. Li

PRINCIPAL_INVESTIGATOR

Site Public Contact

Dipti S. Dighe

PRINCIPAL_INVESTIGATOR

Gabrielle Lapping-Carr

PRINCIPAL_INVESTIGATOR

Site Public Contact

Rebecca E. McFall

PRINCIPAL_INVESTIGATOR

Prerna Kumar

PRINCIPAL_INVESTIGATOR

Site Public Contact

Gregory P. Brandt

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sandeep Batra

PRINCIPAL_INVESTIGATOR

Samantha L. Mallory

PRINCIPAL_INVESTIGATOR

Site Public Contact

Andrew P. Groves

PRINCIPAL_INVESTIGATOR

Site Public Contact

James T. Badgett

PRINCIPAL_INVESTIGATOR

Michael J. Ferguson

PRINCIPAL_INVESTIGATOR

Site Public Contact

Maria C. Velez-Yanguas

PRINCIPAL_INVESTIGATOR

Craig Lotterman

PRINCIPAL_INVESTIGATOR

Eric C. Larsen

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jason M. Fixler

PRINCIPAL_INVESTIGATOR

Site Public Contact

Stacy L. Cooper

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kip R. Hartman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Melissa A. Burns

PRINCIPAL_INVESTIGATOR

Stefanie R. Lowas

PRINCIPAL_INVESTIGATOR

Site Public Contact

Joshua W. Goldman

PRINCIPAL_INVESTIGATOR

Meret Henry

PRINCIPAL_INVESTIGATOR

Kathleen Y. Butler

PRINCIPAL_INVESTIGATOR

Michael K. Richards

PRINCIPAL_INVESTIGATOR

Site Public Contact

Peter M. Gordon

PRINCIPAL_INVESTIGATOR

Site Public Contact

Madeleine O'Keefe

PRINCIPAL_INVESTIGATOR

Site Public Contact

Amanda Strobel

PRINCIPAL_INVESTIGATOR

Keith J. August

PRINCIPAL_INVESTIGATOR

Laura G. Schuettpelz

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jill C. Beck

PRINCIPAL_INVESTIGATOR

Alan K. Ikeda

PRINCIPAL_INVESTIGATOR

Angela Ricci

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jing Chen

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kathryn L. Laurie

PRINCIPAL_INVESTIGATOR

Site Public Contact

Marissa Botwinick

PRINCIPAL_INVESTIGATOR

Site Public Contact

Alissa Kahn

PRINCIPAL_INVESTIGATOR

Site Public Contact

Beeling Armijo

PRINCIPAL_INVESTIGATOR

Jessica M. Valdez

PRINCIPAL_INVESTIGATOR

Site Public Contact

Lauren R. Weintraub

PRINCIPAL_INVESTIGATOR

Lisa Niswander

PRINCIPAL_INVESTIGATOR

Chana L. Glasser

PRINCIPAL_INVESTIGATOR

Site Public Contact

Hiren Patel

PRINCIPAL_INVESTIGATOR

Site Public Contact

Elizabeth A. Raetz

PRINCIPAL_INVESTIGATOR

Lewis B. Silverman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kavitha Ramaswamy

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jaclyn Rosenzweig

PRINCIPAL_INVESTIGATOR

Site Public Contact

Laura E. Hogan

PRINCIPAL_INVESTIGATOR

Site Public Contact

Melanie A. Comito

PRINCIPAL_INVESTIGATOR

Alice Lee

PRINCIPAL_INVESTIGATOR

Site Public Contact

Andrew J. Bellantoni

PRINCIPAL_INVESTIGATOR

Douglas J. Scothorn

PRINCIPAL_INVESTIGATOR

Thomas B. Alexander

PRINCIPAL_INVESTIGATOR

Site Public Contact

Joel A. Kaplan

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jessica M. Sun

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sarah Supples

PRINCIPAL_INVESTIGATOR

Samuel J. Milanovich

PRINCIPAL_INVESTIGATOR

Site Public Contact

Erin Wright

PRINCIPAL_INVESTIGATOR

Site Public Contact

Erin H. Breese

PRINCIPAL_INVESTIGATOR

Site Public Contact

Duncan S. Stearns

PRINCIPAL_INVESTIGATOR

Mark A. Ranalli

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jordan M. Wright

PRINCIPAL_INVESTIGATOR

Jamie L. Dargart

PRINCIPAL_INVESTIGATOR

Rene Y. McNall-Knapp

PRINCIPAL_INVESTIGATOR

Jacob A. Troutman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Lisa M. McGregor

