A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma \[cutaneous/acral\], squamous cell carcinomas of the head and neck (SCCHN), HER2-negative gastric cancer ovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, prostate cancer, second-line gastric cancer, lung cancer, and breast cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wyrażenie świadomej zgody na udział w badaniu.
- •Osoby w wieku 18 lat lub starsze.
- •Posiadanie zaawansowanej lub przerzutowej choroby nowotworowej (której nie da się wyleczyć operacyjnie ani radioterapią).
- •W przypadku czerniaka: potwierdzony histologicznie lub cytologicznie czerniak skóry, który postępował mimo leczenia anty-PD-1/PD-L1.
- •W przypadku czerniaka: jeśli jest to czerniak z mutacją BRAF, musiał też postępować mimo leczenia inhibitorami BRAF/MEK.
- •W przypadku raków głowy i szyi: potwierdzony rak płaskonabłonkowy (w określonych lokalizacjach), który postępował po leczeniu systemowym (co najmniej 1, ale mniej niż 3 linie leczenia).
✗ Disqualifies
- •Brak danych o kryteriach wykluczenia w dostarczonym tekście.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- May 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (85)
City of Hope
Duarte, United States
Yale Cancer Center
New Haven, United States
AdventHealth Medical Group Oncology Research at Celebration
Kissimmee, United States
University of Illinois Cancer Center
Chicago, United States
Johns Hopkins University
Baltimore, United States
Health Partners Frauenshuh Cancer Center
Saint Louis Park, United States
Health Partners Cancer Center at Regions Hospital
Saint Paul, United States
Washington University, School of Medicine
St Louis, United States
Roswell Park Cancer Institute IDS
Buffalo, United States
Memorial Sloan Kettering Hospital
New York, United States
SCRI Oncology Partners
Nashville, United States
The University of Texas MD Anderson Cancer Center
Houston, United States
Fred Hutchinson Cancer Center
Seattle, United States
Chris O'Brien Lifehouse
Camperdown, Australia
Icon Cancer Centre Chermside
Chermside, Australia
Monash Medical Centre Clayton
Clayton, Australia
Icon Cancer Centre Hobart
Hobart, Australia
Icon Cancer Centre Townsville
Hyde Park, Australia
Cliniques Universitaires Saint-Luc
Brussels, Belgium
UZA
Edegem, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
Universitair Ziekenhuis Brussel
Jette, Belgium
UZ Leuven
Leuven, Belgium
Cross Cancer Institute
Edmonton, Canada
Sunnybrook Research Institute
Toronto, Canada
Princess Margaret Cancer Centre
Toronto, Canada
BC Cancer - Vancouver
Vancouver, Canada
West China Hospital, Sichuan University
Chengdu, China
Sun Yat-sen University Cancer Center
Guangzhou, China
Chu Bordeaux
Bordeaux, France
Centre Georges Franăois Leclerc
Dijon, France
Hopital Claude Huriez - Chu Lille
Lille, France
Centre Léon Bérard
Lyon, France
Hăpital de La Timone
Marseille, France
Chu Nantes - Hătel Dieu
Nantes, France
Institut Claudius Regaud
Toulouse, France
ICL - Alexis Vautrin
Vandœuvre-lès-Nancy, France
Institut Gustave Roussy
Villejuif, France
Krankenhaus Nordwest GmbH
Frankfurt, Germany
Bacs-Kiskun Varmegyei Oktatokorhaz
Kecskemét, Hungary
Humanitas Gavazzeni
Bergamo, Italy
IRCCS Ospedale Policlinico San Martino
Genova, Italy
AOU Federico II - Oncologia Clinica
Naples, Italy
Centro Ricerche Cliniche di Verona s.r.l.
Verona, Italy
Saitama Medical University International Medical Center
Hidaka, Japan
National Cancer Center Hospital East
Kashiwa-shi, Japan
NHO Shikoku Cancer Center
Matsuyama, Japan
Shizuoka Cancer Center
Nagaizumi-cho, Japan
Aichi Cancer Center Hospital
Nagoya, Japan
Kindai University Hospital
Osakasayama-shi, Japan
National Cancer Center Hospital
Tokyo, Japan
Cancer Institute Hospital of JFCR
Tokyo, Japan
Yokohama City University Medical Center
Yokohama, Japan
Amsterdam UMC locatie Vumc
Amsterdam, Netherlands
Universitair Medisch Centrum Groningen
Groningen, Netherlands
Leids Universitair Medisch Centrum
Leiden, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Radboud University Medical Center
Nijmegen, Netherlands
Akershus universitetssykehus
Lørenskog, Norway
Haukeland universitetssjukehus
Lørenskog, Norway
Oslo Universitetssykehus HF, Radiumhospitalet
Oslo, Norway
Cha Bundang Medical Center, Cha University
Seongnam, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital Universitari Vall D'Hebron
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital de La Santa Creu I Sant Pau
Barcelona, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Universitario Ramon Y Cajal
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
HOSPITAL REGIONAL UNIVERSITARIO de MALAGA AVDA.
Málaga, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Chang Gung Memorial Hospital
Taoyuan, Taiwan
University Hospital Coventry
Coventry, United Kingdom
Barts Hospital
London, United Kingdom
Royal Free Hospital
London, United Kingdom
Nottingham City Hospital Campus
Nottingham, United Kingdom
Trial contact
Daiichi Sankyo Contact for Clinical Trial Information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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