Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positive, HER2-negative (defined as IHC 0, 1+, 2+/ ISH non-amplified) advanced breast cancer
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dorosłe kobiety (przed, w trakcie lub po menopauzie) oraz dorośli mężczyźni
- •Potwierdzony nowotwór piersi dodatni na receptor hormonalny i ujemny na HER2
- •Zaawansowany nowotwór piersi, który nie może być wyleczony operacyjnie lub rozprzestrzeniło się na inne części ciała
- •Dobry ogólny stan zdrowia (wynik 0 lub 1 w skali ECOG bez pogorszenia w ostatnich 2 tygodniach)
- •Pobrany materiał tkankowy z guza
- •Potwierdzona mutacja genetyczna BRCA1, BRCA2 lub PALB2
- •Prawidłowe funkcjonowanie narządów i szpiku kostnego
✗ Disqualifies
- •Historia zespołu mielodysplastycznego lub białaczki
- •Склonność do krwawień
- •Historia poważnego i długotrwałego zmniejszenia liczby komórek krwi
- •Poważne choroby zakaźne lub inne niekontrolowane choroby
- •Opory niezleczone nudności i wymioty, choroby przewodu pokarmowego lub wcześniejsza duża operacja jelit
- •Historia innego nowotworu złośliwego
- •Efekty uboczne po poprzedniej chemioterapii (stopień 2 lub wyższy, z wyjątkiem wypadania włosów)
- •Uciśnięcie rdzenia kręgowego, przerzuty do mózgu lub rozprzestrzenienie się raka na opony mózgowe
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (301)
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Gilbert, United States
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Fountain Valley, United States
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Glendale, United States
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Los Angeles, United States
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Newport Beach, United States
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Aurora, United States
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Grand Junction, United States
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Hollywood, United States
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Jacksonville, United States
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Orlando, United States
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Chicago, United States
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Evanston, United States
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Park Ridge, United States
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Urbana, United States
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Winfield, United States
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Indianapolis, United States
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Louisville, United States
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Baltimore, United States
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Silver Spring, United States
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Silver Spring, United States
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Boston, United States
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Dearborn, United States
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Detroit, United States
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Royal Oak, United States
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Royal Oak, United States
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Rochester, United States
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Saint Joseph, United States
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Springfield, United States
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St Louis, United States
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Camden, United States
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New Brunswick, United States
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Brooklyn, United States
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Mineola, United States
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New Hyde Park, United States
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New York, United States
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New York, United States
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New York, United States
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Shirley, United States
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Stony Brook, United States
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The Bronx, United States
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Westbury, United States
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Hershey, United States
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Philadelphia, United States
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Pittsburgh, United States
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Pittsburgh, United States
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West Columbia, United States
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Chattanooga, United States
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Nashville, United States
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Houston, United States
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Houston, United States
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Houston, United States
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San Antonio, United States
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Norfolk, United States
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Tacoma, United States
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Morgantown, United States
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Milwaukee, United States
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Ciudad Autónoma Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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Rosario, Argentina
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Salta, Argentina
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San Miguel de Tucumán, Argentina
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Darlinghurst, Australia
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Darlinghurst, Australia
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Malvern, Australia
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Melbourne, Australia
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Vienna, Austria
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Cachoeira de Itapemirim, Brazil
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Curitiba, Brazil
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Fortaleza, Brazil
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Goiânia, Brazil
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Jaú, Brazil
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Porto Alegre, Brazil
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Ribeirão Preto, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Plovdiv, Bulgaria
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Sofia, Bulgaria
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Stara Zagora, Bulgaria
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Vratsa, Bulgaria
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Toronto, Canada
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Greenfield Park, Canada
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Montreal, Canada
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Montreal, Canada
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Montreal, Canada
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Saskatoon, Canada
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Toronto, Canada
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Providencia, Chile
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Recoleta, Chile
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Santiago, Chile
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Talca, Chile
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Viña del Mar, Chile
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Beijing, China
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Bengbu, China
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Changchun, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Foshan, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Hohhot, China
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Jining, China
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Kunming, China
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Liuzhou, China
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Luoyang, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Shandong, China
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Shanghai, China
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Shanghai, China
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Shenyang, China
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Shijiazhuang, China
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Tianjin, China
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Weifang, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Xiamen, China
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Xiangyang, China
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Xinxiang, China
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Zhengzhou, China
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Brno, Czechia
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Hořovice, Czechia
