Personalized Vaccine Immunotherapy in Combination With Checkpoint Inhibitor for Treatment of Triple Negative Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial tests the safety, side effects, and best dose of a personalized vaccine (tumor membrane vesicle or TMV vaccine) by itself and in combination with checkpoint inhibitor (pembrolizumab or ipilimumab) in treating patients with triple negative breast cancer. This vaccine is made by taking a piece of patient's triple negative breast cancer to design a vaccine to stimulate the immune system's memory. Patients are treated with the personalized vaccine immunotherapy with or without monoclonal antibodies, such as pembrolizumab and ipilimumab. This approach may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving personalized TMV vaccine with pembrolizumab or ipilimumab may help the immune system attack cancer better and reduce the risk of this breast cancer coming back or growing.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Dobry stan ogólny (zdolność do codziennych czynności)
- •Wystarczająca liczba białych krwinek (> 1500/mcL)
- •Wystarczająca liczba limfocytów (>= 600 cells/µl)
- •Wystarczająca liczba płytek krwi (> 100 000/mm)
- •Wystarczająca ilość hemoglobiny (> 9,0 g/dL)
- •Prawidłowa funkcja nerek (kreatynina =< 1,5 x norma)
- •Rak piersi potrójowie ujemny (bez receptorów hormonalnych i HER2) z przerzutami lub zaawansowany nieopers
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- January 26, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (4)
Grady Health System
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Trial contact
Keerthi Gogineni, MD, MSHP
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.