Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent. Subjects will be provided 21 days of standardized High-fiber/low-fat meals and complete a food diary up until lunch on the day prior to surgery. Blood samples will be collected at baseline and on the day of surgery. Stool samples will be collected throughout the dietary intervention period at specific timepoints, on the day of surgery, and 30 days post-surgery. Tissue from the tumor resection will be isolated for organoid cultures. Subjects will be followed per standard of care for up to 5 years or disease recurrence, whichever comes first. Subject may be treated for their cancer prior to surgery and/or during the follow-up period.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza raka jelita grubego
- •Zaplanowana operacja usunięcia guza w University of Chicago Medicine co najmniej 21 dni od wyrażenia zgody
- •Wiek 18 lat i więcej
- •Może mieć przerzuty, jeśli pierwotny guz będzie usuwany
- •Wcześniejsza chemioterapia lub radioterapia przed operacją jest dozwolona
- •Zdolność do zrozumienia i podpisania zgody na udział w badaniu
✗ Disqualifies
- •Poprzednia stomia jelitowa lub planowana stomia podczas operacji
- •Antybiotyki przyjmowane w ciągu 60 dni przed dietą
- •Prebiotyki lub probiotyki w ciągu 60 dni przed dietą
- •Inne jednoczesne nowotwory
- •Alergia na leki używane przy operacji (neomycyna, metronidazol, cefazolin)
- •Ciąża
- •Niezapalnie choroby jelit w historii
- •Ciężkie alergie pokarmowe uniemożliwiające tolerancję diety
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
University of Chicago
Chicago, United States
Trial contact
Benjamin Shogan, MD
Teresa Barry
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/22/2026.
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