PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Eligible patients with stage 2 and 3 triple negative breast cancer will be treated with 4 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab. A PET scan will be performed at baseline and after 1 cycle of therapy. A breast MRI will be performed after treatment completion. Patients with complete clinical response will proceed to surgery. Patients with clinical residual disease will complete neoadjuvant rescue with 4 cycles of doxorubicin/cyclophosphamide prior to surgery. If residual disease identified after surgery, adjuvant therapy to be determined by the treating oncologist (may include doxorubicin/cyclophosphamide/pembrolizumab, capecitabine etc).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak piersi stadium II-III bez receptorów hormonalnych (ER i PR do 10%)
- •Wiek co najmniej 18 lat
- •Dobry ogólny stan zdrowia (skala ECOG 0-2)
- •Zdolność do chemioterapii i immunoterapii (w ocenie lekarza)
- •Prawidłowe funkcje narządów wewnętrznych i szpiku kostnego
- •Brak niekontrolowanych chorób autoimmunologicznych
- •Umiejętność zrozumienia i podpisania świadomej zgody
✗ Disqualifies
- •Niemożliwość wykonania badania PET lub MRI
- •Przerzuty nowotworu lub nawrót choroby
- •Rak zapalno-wysiękowy piersi
- •Poprzednia terapia paclitakselem, karboplatyną lub inhibitorami kontrolnych punktów immunologicznych
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 23, 2025
- Sex
- Female only
Therapies / drugs in trial
Locations (2)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, United States
Trial contact
Cesar A Santa-Maria, MD
Hopkins Breast Trials
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.