VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 12 lat lub więcej
- •Potwierdzona diagnoza czerniaka skóry, który nie może być całkowicie usunięty chirurgicznie lub rozprzestrzenił się na inne części ciała (stadium IIIb-IV)
- •Choroba postępowała podczas leczenia dwoma rodzajami leków immunologicznych (anti-PD-1 i anti-CTLA-4)
- •Wcześniejsze leczenie anti-PD-1 trwało co najmniej 8 tygodni
- •Postęp choroby potwierdzony badaniami kontrolnymi w odstępie 4 tygodni
- •Pacjenci, którzy nie mogą otrzymywać leków anti-CTLA-4 z powodu innych schorzeń lub wcześniejszych efektów ubocznych, mogą uczestniczyć jeśli choroba postępuje na leczeniu anti-PD-1
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Years
- Last updated (source)
- July 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (81)
Banner MD Anderson Cancer Center
Gilbert, United States
UC San Diego Moores Cancer Center
La Jolla, United States
The Angeles Clinic and Research Institute
Los Angeles, United States
USC Norris Comprehensive Cancer Center
Los Angeles, United States
UCLA Department of Medicine - Hematology/Oncology
Los Angeles, United States
UC Irvine Health, Chao Family Comprehensive Cancer Center
Orange, United States
Stanford Cancer Institute
Palo Alto, United States
Sutter Medical Group
Sacramento, United States
San Francisco Oncology Associates
San Francisco, United States
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, United States
University of Colorado Hospital - Anschutz Cancer Pavilion
Aurora, United States
The Melanoma and Skin Cancer Institute
Englewood, United States
MedStar Washington Hospital Center
Washington D.C., United States
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, United States
Baptist MD Anderson Cancer Center
Jacksonville, United States
Moffitt Cancer Center
Tampa, United States
Winship Cancer Institute, Emory University
Atlanta, United States
Northwestern Memorial Hospital
Chicago, United States
Advocate Lutheran General Hospital
Park Ridge, United States
University of Iowa
Iowa City, United States
University of Kansas Cancer Center
Westwood, United States
University of Louisville Brown Cancer Center
Louisville, United States
Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)
Detroit, United States
Corewell Health
Grand Rapids, United States
University of Minnesota
Minneapolis, United States
Dartmouth Hitchcock Cancer Center
Lebanon, United States
MD Anderson Cancer Center at Cooper
Camden, United States
Hackensack University Medical Center
Hackensack, United States
Morristown Medical Center - Atlantic Health System
Morristown, United States
Roswell Park Cancer Institute
Buffalo, United States
Northwell Health, R.J. Zuckerberg Cancer Center
Lake Success, United States
Stony Brook University Cancer Center
Stony Brook, United States
Montefiore Medical Center
The Bronx, United States
University of North Carolina at Chapel Hill
Chapel Hill, United States
Duke Cancer Center
Durham, United States
The Ohio State University- Martha Morehouse Tower
Columbus, United States
Thomas Jefferson University
Philadelphia, United States
Fox Chase Cancer Center
Philadelphia, United States
UPMC
Pittsburgh, United States
Rhode Island Hospital
Providence, United States
West Cancer Center and Research Institute
Germantown, United States
University of Tennessee
Knoxville, United States
Texas Oncology
Dallas, United States
University of Texas Southwestern Medical Center
Dallas, United States
The University of Texas MD Anderson Cancer Center
Houston, United States
Intermountain Health
Murray, United States
Huntsman Cancer Institute
Salt Lake City, United States
St. George Regional Hospital
St. George, United States
University of Vermont Medical Center
Burlington, United States
West Virginia University
Morgantown, United States
CHU de Bordeaux, Hôpital Saint-André
Bordeaux, France
CHU de Lille
Lille, France
Hopital de La Timone
Marseille, France
CHU Nice
Nice, France
Hôpital Saint Louis - AP-HP
Paris, France
Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud
Pierre-Bénite, France
Institut Gustave Roussy
Villejuif, France
Charité - Universitätsmedizin Berlin
Berlin, Germany
University Hospital Carl Gustav Carus Dresden
Dresden, Germany
Helios Klinik
Erfurt, Germany
Universitätsklinikum Essen
Essen, Germany
Universitätsklinikum Medical Center
Hamburg, Germany
Universitätsklinikum Hospital Heidelberg
Heidelberg, Germany
University of Kiel
Kiel, Germany
Universitatsklinikum Mainz Hautklinik und Poliklinik
Mainz, Germany
LMU München - Klinik and Poliklinik für Dermatologie und Allergologie, Dermatoonkologie
München, Germany
Universitätsklinikum of Tübingen
Tübingen, Germany
National and Kapodistrian University of Athens, General Hospital of Athens "Laiko"
Athens, Greece
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Maria Sklodowska-Curie National Research Institute of Oncology
Warsaw, Poland
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Spain
Clinica Universidad de Navarra - Madrid
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Clinica Universidad de Navarra - Pamplona
Pamplona, Spain
Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, United Kingdom
Royal Free London NHS Foundation Trust - Royal Free Hospital
London, United Kingdom
Guy's & St. Thomas' NHS Foundation Trust
London, United Kingdom
The Royal Marsden NHS Foundation Trust
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Trial contact
Clinical Trials at Replimune
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/16/2026.
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