A Study of the Gut Microbiome in Hormone Receptor-positive HER2-negative Breast Cancer Treated With CDK4/6 Inhibitors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Ciclibiome is a prospective study including BC patients starting treatment with a CDK4/6 inhibitor (in the metastatic and in the adjuvant setting). This study will focus on the interplay between the gut microbiome (its composition and evolution during treatment), circulating immune, metabolic and cytokine biomarkers (before and during treatment), and response outcomes to the CDK4/6 inhibitor. The main aim of the study is to highlight the existence of a microbial, immune and/or metabolic biomarker of response to CDK4/6 inhibition in BC, assessable by a stool or blood sample examination. Ultimately, this will allow to study new potential combination partners for CDK4/6 inhibitors in escalation trials for poor prognosis patients.
Original English text from ClinicalTrials.gov
Eligibility criteria
Włączenie: Rак piersi na zaawansowanym etapie, pierwszy raz leczony, wiek 18+, zgoda pacjenta, dostępne tkanki guza. Wykluczenie: Już rozpoczęty inhibitor CDK4/6, inny rak w ciągu 3 lat, antybiotyki w ciągu miesiąca, HIV lub HCV, aktywne zapalenie wątroby, immunosupresja.
Simplified criteria
Trial details
- Minimum age
- 18 Years
- Maximum age
- 100 Years
- Last updated (source)
- January 10, 2025
- Sex
- No restrictions
Locations (3)
Institut Jules Bordet
Brussels, Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium
CHU UCL Namur
Namur, Belgium
Trial contact
Cédric Van Marcke, MD, PhD
Elodie Villar
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.