Evaluation of Immune Responses and Outcomes in Patients With Hepatocellular Carcinoma Undergoing Radiotherapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Radiation therapy is a highly effective modality for managing localized solid tumors and has become a fundamental component of treating unresectable hepatocellular carcinoma. Our previous preclinical investigation revealed that radiotherapy can initiate immunogenic cell death and facilitate the cross-presentation of tumor antigens by antigen-presenting cells, thereby augmenting systemic anti-tumor T cell responses in murine tumor models. However, this immune response subsequent to irradiation has not been comprehensively evaluated in clinical trials involving hepatocellular carcinoma patients. Given that radiotherapy represents a standard therapeutic approach for unresectable hepatocellular carcinoma, our ongoing phase II non-randomized trial aims to prospectively assess immunological responses and dose-volumetric parameters, while identifying predictors of clinical outcomes in patients undergoing definitive radiotherapy for hepatocellular carcinoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent musi mieć potwierdzonego raka wątroby.
- •Pacjent musi mieć ukończone 18 lat.
- •Stan ogólny pacjenta pozwala na leczenie (oceniany w skali ECOG 0-2).
- •Wyniki badań wątroby (Child-Pugh 5-9) mieszczą się w określonych normach.
- •Zbadano obecność wirusa zapalenia wątroby typu B (HBV).
- •Zbadano obecność wirusa zapalenia wątroby typu C (HCV).
- •Pacjent jest w stanie zrozumieć i zgodzić się na udział w badaniu.
✗ Disqualifies
- •Rak wątroby z przerzutami do innych części ciała, których nie można objąć radioterapią.
- •Ciąża lub planowanie ciąży, lub brak zgody na stosowanie skutecznej antykoncepcji.
- •Nie można objąć radioterapią wszystkich miejsc, gdzie jest obecny nowotwór.
- •Pacjent ma zdiagnozowane zakażenie wirusem HIV.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Chang Gung Memorial Hospital at Linkou
Taoyuan City, Taiwan
Trial contact
Rodney Cheng-En Hsieh, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/2/2026.
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