Study of Olutasidenib and Temozolomide in HGG
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this study is to determine the efficacy of the study drug olutasidenib to treat newly diagnosed pediatric and young adult patients with a high-grade glioma (HGG) harboring an IDH1 mutation. The main question the study aims to answer is whether the combination of olutasidenib and temozolomide (TMZ) can prolong the life of patients diagnosed with an IDH-mutant HGG.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek od 12 do 39 lat
- •Nowo rozpoznany glejak wysoki stopień z mutacją IDH1
- •Potwierdzony nowotwór mózgu lub rdzenia kręgowego poprzez badanie tkanki (biopsja lub operacja)
- •Jeden z wymaganych typów mutacji IDH1: R132H, R132C, R132S, R132G lub R132L
- •Brak przerzutów do innych części ciała
✗ Disqualifies
- •Mutacja genu IDH2 zamiast IDH1
- •Oligodendroglioma z mutacją IDH i delecją 1p/19q
- •Przerzuty nowotworu do innych organów
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Maximum age
- 39 Years
- Last updated (source)
- September 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (20)
Children's Hospital Colorado
Aurora, United States
Children's National Medical Center
Washington D.C., United States
University of Miami Hospital and Clinics
Miami, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, United States
Susan Chi
Boston, United States
Duke University Health System
Durham, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
Nationwide Children's Hospital
Columbus, United States
Children's Hospital of Philadelphia
Philadelphia, United States
Texas Children's Hospital
Houston, United States
Seattle Children's Hospital
Seattle, United States
Sydney Children's Hospital
Randwick, Australia
Queensland Children's Hospital
South Brisbane, Australia
Perth Children's Hospital
Perth, Australia
The Hospital for Sick Children (SickKids)
Toronto, Canada
Montreal Children's Hospital
Montreal, Canada
Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
Heidelberg, Germany
Princess Máxima Center
Utrecht, Netherlands
Starship Children's Hospital
Auckland, New Zealand
Great Ormond Street Hospital
London, United Kingdom
Trial contact
Kay Patel
Vanessa Tan
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/2/2026.
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