RecruitingPhase IIEN original

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase II MyeloMATCH treatment trial compares the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib in treating older and unfit patients with acute myeloid leukemia and FLT3 mutations. Azacitidine is a drug that is absorbed into DNA and leads to the activation of cancer suppressor genes, which are genes that help control cell growth. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Gilteritinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply. This study may help doctors find out if these different approaches are better than the usual approaches. To decide if they are better, the study doctors are looking to see if the study drugs lead to a higher percentage of patients achieving a deeper remission compared to the usual approach.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Pacjent ma 60 lat lub więcej, albo poniżej 60, jeśli lekarz uzna, że standardowe leczenie jest lepsze od intensywnego.
  • Potwierdzona diagnoza ostrej białaczki szpikowej (AML) według klasyfikacji WHO, z wyłączeniem pewnych rzadkich typów.
  • Brak wcześniejszego leczenia białaczki, z wyjątkiem pewnych leków doraźnych.
  • Brak wcześniejszego leczenia lekami zmieniającymi metylację lub lekami działającymi na FLT3.
  • Stwierdzona mutacja FLT3 (ITD lub D835).
  • Pacjentka nie jest w ciąży ani nie karmi piersią.

✗ Disqualifies

  • Pacjentki w wieku rozrodczym muszą mieć negatywny test ciążowy przed rozpoczęciem badania.
  • Pacjentki w wieku rozrodczym i/lub aktywne seksualnie pacjentki nie mogą planować ciąży lub jej doprowadzać podczas badania.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 2, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (223)

University of Alabama at Birmingham Cancer Center

Birmingham, United States

Banner University Medical Center - Tucson

Tucson, United States

University of Arizona Cancer Center-North Campus

Tucson, United States

University of Arkansas for Medical Sciences

Little Rock, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, United States

Kaiser Permanente Dublin

Dublin, United States

Kaiser Permanente-Fremont

Fremont, United States

Kaiser Permanente Fresno Orchard Plaza

Fresno, United States

Kaiser Permanente-Fresno

Fresno, United States

Cedars-Sinai Medical Center

Los Angeles, United States

Kaiser Permanente- Modesto MOB II

Modesto, United States

Kaiser Permanente-Modesto

Modesto, United States

Kaiser Permanente-Oakland

Oakland, United States

Kaiser Permanente-Roseville

Roseville, United States

Kaiser Permanente Downtown Commons

Sacramento, United States

University of California Davis Comprehensive Cancer Center

Sacramento, United States

Kaiser Permanente-South Sacramento

Sacramento, United States

Kaiser Permanente-San Francisco

San Francisco, United States

UCSF Medical Center-Parnassus

San Francisco, United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, United States

Kaiser Permanente San Leandro

San Leandro, United States

Mills Health Center

San Mateo, United States

Kaiser San Rafael-Gallinas

San Rafael, United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, United States

Kaiser Permanente-Santa Rosa

Santa Rosa, United States

Kaiser Permanente-South San Francisco

South San Francisco, United States

Kaiser Permanente-Vallejo

Vallejo, United States

Kaiser Permanente-Walnut Creek

Walnut Creek, United States

Yale University

New Haven, United States

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, United States

UF Health Cancer Institute - Gainesville

Gainesville, United States

Miami Cancer Institute

Miami, United States

Phoebe Putney Memorial Hospital

Albany, United States

Augusta University Medical Center

Augusta, United States

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, United States

Straub Clinic and Hospital

Honolulu, United States

Kaiser Permanente Moanalua Medical Center

Honolulu, United States

Hawaii Cancer Care - Westridge

‘Aiea, United States

Pali Momi Medical Center

‘Aiea, United States

Saint Alphonsus Cancer Care Center-Boise

Boise, United States

Saint Luke's Cancer Institute - Boise

Boise, United States

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, United States

Kootenai Health - Coeur d'Alene

Coeur d'Alene, United States

Saint Luke's Cancer Institute - Fruitland

Fruitland, United States

Saint Luke's Cancer Institute - Meridian

Meridian, United States

Saint Alphonsus Cancer Care Center-Nampa

Nampa, United States

Saint Luke's Cancer Institute - Nampa

Nampa, United States

Kootenai Clinic Cancer Services - Post Falls

Post Falls, United States

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, United States

Northwestern University

Chicago, United States

University of Illinois

Chicago, United States

Carle at The Riverfront

Danville, United States

Cancer Care Specialists of Illinois - Decatur

Decatur, United States

Decatur Memorial Hospital

Decatur, United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, United States

