Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy. Recently, investigators have noticed similar high rates of cancer control in small numbers of patients who receive less intensive treatments using lower doses of radiation, smaller radiation fields with chemotherapy. It is expected that the side effects of treatment with lower doses of radiation would be less. For this reason this study is looking at a different regimen of reducing the intensity of the treatment. The purpose of this study is to compare any good and bad effects of using lower dose smaller fields radiation therapy and chemotherapy with published outcomes. This study will allow the researchers to know whether these different approaches are better, the same, or worse than the usual approach. To be better, the study approach should result in the same survival rate of the usual approach (about 85 out of 100 patients alive and free of cancer at 2 years) but with less long-term side effects.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak komórek kolczystych gardła środkowego (migdałki, nasada języka, podniebienie miękkie, ściany gardła środkowego).
- •Rak widoczny w badaniach lub na obrazach (w głównym miejscu lub w węzłach chłonnych).
- •Rak jest P16-dodatni (potwierdzone badaniem tkanki).
- •Pacjenci w wieku 65 lat i starsi.
- •Dobre wyniki podstawowych badań krwi i narządów (w ciągu 14 dni przed badaniem).
✗ Disqualifies
- •Rak rozsiany po organizmie (z przerzutami).
- •Rak, który powrócił po leczeniu.
- •Choroby współistniejące, które znacznie skracają przewidywaną długość życia (< 1 rok).
- •Choroby autoimmunologiczne.
- •Nieprawidłowo kontrolowany wirus HIV.
Simplified criteria — AI translation
Trial details
- Minimum age
- 65 Years
- Maximum age
- 99 Years
- Last updated (source)
- September 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Baptist MD Anderson Cancer Center
Jacksonville, United States
Trial contact
Regulatory Office
Clinical Trials Office
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/30/2026.
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