A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, amivantamab in addition to paclitaxel and amivantamab in addition to pembrolizumab and carboplatin in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel. The safety and preliminary efficacy of amivantamab in addition to pembrolizumab will also be determined in perioperative (before and after surgery) setting in participants with resectable locally advanced head and neck squamous cell carcinoma (HNSCC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak głowy i szyi, który powrócił lub się rozprzestrzenił i nie można go wyleczyć miejscowo.
- •Rak głowy i szyi we wczesnym stadium zaawansowania, który można wyleczyć operacyjnie.
- •Nowotwór zlokalizowany w określonych miejscach, np. gardle środkowym, jamie ustnej, krtani.
- •Badanie uwzględnia różne wcześniejsze sposoby leczenia.
- •Pacjenci z rakiem gardła środkowego muszą mieć negatywny wynik testu na obecność białka p16.
- •Pacjenci mogą mieć wyniki badania PD-L1, jeśli są dostępne.
- •Pacjenci z określonymi typami nowotworów HPV-dodatnich mogą być zakwalifikowani.
- •Choroba w stadium III lub IVa, którą można usunąć operacyjnie.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (56)
University of California at San Diego Moores Cancer Center
La Jolla, United States
University of Colorado Denver Anschultz Medical Campus
Aurora, United States
Yale Cancer Center
New Haven, United States
The University of Chicago Medical Center (UCMC)
Chicago, United States
University of Maryland School of Medicine
Baltimore, United States
Dana Farber Cancer Institute
Boston, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
Karmanos Cancer Institute
Detroit, United States
Washington University School Of Medicine
St Louis, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
University of North Carolina at Chapel Hill
Chapel Hill, United States
Cleveland Clinic
Cleveland, United States
University of Utah Huntsman Cancer Institute
Salt Lake City, United States
University of Virginia
Charlottesville, United States
Virginia Cancer Specialists
Fairfax, United States
Beijing Cancer Hospital of Peking University
Beijing, China
West China School of Medicine/West China Hospital, Sichuan University
Cheng Du Shi, China
Linyi Cancer Hospital
Linyi, China
Fudan Cancer Hospital
Shanghai, China
Shanghai East Hospital
Shanghai, China
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
Institut Sainte Catherine
Avignon, France
Centre Oscar Lambret
Lille, France
CHU Nantes
Nantes, France
Institut Curie
Paris, France
Gustave Roussy
Villejuif, France
Universitaetsklinikum Essen
Essen, Germany
Universitaetsklinikum Leipzig
Leipzig, Germany
Klinikum der Landeshauptstadt Stuttgart
Stuttgart, Germany
Aichi Cancer Center
Nagoya, Japan
Tokyo Medical University Hospital
Tokyo, Japan
Pantai Hospital Kuala Lumpur
Kuala Lumpur, Malaysia
University Malaya Medical Centre
Kuala Lumpur, Malaysia
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Centrum Onkologii Instytut im M Sklodowskiej Curie Oddzial w Gliwicach
Gliwice, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
Warsaw, Poland
Seoul National University Hospital
Seoul, South Korea
Severance Hospital Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hosp Univ Vall D Hebron
Barcelona, Spain
Inst. Cat. Doncologia-H Duran I Reynals
Barcelona, Spain
Hosp. Univ. Ramon Y Cajal
Madrid, Spain
Hosp. Univ. 12 de Octubre
Madrid, Spain
Changhua Christian Hospital
Changhua, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan
Addenbrooke's Hospital
Cambridge, United Kingdom
The Royal Surrey County Hospital NHS Foundation Trust
Guildford, United Kingdom
Royal Marsden Hospital (Sutton)
London, United Kingdom
Royal Marsden Hospital
London, United Kingdom
Imperial College London and Imperial College Healthcare NHS Trust
London, United Kingdom
University College London Hospitals
London, United Kingdom
The Christie Nhs Foundation Trust
Manchester, United Kingdom
Trial contact
Study Contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.
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