AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase 1/2, global multicentre, open-label, single-arm, dose escalation and dose optimization study of surovatamig (AZD0486) to evaluate the safety, tolerability, and efficacy of surovatamig (AZD0486) monotherapy in participants with R/R B ALL. The study will consist of 4 parts. Part A: monotherapy dose escalation in 3L+ B-ALL. Part B: dose optimization in 3L+ B-ALL. Part C: Dose expansion in 3L+ B-ALL. Part D: Dose optimization and efficacy expansion in R/R B-ALL (2L+)
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 12 lat i starszy
- •Zdiagnozowana białaczka limfoblastyczna typu B z białkami CD19
- •Wcześniej leczona co najmniej 2 rodzajami terapii albo 1 rodzajem, jeśli nie było innej opcji
- •Sprawność fizyczna: dorośli (powyżej 16 lat) mogą mieć ograniczenia w aktywnościach, dzieci młodsze powinny zachować co najmniej 50% zdolności do aktywności
✗ Disqualifies
- •Białaczka rozprzestrzeniła się do mózgu lub płynu mózgowo-rdzeniowego
- •Przerzuty choroby w innych narządach poza szpikom
- •Historia innych chorób mózgu (epilepsja, udar, demencja, zaburzenia psychiczne)
- •Ciężkie działania niepożądane ze wcześniejszego leczenia (stopień 4 lub wyższy)
- •Poprzednie leczenie nowoczesnymi terapiami w ciągu ostatnich 3-12 tygodni
- •Historia innych nowotworów
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Last updated (source)
- August 19, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (82)
Research Site
Birmingham, United States
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Duarte, United States
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Los Angeles, United States
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Palo Alto, United States
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Tampa, United States
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Atlanta, United States
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Chicago, United States
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New York, United States
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Houston, United States
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Richmond, United States
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Seattle, United States
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Milwaukee, United States
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Melbourne, Australia
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Porto Alegre, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Toronto, Canada
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Montreal, Canada
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Montreal, Canada
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Changsha, China
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Chengdu, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Nanjing, China
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Nanjing, China
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Suzhou, China
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Tianjin, China
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Zhengzhou, China
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Caen, France
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Marseille, France
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Nantes, France
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Paris, France
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Pierre-Bénite, France
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Toulouse, France
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Berlin, Germany
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Cologne, Germany
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Düsseldorf, Germany
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Essen, Germany
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Frankfurt, Germany
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Freiburg im Breisgau, Germany
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Halle, Germany
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Hamburg, Germany
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Kiel, Germany
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München, Germany
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Münster, Germany
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Würzburg, Germany
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Bergamo, Italy
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Bologna, Italy
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Monza, Italy
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Naples, Italy
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Roma, Italy
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Bunkyō City, Japan
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Chiba, Japan
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Chūōku, Japan
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Fukuoka, Japan
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Kashiwa, Japan
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Kyoto, Japan
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Okayama, Japan
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Osaka, Japan
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Sapporo, Japan
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Toyohashi, Japan
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Yamagata, Japan
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Salamanca, Spain
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Valencia, Spain
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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London, United Kingdom
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Manchester, United Kingdom
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Surrey, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/20/2026.
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