A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
PEGASUS aims to test acceptability and feasibility of studying phenoconversion (the change in metabolism phenotype) using probe medications in a paediatric oncology patient population. The study will be conducted in patients (6-25 years of age) with Hodgkin lymphoma or non-Hodgkin lymphoma as exemplar cohort, but with the understanding that cancer-directed and supportive care medicines of the CYP3A4, CYP2C19, and CYP2D6 metabolic pathways are commonly utilised for the treatment of many paediatric, adolescent, young adult, and adult cancers. The study involves administration of the probe medication at timepoints which align with pre-determined hospital visits for the treatment of lymphoma and subsequent blood draws to measure the metabolism of the probe medications. The acceptability and feasibility of this study will inform future studies in phenoconversion within the paediatric cancer population to direct more personalised precision medicine.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 6-25 lat
- •Nowo rozpoznany chłoniak Hodgkina lub inny chłoniak nieziarniczy
- •Zdolność do połykania leku lub przyjmowania go przez sondę
- •Możliwość udzielenia pisemnej zgody przez pacjenta lub opiekuna
✗ Disqualifies
- •Alergia na którąkolwiek z substancji badawczych (omeprazol lub dekstrometorfan)
- •Poważne problemy z wątrobą, nerkami lub przewodem pokarmowym
- •Poprzednie leczenie nowotworu (nie pierwsza diagnoza)
- •Niestabilny stan kliniczny wymagający opieki na oddziale intensywnym
- •Konieczność natychmiastowego rozpoczęcia leczenia poza godzinami pracy, gdy nie można uzyskać zgody
Simplified criteria — AI translation
Trial details
- Minimum age
- 6 Years
- Maximum age
- 25 Years
- Last updated (source)
- August 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Peter MacCallum Cancer Centre
Melbourne, Australia
Trial contact
Rachel Conyers, MBBS (Hons)
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/28/2026.
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