Carle Physician Group-Effingham

Effingham, United States

Crossroads Cancer Center

Effingham, United States

NorthShore University HealthSystem-Evanston Hospital

Evanston, United States

Northwestern Medicine Cancer Center Delnor

Geneva, United States

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, United States

Northwestern Medicine Glenview Outpatient Center

Glenview, United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, United States

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, United States

Edward Hines Jr VA Hospital

Hines, United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, United States

Carle Physician Group-Mattoon/Charleston

Mattoon, United States

Loyola University Medical Center

Maywood, United States

Cancer Care Center of O'Fallon

O'Fallon, United States

Northwestern Medicine Orland Park

Orland Park, United States

Memorial Hospital East

Shiloh, United States

Southern Illinois University School of Medicine

Springfield, United States

Springfield Clinic

Springfield, United States

Springfield Memorial Hospital

Springfield, United States

Carle Cancer Center

Urbana, United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, United States

University of Kansas Clinical Research Center

Fairway, United States

University of Kansas Cancer Center

Kansas City, United States

University of Kansas Hospital-Indian Creek Campus

Overland Park, United States

Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, United States

UofL Health Medical Center Northeast

Louisville, United States

LSU Health Baton Rouge-North Clinic

Baton Rouge, United States

Our Lady of the Lake Physician Group

Baton Rouge, United States

Our Lady of The Lake

Baton Rouge, United States

MaineHealth Cancer Care and IV Therapy - Brunswick

Brunswick, United States

Mid Coast Hospital

Brunswick, United States

MaineHealth Maine Medical Center - Portland

Portland, United States

MaineHealth Maine Medical Center- Scarborough

Scarborough, United States

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, United States

Walter Reed National Military Medical Center

Bethesda, United States

Tufts Medical Center

Boston, United States

Beth Israel Deaconess Medical Center

Boston, United States

Dana-Farber Cancer Institute

Boston, United States

Lahey Clinic

Burlington, United States

Lahey Clinic Peabody

Peabody, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, United States

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, United States

Henry Ford Hospital

Detroit, United States

Cancer Hematology Centers - Flint

Flint, United States

Genesee Hematology Oncology PC

Flint, United States

Genesys Hurley Cancer Institute

Flint, United States

Hurley Medical Center

Flint, United States

Allegiance Health

Jackson, United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, United States

Henry Ford Medical Center-Columbus

Novi, United States

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, United States

Henry Ford West Bloomfield Hospital

West Bloomfield, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, United States

Mercy Hospital

Coon Rapids, United States

Essentia Health - Deer River Clinic

Deer River, United States

Essentia Health Cancer Center

Duluth, United States

Fairview Southdale Hospital

Edina, United States

Essentia Health Hibbing Clinic

Hibbing, United States

Abbott-Northwestern Hospital

Minneapolis, United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, United States

Regions Hospital

Saint Paul, United States

United Hospital

Saint Paul, United States

Essentia Health Sandstone

Sandstone, United States

Essentia Health Virginia Clinic

Virginia, United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, United States

Baptist Cancer Center-Grenada

Grenada, United States

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, United States

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, United States

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, United States

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, United States

Siteman Cancer Center at West County Hospital

Creve Coeur, United States

Washington University School of Medicine

St Louis, United States

Siteman Cancer Center-South County

St Louis, United States

Siteman Cancer Center at Christian Hospital

St Louis, United States

Community Hospital of Anaconda

Anaconda, United States

Billings Clinic Cancer Center

Billings, United States

Bozeman Health Deaconess Hospital

Bozeman, United States

Benefis Sletten Cancer Institute

Great Falls, United States

Logan Health Medical Center

Kalispell, United States

Community Medical Center

Missoula, United States

OptumCare Cancer Care at Charleston

Las Vegas, United States

OptumCare Cancer Care at Fort Apache

Las Vegas, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Memorial Sloan Kettering Basking Ridge

Basking Ridge, United States

Saint Barnabas Medical Center

Livingston, United States

Monmouth Medical Center

Long Branch, United States

Memorial Sloan Kettering Monmouth

Middletown, United States

Memorial Sloan Kettering Bergen

Montvale, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, United States

The Valley Hospital - Luckow Pavilion

Paramus, United States

Valley Health System Ridgewood Campus

Ridgewood, United States

Community Medical Center

Toms River, United States

University of New Mexico Cancer Center

Albuquerque, United States

Roswell Park Cancer Institute

Buffalo, United States

Memorial Sloan Kettering Commack

Commack, United States

Northwell Health/Center for Advanced Medicine

Lake Success, United States

North Shore University Hospital

Manhasset, United States

Memorial Sloan Kettering Cancer Center

New York, United States

University of Rochester

Rochester, United States

Stony Brook University Medical Center

Stony Brook, United States

State University of New York Upstate Medical University

Syracuse, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, United States

Duke University Medical Center

Durham, United States

East Carolina University

Greenville, United States

Wake Forest University Health Sciences

Winston-Salem, United States

Case Western Reserve University

Cleveland, United States

Ohio State University Comprehensive Cancer Center

Columbus, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Providence Newberg Medical Center