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Hradec Králové, Czechia
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Olomouc, Czechia
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Prague, Czechia
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Prague, Czechia
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Angers, France
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Besançon, France
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Lille, France
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Lyon, France
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Marseille, France
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Paris, France
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Rouen, France
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Saint-Herblain, France
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Toulouse, France
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Villejuif, France
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Aachen, Germany
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Augsburg, Germany
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Berlin, Germany
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Cologne, Germany
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Dessau, Germany
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Düsseldorf, Germany
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Erlangen, Germany
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Göttingen, Germany
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Hamburg, Germany
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Hanover, Germany
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Heidelberg, Germany
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Kiel, Germany
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Leipzig, Germany
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Ludwigsburg, Germany
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München, Germany
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Münster, Germany
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Hong Kong, Hong Kong
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Hong Kong, Hong Kong
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Debrecen, Hungary
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Miskolc, Hungary
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Zalaegerszeg, Hungary
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Delhi, India
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Kolkata, India
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Lucknow, India
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Mumbai, India
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Mumbai, India
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Mysuru, India
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Nagpur, India
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Nashik, India
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New Delhi, India
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Surat, India
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Thiruvananthapuram, India
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Jerusalem, Israel
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Jerusalem, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Bergamo, Italy
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Bologna, Italy
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Milan, Italy
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Milan, Italy
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Modena, Italy
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Naples, Italy
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Padova, Italy
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Reggio Emilia, Italy
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Rome, Italy
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Rozzano, Italy
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Chiba, Japan
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Hidaka-shi, Japan
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Hirakata-shi, Japan
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Isehara-shi, Japan
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Kagoshima, Japan
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Kashiwa, Japan
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Kōtoku, Japan
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Kumamoto, Japan
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Kyoto, Japan
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Matsuyama, Japan
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Nagoya, Japan
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Nagoya, Japan
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Nagoya, Japan
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Osaka, Japan
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Ota-shi, Japan
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Sapporo, Japan
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Sendai, Japan
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Shinagawa-ku, Japan
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Suita-shi, Japan
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Sunto-gun, Japan
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Takasaki-shi, Japan
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Tsu, Japan
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Yokohama, Japan
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Bandar Puncak Alam, Malaysia
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Johor Bahru, Malaysia
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Kuala Lumpur, Malaysia
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Kuala Selangor, Malaysia
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Malacca, Malaysia
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Bellavista, Peru
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Jesus Maria, Lima, Peru
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Lima, Peru
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Lima, Peru
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Biała Podlaska, Poland
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Koszalin, Poland
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Lodz, Poland
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Lublin, Poland
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Poznan, Poland
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Poznan, Poland
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Radom, Poland
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Warsaw, Poland
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Coimbra, Portugal
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Lisbon, Portugal
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Lisbon, Portugal
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Matosinhos Municipality, Portugal
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Porto, Portugal
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Vila Real, Portugal
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San Juan, Puerto Rico
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Daegu, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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A Coruña, Spain
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Barcelona, Spain
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Cáceres, Spain
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Granada, Spain
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L'Hospitalet de Llobregat, Spain
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Madrid, Spain
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Madrid, Spain
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Málaga, Spain
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Pamplona, Spain
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Seville, Spain
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Valencia, Spain
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Zaragoza, Spain
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New Taipei City, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Dusit, Thailand
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Hat Yai, Thailand
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Muang, Thailand
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Ratchathewi, Thailand
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Ratchathewi, Thailand
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Adapazarı, Turkey (Türkiye)
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Altındağ-Ankara, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Çankaya, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Kayseri, Turkey (Türkiye)
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Cambridge, United Kingdom
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Guildford, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Oxford, United Kingdom
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Swansea, United Kingdom
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Taunton, United Kingdom
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Truro, United Kingdom
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.