PRINCIPAL_INVESTIGATOR

Sarah K. Tasian

PRINCIPAL_INVESTIGATOR

Site Public Contact

Gregory E. Halligan

PRINCIPAL_INVESTIGATOR

Colleen Mathews

PRINCIPAL_INVESTIGATOR

Site Public Contact

Bradley DeNardo

PRINCIPAL_INVESTIGATOR

Stuart L. Cramer

PRINCIPAL_INVESTIGATOR

Aniket Saha

PRINCIPAL_INVESTIGATOR

Kayelyn J. Wagner

PRINCIPAL_INVESTIGATOR

Site Public Contact

Susan E. Spiller

PRINCIPAL_INVESTIGATOR

Site Public Contact

Clinton M. Carroll

PRINCIPAL_INVESTIGATOR

Site Public Contact

Brianna N. Smith

PRINCIPAL_INVESTIGATOR

Shannon M. Cohn

PRINCIPAL_INVESTIGATOR

Nkechi I. Mba

PRINCIPAL_INVESTIGATOR

Site Public Contact

Maurizio L. Ghisoli

PRINCIPAL_INVESTIGATOR

Tamra L. Slone

PRINCIPAL_INVESTIGATOR

Benjamin Carcamo

PRINCIPAL_INVESTIGATOR

Kenneth M. Heym

PRINCIPAL_INVESTIGATOR

Site Public Contact

Chelsea Vrana

PRINCIPAL_INVESTIGATOR

Kishor M. Bhende

PRINCIPAL_INVESTIGATOR

Site Public Contact

Erin K. Barr

PRINCIPAL_INVESTIGATOR

Julie Voeller

PRINCIPAL_INVESTIGATOR

Jose M. Esquilin

PRINCIPAL_INVESTIGATOR

Anne-Marie R. Langevin

PRINCIPAL_INVESTIGATOR

Site Public Contact

Luke D. Maese

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jessica L. Heath

PRINCIPAL_INVESTIGATOR

Brian C. Belyea

PRINCIPAL_INVESTIGATOR

Robin Y. Dulman

PRINCIPAL_INVESTIGATOR

Melissa S. Mark

PRINCIPAL_INVESTIGATOR

Jordyn R. Griffin

PRINCIPAL_INVESTIGATOR

Erwood G. Edwards

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sarah E. Leary

PRINCIPAL_INVESTIGATOR

Judy L. Felgenhauer

PRINCIPAL_INVESTIGATOR

Robert G. Irwin

PRINCIPAL_INVESTIGATOR

Catherine A. Long

PRINCIPAL_INVESTIGATOR

Cathy A. Lee-Miller

PRINCIPAL_INVESTIGATOR

Site Public Contact

Paul D. Harker-Murray

PRINCIPAL_INVESTIGATOR

Site Public Contact

Christopher J. Fraser

PRINCIPAL_INVESTIGATOR

Michelle Ng

PRINCIPAL_INVESTIGATOR

Victor A. Lewis

PRINCIPAL_INVESTIGATOR

Stephanie M. Villeneuve

PRINCIPAL_INVESTIGATOR

Chelsea Ash

PRINCIPAL_INVESTIGATOR

Site Public Contact

Uma H. Athale

PRINCIPAL_INVESTIGATOR

Angela S. Punnett

PRINCIPAL_INVESTIGATOR

Stephanie Mourad

PRINCIPAL_INVESTIGATOR

Monia Marzouki

PRINCIPAL_INVESTIGATOR

Josee Brossard

PRINCIPAL_INVESTIGATOR

Bruno Michon

PRINCIPAL_INVESTIGATOR

Site Public Contact

Maria E. Echevarria

PRINCIPAL_INVESTIGATOR

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.