Newberg, United States

Saint Alphonsus Cancer Care Center-Ontario

Ontario, United States

Providence Willamette Falls Medical Center

Oregon City, United States

Providence Portland Medical Center

Portland, United States

Providence Saint Vincent Medical Center

Portland, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, United States

Geisinger Medical Center

Danville, United States

Penn State Milton S Hershey Medical Center

Hershey, United States

University of Pennsylvania/Abramson Cancer Center

Philadelphia, United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, United States

Reading Hospital

West Reading, United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, United States

Rhode Island Hospital

Providence, United States

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, United States

Medical University of South Carolina

Charleston, United States

Prisma Health Cancer Institute - Easley

Easley, United States

Prisma Health Cancer Institute - Butternut

Greenville, United States

Prisma Health Cancer Institute - Faris

Greenville, United States

Prisma Health Cancer Institute - Eastside

Greenville, United States

Prisma Health Cancer Institute - Greer

Greer, United States

Prisma Health Cancer Institute - Seneca

Seneca, United States

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, United States

University of Tennessee - Knoxville

Knoxville, United States

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, United States

Ben Taub General Hospital

Houston, United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, United States

George E Wahlen Department of Veterans Affairs Medical Center

Salt Lake City, United States

University of Vermont Medical Center

Burlington, United States

University of Vermont and State Agricultural College

Burlington, United States

University of Virginia Cancer Center

Charlottesville, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

Swedish Cancer Institute-Edmonds

Edmonds, United States

Swedish Cancer Institute-Issaquah

Issaquah, United States

Fred Hutchinson Cancer Center

Seattle, United States

Swedish Medical Center-First Hill

Seattle, United States

University of Washington Medical Center - Montlake

Seattle, United States

ThedaCare Regional Cancer Center

Appleton, United States

Duluth Clinic Ashland

Ashland, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, United States

Gundersen Lutheran Medical Center

La Crosse, United States

William S Middleton VA Medical Center

Madison, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Medical College of Wisconsin

Milwaukee, United States

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, United States

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, United States

Marshfield Medical Center - Weston

Weston, United States

Centro Comprensivo de Cancer de UPR

San Juan, Puerto Rico

San Juan City Hospital

San Juan, Puerto Rico

Trial contact

Site Public Contact

Razan Mohty

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sharad Khurana

PRINCIPAL_INVESTIGATOR

Site Public Contact

Ankur Varma

PRINCIPAL_INVESTIGATOR

Ari D. Baron

PRINCIPAL_INVESTIGATOR

Site Public Contact

Faisal N. Cheema

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Noah M. Merin

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Brian A. Jonas

PRINCIPAL_INVESTIGATOR

Site Public Contact

Timothy Ferng

PRINCIPAL_INVESTIGATOR

Jan P. Bewersdorf

PRINCIPAL_INVESTIGATOR

Site Public Contact

Alexander Pine

PRINCIPAL_INVESTIGATOR

Site Public Contact

Dina G. Khalaf

PRINCIPAL_INVESTIGATOR

Site Public Contact

Firas El Chaer

PRINCIPAL_INVESTIGATOR

Vamsi Kota

PRINCIPAL_INVESTIGATOR

Craig S. Boddy

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Tareq Al baghdadi

PRINCIPAL_INVESTIGATOR

Alison K. Conlin

PRINCIPAL_INVESTIGATOR

John M. Schallenkamp

PRINCIPAL_INVESTIGATOR

Yasmin Abaza

PRINCIPAL_INVESTIGATOR

Site Public Contact

Noah Birch

PRINCIPAL_INVESTIGATOR

Suparna Mantha

PRINCIPAL_INVESTIGATOR

Bryan A. Faller

PRINCIPAL_INVESTIGATOR

Site Public Contact

Robert M. Eisner

PRINCIPAL_INVESTIGATOR

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Site Public Contact

Stephanie B. Tsai

PRINCIPAL_INVESTIGATOR

Ramzi Abboud

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Rita Assi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Prajwal Dhakal

PRINCIPAL_INVESTIGATOR

Jesus Gonzalez Lugo

PRINCIPAL_INVESTIGATOR

Site Public Contact

Brandon R. Weckbaugh

PRINCIPAL_INVESTIGATOR

Site Public Contact

Ayman Qasrawi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Mohamed M. Hegazi

PRINCIPAL_INVESTIGATOR

Harry G. Sequeira Gross

PRINCIPAL_INVESTIGATOR

Site Public Contact

Pamela Egan

PRINCIPAL_INVESTIGATOR

Site Public Contact

Ryan Jones

PRINCIPAL_INVESTIGATOR

Andreas K. Klein

PRINCIPAL_INVESTIGATOR

Site Public Contact

Malgorzata McMasters

PRINCIPAL_INVESTIGATOR

Site Public Contact

Eric S. Winer

PRINCIPAL_INVESTIGATOR

Hossein Sadrzadeh

PRINCIPAL_INVESTIGATOR

Christopher A. Willner

PRINCIPAL_INVESTIGATOR

Site Public Contact

David M. King

PRINCIPAL_INVESTIGATOR

Bret E. Friday

PRINCIPAL_INVESTIGATOR

Site Public Contact

Muhammad Raza

PRINCIPAL_INVESTIGATOR

John A. Ellerton

PRINCIPAL_INVESTIGATOR

Raphael A. Lizcano

PRINCIPAL_INVESTIGATOR

Site Public Contact

Aaron D. Goldberg

PRINCIPAL_INVESTIGATOR

Neil D. Palmisiano

PRINCIPAL_INVESTIGATOR

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Jason Suh

PRINCIPAL_INVESTIGATOR

Charles Foucar

PRINCIPAL_INVESTIGATOR

Eunice S. Wang

PRINCIPAL_INVESTIGATOR

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Erin Jou

PRINCIPAL_INVESTIGATOR

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Paul M. Barr

PRINCIPAL_INVESTIGATOR

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Suhu Liu

PRINCIPAL_INVESTIGATOR

Site Public Contact

Teresa C. Gentile

PRINCIPAL_INVESTIGATOR

Joshua F. Zeidner

PRINCIPAL_INVESTIGATOR

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Michael R. Grunwald

PRINCIPAL_INVESTIGATOR

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Harry P. Erba

PRINCIPAL_INVESTIGATOR

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Darla K. Liles

PRINCIPAL_INVESTIGATOR

Site Public Contact

Timothy S. Pardee

PRINCIPAL_INVESTIGATOR

Ali W. Bseiso

PRINCIPAL_INVESTIGATOR

Jayanshu Jain

PRINCIPAL_INVESTIGATOR

Mohamad Khawandanah

PRINCIPAL_INVESTIGATOR

Joseph J. Vadakara

PRINCIPAL_INVESTIGATOR

Site Public Contact

Joseph Cioccio

PRINCIPAL_INVESTIGATOR

Alexander E. Perl

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Annie P. Im

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Terrence P. Cescon

PRINCIPAL_INVESTIGATOR

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John L. Reagan

PRINCIPAL_INVESTIGATOR

Suzanne R. Fanning

PRINCIPAL_INVESTIGATOR

Praneeth Baratam

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Clark Cutrer

PRINCIPAL_INVESTIGATOR

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Tareq Abuasab

PRINCIPAL_INVESTIGATOR

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Paul J. Shami

PRINCIPAL_INVESTIGATOR

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Tsewang Tashi

PRINCIPAL_INVESTIGATOR

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Diego A. Adrianzen Herrera

PRINCIPAL_INVESTIGATOR

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Daniel R. Reed

PRINCIPAL_INVESTIGATOR

Keri R. Maher

PRINCIPAL_INVESTIGATOR

Site Public Contact

Jacob S. Appelbaum

PRINCIPAL_INVESTIGATOR

Yazhini Vallatharasu

PRINCIPAL_INVESTIGATOR

Brian L. Burnette

PRINCIPAL_INVESTIGATOR

Kurt Oettel

PRINCIPAL_INVESTIGATOR

Site Public Contact

Christopher D. Fletcher

PRINCIPAL_INVESTIGATOR

Kieran D. Sahasrabudhe

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sameem M. Abedin

PRINCIPAL_INVESTIGATOR

Adedayo A. Onitilo

PRINCIPAL_INVESTIGATOR

Site Public Contact

Luis J. Santos Reyes

PRINCIPAL_INVESTIGATOR

Site Public Contact

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.